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@misc{1116111,
author = {Potáček, Milan and Buchlovič, Marian and Kříž, Zdeněk and Hofr, Ctirad},
keywords = {nitrone; PAH substitution; molecular modeling; activity testing in vitro;},
language = {eng},
title = {Synthesis, activity and interaction of nitrone functionalized PAH derivatives},
year = {2013}
}
TY - SLIDE
ID - 1116111
AU - Potáček, Milan - Buchlovič, Marian - Kříž, Zdeněk - Hofr, Ctirad
PY - 2013
TI - Synthesis, activity and interaction of nitrone functionalized PAH derivatives
KW - nitrone
KW - PAH substitution
KW - molecular modeling
KW - activity testing in vitro;
N2 - Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3.
ER -
POTÁČEK, Milan, Marian BUCHLOVIČ, Zdeněk KŘÍŽ a Ctirad HOFR. \textit{Synthesis, activity and interaction of nitrone functionalized PAH derivatives}. 2013.
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