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@article{1120038,
author = {Promerová, Marta and Králová, Tereza and Bryjová, Anna and Albrecht, Tomáš and Bryja, Josef},
article_number = {7},
doi = {http://dx.doi.org/10.1371/journal.pone.0069135},
keywords = {MHC; Galliformes; trans-species polymorphism; Grey partridge; duplication; positive selection},
language = {eng},
issn = {1932-6203},
journal = {PLoS ONE},
title = {MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion},
url = {http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0069135&representation=PDF},
volume = {8},
year = {2013}
}
TY - JOUR
ID - 1120038
AU - Promerová, Marta - Králová, Tereza - Bryjová, Anna - Albrecht, Tomáš - Bryja, Josef
PY - 2013
TI - MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion
JF - PLoS ONE
VL - 8
IS - 7
SP - "nestrankovano"
EP - "nestrankovano"
SN - 19326203
KW - MHC
KW - Galliformes
KW - trans-species polymorphism
KW - Grey partridge
KW - duplication
KW - positive selection
UR - http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0069135&representation=PDF
N2 - Among bird species, the most studied major histocompatibility complex (MHC) is the chicken MHC. Although the number of studies on MHC in free-ranging species is increasing, the knowledge on MHC variation in species closely related to chicken is required to understand the peculiarities of bird MHC evolution. Here we describe the variation of MHC class IIB (MHCIIB) exon 2 in a population of the Grey partridge ( Perdix perdix ), a species of high conservation concern throughout Europe and an emerging galliform model in studies of sexual selection. We found 12 alleles in 108 individuals, but in comparison to other birds surprisingly many sites show signatures of historical positive selection. Individuals displayed between two to four alleles both on genomic and complementary DNA, suggesting the presence of two functional MHCIIB loci. Recombination and gene conversion appear to be involved in generating MHCIIB diversity in the Grey partridge; two recombination breakpoints and several gene conversion events were detected. In phylogenetic analysis of galliform MHCIIB, the Grey partridge alleles do not cluster together, but are scattered through the tree instead. Thus, our results indicate that the Grey partridge MHCIIB is comparable to most other galliforms in terms of copy number and population polymorphism.
ER -
PROMEROVÁ, Marta, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT a Josef BRYJA. MHC Class IIB Exon 2 Polymorphism in the Grey Partridge (Perdix perdix) Is Shaped by Selection, Recombination and Gene Conversion. \textit{PLoS ONE}. 2013, roč.~8, č.~7, s.~''nestrankovano'', 10 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0069135.
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