MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix
perdix) Is Shaped by Selection, Recombination and Gene
Conversion

J 2013

MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion

PROMEROVÁ, Marta, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT, Josef BRYJA et. al.

Základní údaje

Originální název

MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion

Autoři

PROMEROVÁ, Marta (203 Česká republika), Tereza KRÁLOVÁ (203 Česká republika, domácí), Anna BRYJOVÁ (203 Česká republika), Tomáš ALBRECHT (203 Česká republika) a Josef BRYJA (203 Česká republika, garant, domácí)

Vydání

PLoS ONE, 2013, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.534

Kód RIV

RIV/00216224:14310/13:00069072

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0069135

UT WoS

000325211000080

Klíčová slova anglicky

MHC; Galliformes; trans-species polymorphism; Grey partridge; duplication; positive selection

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 3. 2018 15:20, Mgr. Lucie Jarošová, DiS.

Anotace

V originále

Among bird species, the most studied major histocompatibility complex (MHC) is the chicken MHC. Although the number of studies on MHC in free-ranging species is increasing, the knowledge on MHC variation in species closely related to chicken is required to understand the peculiarities of bird MHC evolution. Here we describe the variation of MHC class IIB (MHCIIB) exon 2 in a population of the Grey partridge ( Perdix perdix ), a species of high conservation concern throughout Europe and an emerging galliform model in studies of sexual selection. We found 12 alleles in 108 individuals, but in comparison to other birds surprisingly many sites show signatures of historical positive selection. Individuals displayed between two to four alleles both on genomic and complementary DNA, suggesting the presence of two functional MHCIIB loci. Recombination and gene conversion appear to be involved in generating MHCIIB diversity in the Grey partridge; two recombination breakpoints and several gene conversion events were detected. In phylogenetic analysis of galliform MHCIIB, the Grey partridge alleles do not cluster together, but are scattered through the tree instead. Thus, our results indicate that the Grey partridge MHCIIB is comparable to most other galliforms in terms of copy number and population polymorphism.

Návaznosti

MUNI/A/0888/2013, interní kód MU

Název: Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí (Akronym: BIDA3)

Investor: Masarykova univerzita, Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

PROMEROVÁ, Marta, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT a Josef BRYJA. MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion. PLoS ONE. 2013, roč. 8, č. 7, s. "nestrankovano", 10 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0069135.

@article{1120038,
   author = {Promerová, Marta and Králová, Tereza and Bryjová, Anna and Albrecht, Tomáš and Bryja, Josef},
   article_number = {7},
   doi = {http://dx.doi.org/10.1371/journal.pone.0069135},
   keywords = {MHC; Galliformes; trans-species polymorphism; Grey partridge; duplication; positive selection},
   language = {eng},
   issn = {1932-6203},
   journal = {PLoS ONE},
   title = {MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion},
   url = {http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0069135&representation=PDF},
   volume = {8},
   year = {2013}
}

TY  - JOUR
ID  - 1120038
AU  - Promerová, Marta - Králová, Tereza - Bryjová, Anna - Albrecht, Tomáš - Bryja, Josef
PY  - 2013
TI  - MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion
JF  - PLoS ONE
VL  - 8
IS  - 7
SP  - "nestrankovano"
EP  - "nestrankovano"
SN  - 19326203
KW  - MHC
KW  - Galliformes
KW  - trans-species polymorphism
KW  - Grey partridge
KW  - duplication
KW  - positive selection
UR  - http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0069135&representation=PDF
N2  - Among bird species, the most studied major histocompatibility complex (MHC) is the chicken MHC. Although the number of studies on MHC in free-ranging species is increasing, the knowledge on MHC variation in species closely related to chicken is required to understand the peculiarities of bird MHC evolution. Here we describe the variation of MHC class IIB (MHCIIB) exon 2 in a population of the Grey partridge ( Perdix perdix ), a species of high conservation concern throughout Europe and an emerging galliform model in studies of sexual selection. We found 12 alleles in 108 individuals, but in comparison to other birds surprisingly many sites show signatures of historical positive selection. Individuals displayed between two to four alleles both on genomic and complementary DNA, suggesting the presence of two functional MHCIIB loci. Recombination and gene conversion appear to be involved in generating MHCIIB diversity in the Grey partridge; two recombination breakpoints and several gene conversion events were detected. In phylogenetic analysis of galliform MHCIIB, the Grey partridge alleles do not cluster together, but are scattered through the tree instead. Thus, our results indicate that the Grey partridge MHCIIB is comparable to most other galliforms in terms of copy number and population polymorphism.
ER  -

PROMEROVÁ, Marta, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT a Josef BRYJA. MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion. \textit{PLoS ONE}. 2013, roč.~8, č.~7, s.~''nestrankovano'', 10 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0069135.

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