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@article{1126819,
author = {Kollar, Peter and Bárta, Tomáš and Hošek, Jan and Souček, Karel and Müller Závalová, Veronika and Artinian, Shushan and Talhouk, Rabih and Šmejkal, Karel and Suchý, Pavel Jr. and Hampl, Aleš},
article_location = {NEW YORK},
article_number = {350519},
doi = {http://dx.doi.org/10.1155/2013/350519},
keywords = {ROOT BARK; DIMETHYL-SULFOXIDE; IN-VITRO; KAPPA-B; CANCER; APOPTOSIS; DEATH; LINE; DIFFERENTIATION; PROGRESSION},
language = {eng},
issn = {1741-427X},
journal = {EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE},
title = {Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response},
volume = {2013},
year = {2013}
}
TY - JOUR
ID - 1126819
AU - Kollar, Peter - Bárta, Tomáš - Hošek, Jan - Souček, Karel - Müller Závalová, Veronika - Artinian, Shushan - Talhouk, Rabih - Šmejkal, Karel - Suchý, Pavel Jr. - Hampl, Aleš
PY - 2013
TI - Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response
JF - EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
VL - 2013
IS - 350519
SP - 1-13
EP - 1-13
PB - HINDAWI PUBLISHING CORPORATION
SN - 1741427X
KW - ROOT BARK
KW - DIMETHYL-SULFOXIDE
KW - IN-VITRO
KW - KAPPA-B
KW - CANCER
KW - APOPTOSIS
KW - DEATH
KW - LINE
KW - DIFFERENTIATION
KW - PROGRESSION
N2 - Morus alba L. (MA) is a natural source of many compounds with different biological effects. It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities. The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA(kuwanon E, cudraflavone B, and 4'-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells. Anti-inflammatory effects were also determined for all three given flavonoids. Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography. From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells. Kuwanon E and 4'-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types. Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds. Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively.
ER -
KOLLAR, Peter, Tomáš BÁRTA, Jan HOŠEK, Karel SOUČEK, Veronika MÜLLER ZÁVALOVÁ, Shushan ARTINIAN, Rabih TALHOUK, Karel ŠMEJKAL, Pavel Jr. SUCHÝ a Aleš HAMPL. Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response. \textit{EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE}. NEW YORK: HINDAWI PUBLISHING CORPORATION, 2013, roč.~2013, č.~350519, s.~1-13. ISSN~1741-427X. Dostupné z: https://dx.doi.org/10.1155/2013/350519.
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