Dystonia and the cerebellum: A new field of interest in
movement disorders?

J 2013

Dystonia and the cerebellum: A new field of interest in movement disorders?

FILIP, Pavel; Ovidiu V LUNGU a Martin BAREŠ

Základní údaje

Originální název

Dystonia and the cerebellum: A new field of interest in movement disorders?

Autoři

FILIP, Pavel; Ovidiu V LUNGU a Martin BAREŠ

Vydání

Clinical Neurophysiology, Clare, Elsevier Ireland, 2013, 1388-2457

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.979

Kód RIV

RIV/00216224:14740/13:00065623

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1016/j.clinph.2013.01.003

UT WoS

000321488200006

Klíčová slova anglicky

Cerebellum; Dystonia; Animal models; Imaging; Pathophysiology

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 1. 2014 20:38, prof. MUDr. Martin Bareš, Ph.D.

Anotace

V originále

Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well. Even in the absence of traditional "cerebellar signs" in most dystonia patients, there are more subtle indications of cerebellar dysfunction. It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13437, projekt VaV

Název: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Citovat

FILIP, Pavel; Ovidiu V LUNGU a Martin BAREŠ. Dystonia and the cerebellum: A new field of interest in movement disorders? Clinical Neurophysiology. Clare: Elsevier Ireland, 2013, roč. 124, č. 7, s. 1269-1276. ISSN 1388-2457. Dostupné z: https://doi.org/10.1016/j.clinph.2013.01.003.

@article{1120449,
   author = {Filip, Pavel and Lungu, Ovidiu V and Bareš, Martin},
   article_location = {Clare},
   article_number = {7},
   doi = {https://doi.org/10.1016/j.clinph.2013.01.003},
   keywords = {Cerebellum; Dystonia; Animal models; Imaging; Pathophysiology},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Dystonia and the cerebellum: A new field of interest in movement disorders?},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/23422326},
   volume = {124},
   year = {2013}
}

TY  - JOUR
ID  - 1120449
AU  - Filip, Pavel - Lungu, Ovidiu V - Bareš, Martin
PY  - 2013
TI  - Dystonia and the cerebellum: A new field of interest in movement disorders?
JF  - Clinical Neurophysiology
VL  - 124
IS  - 7
SP  - 1269-1276
EP  - 1269-1276
PB  - Elsevier Ireland
SN  - 13882457
KW  - Cerebellum
KW  - Dystonia
KW  - Animal models
KW  - Imaging
KW  - Pathophysiology
UR  - http://www.ncbi.nlm.nih.gov/pubmed/23422326
L2  - http://www.ncbi.nlm.nih.gov/pubmed/23422326
N2  - Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well. Even in the absence of traditional "cerebellar signs" in most dystonia patients, there are more subtle indications of cerebellar dysfunction. It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment.
ER  -

FILIP, Pavel; Ovidiu V LUNGU a Martin BAREŠ. Dystonia and the cerebellum: A new field of interest in movement disorders? \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, 2013, roč.~124, č.~7, s.~1269-1276. ISSN~1388-2457. Dostupné z: https://doi.org/10.1016/j.clinph.2013.01.003.

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