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@article{1118656,
author = {Loja, Tomáš and Stehlikova, Olga and Palko, Lukas and Vrba, Kamil and Rampl, Ivan and Klabusay, Martin},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.3109/15368378.2013.800104},
keywords = {Cancer cell lines; cell viability; pulsed electromagnetic field (PEMF); pulsed vector magnetic potential (PVMP) field},
language = {eng},
issn = {1536-8378},
journal = {Electromagnetic Biology and Medicine},
title = {Influence of pulsed electromagnetic and pulsed vector magnetic potential field on the growth of tumor cells},
volume = {33},
year = {2014}
}
TY - JOUR
ID - 1118656
AU - Loja, Tomáš - Stehlikova, Olga - Palko, Lukas - Vrba, Kamil - Rampl, Ivan - Klabusay, Martin
PY - 2014
TI - Influence of pulsed electromagnetic and pulsed vector magnetic potential field on the growth of tumor cells
JF - Electromagnetic Biology and Medicine
VL - 33
IS - 3
SP - 190-197
EP - 190-197
PB - INFORMA HEALTH CARE
SN - 15368378
KW - Cancer cell lines
KW - cell viability
KW - pulsed electromagnetic field (PEMF)
KW - pulsed vector magnetic potential (PVMP) field
N2 - Aims and Background: Tumor diseases cause 20% of deaths in Europe and they are the second most common cause of death and morbidity after cardiovascular diseases. Thus, tumor cells are target of many therapeutic strategies and tumor research is focused on searching more efficient and specific drugs as well as new therapeutic approaches. One of the areas of tumor research is an issue of external fields. In our work, we tested influence of a pulsed electromagnetic field (PEMF) and a hypothetic field of the pulsed vector magnetic potential (PVMP) on the growth of tumor cells; and further the possible growth inhibition effect of the PVMP. Methods: Both unipolar and bipolar PEMF fields of 5mT and PVMP fields of 0mT at frequencies of 15 Hz, 125 Hz and 625 Hz were tested on cancer cell lines derived from various types of tumors: CEM/C2 (acute lymphoblastic leukemia), SU-DHL-4 (B-cell lymphoma), COLO-320DM (colorectal adenocarcinoma), MDA-BM-468 (breast adenocarcinoma), and ZR-75-1 (ductal carcinoma). Cell morphology was observed, proliferation activity using WST assay was measured and simultaneous proportion of live, early apoptotic and dead cells was detected using flow cytometry. Results: A PEMF of 125 Hz and 625 Hz for 24 h-48 h increased proliferation activity in the 2 types of cancer cell lines used, i.e. COLO-320DM and ZR-75-1. In contrast, any of employed methods did not confirm a significant inhibitory effect of hypothetic PVMP field on tumor cells.
ER -
LOJA, Tomáš, Olga STEHLIKOVA, Lukas PALKO, Kamil VRBA, Ivan RAMPL a Martin KLABUSAY. Influence of pulsed electromagnetic and pulsed vector magnetic potential field on the growth of tumor cells. \textit{Electromagnetic Biology and Medicine}. NEW YORK: INFORMA HEALTH CARE, 2014, roč.~33, č.~3, s.~190-197. ISSN~1536-8378. Dostupné z: https://dx.doi.org/10.3109/15368378.2013.800104.
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