REKTOR, Ivan, Jan TOMČÍK, Michal MIKL, Radek MAREČEK, Milan BRÁZDIL a Irena REKTOROVÁ. Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy. BRAIN TOPOGRAPHY, DORDRECHT: SPRINGER, 2013, roč. 26, č. 2, s. 355-362. ISSN 0896-0267. doi:10.1007/s10548-012-0272-8.
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Základní údaje
Originální název Association Between the Basal Ganglia and Large-Scale Brain Networks in Epilepsy
Autoři REKTOR, Ivan (203 Česká republika, garant, domácí), Jan TOMČÍK (203 Česká republika), Michal MIKL (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, domácí).
Vydání BRAIN TOPOGRAPHY, DORDRECHT, SPRINGER, 2013, 0896-0267.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 3. Medical and Health Sciences
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 2.519
Kód RIV RIV/00216224:14740/13:00066443
Organizační jednotka Středoevropský technologický institut
Doi http://dx.doi.org/10.1007/s10548-012-0272-8
UT WoS 000323910200012
Klíčová slova anglicky Basal ganglia; Putamen; Epilepsy; Default mode network; Somatomotor cortex; correlation
Štítky ok, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Olga Křížová, učo 56639. Změněno: 25. 4. 2014 16:44.
Anotace
Epilepsy may affect connectivity between the putamen and cortex even during the resting state. Putamen is part of the basal ganglia resting state network (BG-RSN) which is anti-correlated with the default mode network (DMN) in healthy subjects. Therefore, we aimed at studying the functional brain connectivity (FC) of the putamen with the cortical areas engaged in theDMNas well as with the primary somatomotor cortex which is a cortical region engaged in the BG-RSN. We compared the data obtained in patients with epilepsy with that in healthy controls (HC). Functional magnetic resonance imaging (fMRI) was performed in 10 HC and 24 patients with epilepsy: 14 patients with extratemporal epilepsy (PE) and 10 patients with temporal epilepsy (PT). Resting state fMRI datawas obtained using the 1.5 T Siemens Symphony scanner. TheGroup ICA of fMRI Toolbox (GIFT) program was used for independent component analysis. The component representing the DMN was chosen according to a spatial correlation with a mask typical for DMN. The FC between the putamen and the primary somatomotor cortex was studied to assess the connectivity of the putamen within the BG-RSN. A second-level analysis was calculated to evaluate differences among the groups using SPM software. In patients with epilepsy as compared toHC, the magnitude of anti-correlation between the putamen and brain regions engaged in the DMN was significantly lower. In fact, the correlation changed the connectivity direction from negative inHC to positive in PE and PT. The disturbed FC of the BG in patients with epilepsy as compared with HC was further illustrated by a significant decrease in connectivity between the left/right putamen and the left/right somatomotor cortex, i.e. between regions that are engaged in the BG-RSN. The FC between the putamen and the cortex is disturbed in patients with epilepsy.Thismay reflect an altered function of theBGin epilepsy.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
GAP304/11/1318, projekt VaVNázev: Optimalizace metodiky analýzy a hodnocení simultánního EEG-fMRI u pacientů s farmakorezistentní epilepsií
Investor: Grantová agentura ČR, Standardní projekty
VytisknoutZobrazeno: 18. 10. 2019 23:25