Antiandrogenic activity of humic substances

J 2012

Antiandrogenic activity of humic substances

BITTNER, Michal; Nadine SAUL a Christian E W STEINBERG

Základní údaje

Originální název

Antiandrogenic activity of humic substances

Autoři

BITTNER, Michal; Nadine SAUL a Christian E W STEINBERG

Vydání

Science of the Total Environment, AMSTERDAM, Elsevier, 2012, 0048-9697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.258

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/12:00069145

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.scitotenv.2012.05.056

UT WoS

000308270700010

Klíčová slova anglicky

Humic substances; Hormone-like effect; Antiandrogenic pathway

Štítky

AKR, rivok

Změněno: 10. 7. 2017 13:25, RNDr. Mgr. Michal Bittner, Ph.D.

Anotace

V originále

For long, natural organic matter (NOM) composed mainly of humic substances (HS) were regarded as inert in the ecosystems with respect to their possible chemical interaction with exposed organisms. However recently, NOM have been shown to elicit various adverse effects generally attributed to synthetic xenobiotics, including estrogenic effects translating into shifts of the gender ratios in populations. However, the anti/androgenic pathway was not yet evaluated. Here, we applied an anti/androgenic sensitive cell line MDA stably transfected with the firefly luciferase gene under transcriptional control of the androgen responsive element. With five out of twelve tested NOM preparations, particularly with soil and coal isolates, we identified a relatively high, concentration-dependent antiandrogenic effect. This appears to be the first study to show this endocrine disrupting pathway for a ubiquitous biogeochemical matrix, a potential activity which should not be neglected in forthcoming studies on synthetic endocrine disruptors in the environment.

Návaznosti

ED0001/01/01, projekt VaV

Název: CETOCOEN

MSM0021622412, záměr

Název: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Akronym: INCHEMBIOL)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální , regionální a lokální úrovni

Citovat

BITTNER, Michal; Nadine SAUL a Christian E W STEINBERG. Antiandrogenic activity of humic substances. Science of the Total Environment. AMSTERDAM: Elsevier, 2012, roč. 432, č. 2012, s. 93-96. ISSN 0048-9697. Dostupné z: https://doi.org/10.1016/j.scitotenv.2012.05.056.

@article{1120980,
   author = {Bittner, Michal and Saul, Nadine and Steinberg, Christian E W},
   article_location = {AMSTERDAM},
   article_number = {2012},
   doi = {https://doi.org/10.1016/j.scitotenv.2012.05.056},
   keywords = {Humic substances; Hormone-like effect; Antiandrogenic pathway},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Antiandrogenic activity of humic substances},
   volume = {432},
   year = {2012}
}

TY  - JOUR
ID  - 1120980
AU  - Bittner, Michal - Saul, Nadine - Steinberg, Christian E W
PY  - 2012
TI  - Antiandrogenic activity of humic substances
JF  - Science of the Total Environment
VL  - 432
IS  - 2012
SP  - 93-96
EP  - 93-96
PB  - Elsevier
SN  - 00489697
KW  - Humic substances
KW  - Hormone-like effect
KW  - Antiandrogenic pathway
N2  - For long, natural organic matter (NOM) composed mainly of humic substances (HS) were regarded as inert in the ecosystems with respect to their possible chemical interaction with exposed organisms. However recently, NOM have been shown to elicit various adverse effects generally attributed to synthetic xenobiotics, including estrogenic effects translating into shifts of the gender ratios in populations. However, the anti/androgenic pathway was not yet evaluated. Here, we applied an anti/androgenic sensitive cell line MDA stably transfected with the firefly luciferase gene under transcriptional control of the androgen responsive element. With five out of twelve tested NOM preparations, particularly with soil and coal isolates, we identified a relatively high, concentration-dependent antiandrogenic effect. This appears to be the first study to show this endocrine disrupting pathway for a ubiquitous biogeochemical matrix, a potential activity which should not be neglected in forthcoming studies on synthetic endocrine disruptors in the environment.
ER  -

BITTNER, Michal; Nadine SAUL a Christian E W STEINBERG. Antiandrogenic activity of humic substances. \textit{Science of the Total Environment}. AMSTERDAM: Elsevier, 2012, roč.~432, č.~2012, s.~93-96. ISSN~0048-9697. Dostupné z: https://doi.org/10.1016/j.scitotenv.2012.05.056.

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