Children and adolescents with follicular lymphoma have an
excellent prognosis with either limited chemotherapy or with a

J 2013

Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection

ATTARBASCHI, Andishe; Auke BEISHUIZEN; Georg MANN; Angelo ROSOLEN; Tetsuya MORI et. al.

Základní údaje

Originální název

Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection

Autoři

ATTARBASCHI, Andishe (40 Rakousko); Auke BEISHUIZEN (528 Nizozemské království); Georg MANN (40 Rakousko); Angelo ROSOLEN (380 Itálie); Tetsuya MORI (392 Japonsko); Anne UYTTEBROECK (56 Belgie); Felix NIGGLI (756 Švýcarsko); Monika CSOKA (348 Maďarsko); Zdenka KŘENOVÁ (203 Česká republika, garant, domácí); Karin MELLGREN (752 Švédsko); Edita KABICKOVA (203 Česká republika); Alan KS CHIANG (344 Hongkong); Alfred REITER (276 Německo); Denise WILLIAMS (826 Velká Británie a Severní Irsko) a Birgit BURKHARDT (276 Německo)

Vydání

Annals of hematology, Berlin, Springer Verlag, 2013, 0939-5555

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.396

Kód RIV

RIV/00216224:14110/13:00068306

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1007/s00277-013-1785-2

UT WoS

000325357600012

Klíčová slova anglicky

"Watch and wait"; Complete resection; Follicular lymphoma; Outcome

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 12. 2013 15:34, Soňa Böhmová

Anotace

V originále

Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % >/- 10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 +/- 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.

Citovat

ATTARBASCHI, Andishe; Auke BEISHUIZEN; Georg MANN; Angelo ROSOLEN; Tetsuya MORI; Anne UYTTEBROECK; Felix NIGGLI; Monika CSOKA; Zdenka KŘENOVÁ; Karin MELLGREN; Edita KABICKOVA; Alan KS CHIANG; Alfred REITER; Denise WILLIAMS a Birgit BURKHARDT. Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection. Annals of hematology. Berlin: Springer Verlag, 2013, roč. 92, č. 11, s. 1537-1541. ISSN 0939-5555. Dostupné z: https://doi.org/10.1007/s00277-013-1785-2.

@article{1106994,
   author = {Attarbaschi, Andishe and Beishuizen, Auke and Mann, Georg and Rosolen, Angelo and Mori, Tetsuya and Uyttebroeck, Anne and Niggli, Felix and Csoka, Monika and Křenová, Zdenka and Mellgren, Karin and Kabickova, Edita and Chiang, Alan KS and Reiter, Alfred and Williams, Denise and Burkhardt, Birgit},
   article_location = {Berlin},
   article_number = {11},
   doi = {https://doi.org/10.1007/s00277-013-1785-2},
   keywords = {"Watch and wait"; Complete resection; Follicular lymphoma; Outcome},
   language = {eng},
   issn = {0939-5555},
   journal = {Annals of hematology},
   title = {Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection},
   volume = {92},
   year = {2013}
}

TY  - JOUR
ID  - 1106994
AU  - Attarbaschi, Andishe - Beishuizen, Auke - Mann, Georg - Rosolen, Angelo - Mori, Tetsuya - Uyttebroeck, Anne - Niggli, Felix - Csoka, Monika - Křenová, Zdenka - Mellgren, Karin - Kabickova, Edita - Chiang, Alan KS - Reiter, Alfred - Williams, Denise - Burkhardt, Birgit
PY  - 2013
TI  - Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection
JF  - Annals of hematology
VL  - 92
IS  - 11
SP  - 1537-1541
EP  - 1537-1541
PB  - Springer Verlag
SN  - 09395555
KW  - "Watch and wait"
KW  - Complete resection
KW  - Follicular lymphoma
KW  - Outcome
N2  - Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % >/- 10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 +/- 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.
ER  -

ATTARBASCHI, Andishe; Auke BEISHUIZEN; Georg MANN; Angelo ROSOLEN; Tetsuya MORI; Anne UYTTEBROECK; Felix NIGGLI; Monika CSOKA; Zdenka KŘENOVÁ; Karin MELLGREN; Edita KABICKOVA; Alan KS CHIANG; Alfred REITER; Denise WILLIAMS a Birgit BURKHARDT. Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a ''watch and wait'' strategy after complete resection. \textit{Annals of hematology}. Berlin: Springer Verlag, 2013, roč.~92, č.~11, s.~1537-1541. ISSN~0939-5555. Dostupné z: https://doi.org/10.1007/s00277-013-1785-2.

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