Role of platelet chemokines, PF-4 and CTAP-III, in cancer
biology

J 2013

Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

PILÁTOVÁ, Kateřina; Kristína GREPLOVÁ; Regina DEMLOVÁ; Beatrix BENCSIKOVÁ; Giannoula Lakka KLEMENT et al.

Základní údaje

Originální název

Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

Autoři

PILÁTOVÁ, Kateřina; Kristína GREPLOVÁ; Regina DEMLOVÁ; Beatrix BENCSIKOVÁ; Giannoula Lakka KLEMENT a Lenka ZDRAŽILOVÁ DUBSKÁ

Vydání

Journal of Hematology & Oncology, LONDON, BIOMED CENTRAL LTD, 2013, 1756-8722

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.933

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00069034

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1186/1756-8722-6-42

UT WoS

000321009900001

Klíčová slova anglicky

Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 4. 2014 10:13, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.

Citovat

PILÁTOVÁ, Kateřina; Kristína GREPLOVÁ; Regina DEMLOVÁ; Beatrix BENCSIKOVÁ; Giannoula Lakka KLEMENT a Lenka ZDRAŽILOVÁ DUBSKÁ. Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology. Journal of Hematology & Oncology. LONDON: BIOMED CENTRAL LTD, 2013, roč. 6, č. 42, s. 1-8. ISSN 1756-8722. Dostupné z: https://doi.org/10.1186/1756-8722-6-42.

@article{1119471,
   author = {Pilátová, Kateřina and Greplová, Kristína and Demlová, Regina and Bencsiková, Beatrix and Klement, Giannoula Lakka and Zdražilová Dubská, Lenka},
   article_location = {LONDON},
   article_number = {42},
   doi = {https://doi.org/10.1186/1756-8722-6-42},
   keywords = {Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation},
   language = {eng},
   issn = {1756-8722},
   journal = {Journal of Hematology & Oncology},
   title = {Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology},
   url = {http://www.jhoonline.org/content/6/1/42},
   volume = {6},
   year = {2013}
}

TY  - JOUR
ID  - 1119471
AU  - Pilátová, Kateřina - Greplová, Kristína - Demlová, Regina - Bencsiková, Beatrix - Klement, Giannoula Lakka - Zdražilová Dubská, Lenka
PY  - 2013
TI  - Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
JF  - Journal of Hematology & Oncology
VL  - 6
IS  - 42
SP  - 1-8
EP  - 1-8
PB  - BIOMED CENTRAL LTD
SN  - 17568722
KW  - Platelet
KW  - PF-4
KW  - CTAP-III
KW  - Cancer
KW  - Angiogenesis
KW  - IL-8
KW  - Inflammation
UR  - http://www.jhoonline.org/content/6/1/42
N2  - With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
ER  -

PILÁTOVÁ, Kateřina; Kristína GREPLOVÁ; Regina DEMLOVÁ; Beatrix BENCSIKOVÁ; Giannoula Lakka KLEMENT a Lenka ZDRAŽILOVÁ DUBSKÁ. Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology. \textit{Journal of Hematology \&{} Oncology}. LONDON: BIOMED CENTRAL LTD, 2013, roč.~6, č.~42, s.~1-8. ISSN~1756-8722. Dostupné z: https://doi.org/10.1186/1756-8722-6-42.

Přehled o publikaci