Vitamin D and cardiovascular diseases

J 2013

Vitamin D and cardiovascular diseases

MATĚJOVSKÁ KUBEŠOVÁ, Hana; Pavel WEBER; Katarína BIELAKOVÁ; Emmanuela FERNANDOVÁ; J. MATEJOVSKY et al.

Základní údaje

Originální název

Vitamin D and cardiovascular diseases

Autoři

MATĚJOVSKÁ KUBEŠOVÁ, Hana; Pavel WEBER; Katarína BIELAKOVÁ; Emmanuela FERNANDOVÁ; J. MATEJOVSKY; Vlasta POLCAROVÁ a Hana MELUZÍNOVÁ

Vydání

Journal of Aging Research & Clinical Practice, Toulouse, Celsius, 2013, 2258-8094

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00069848

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

vitamin D; vitamin D receptor; hypertension; ischemic heart disease; cardiac failure

Změněno: 22. 10. 2013 17:39, Soňa Böhmová

Anotace

V originále

A lot of attention is paid to vitamin D in the last few years due to its broader spectrum of influence in human organs. Nuclear vitamin D receptors (VDR) are proved to be a main mechanism of action. More and more evidence of the negative influence of vitamin D deficiency on cardiovascular system appears together with low vitamin D serum levels in the current population, mostly due to life style with little exposure of unprotected skin to sun light. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. There is no evidence of any association of vitamin D and cholesterol levels, on the other hand normal level of vitamin D helps to keep the triglyceride serum concentration in normal range. Hypertension is influenced negatively by low level of vitamin D due to stimulation of renin-angiotensin-aldosteron system, parathormon secretion and lower antiiflammatory and vasculoprotective effect. The course of cardiovascular diseases can be positively modulated by keeping vitamin D level within normal range. The adequate exposure of unprotected skin to sun is recommended as natural suplement and effective source of vitamin D.

Citovat

MATĚJOVSKÁ KUBEŠOVÁ, Hana; Pavel WEBER; Katarína BIELAKOVÁ; Emmanuela FERNANDOVÁ; J. MATEJOVSKY; Vlasta POLCAROVÁ a Hana MELUZÍNOVÁ. Vitamin D and cardiovascular diseases. Journal of Aging Research & Clinical Practice. Toulouse: Celsius, 2013, roč. 2, č. 3, s. 271-275. ISSN 2258-8094.

@article{1126905,
   author = {Matějovská Kubešová, Hana and Weber, Pavel and Bielaková, Katarína and Fernandová, Emmanuela and Matejovsky, J. and Polcarová, Vlasta and Meluzínová, Hana},
   article_location = {Toulouse},
   article_number = {3},
   keywords = {vitamin D; vitamin D receptor; hypertension; ischemic heart disease; cardiac failure},
   language = {eng},
   issn = {2258-8094},
   journal = {Journal of Aging Research & Clinical Practice},
   title = {Vitamin D and cardiovascular diseases},
   volume = {2},
   year = {2013}
}

TY  - JOUR
ID  - 1126905
AU  - Matějovská Kubešová, Hana - Weber, Pavel - Bielaková, Katarína - Fernandová, Emmanuela - Matejovsky, J. - Polcarová, Vlasta - Meluzínová, Hana
PY  - 2013
TI  - Vitamin D and cardiovascular diseases
JF  - Journal of Aging Research & Clinical Practice
VL  - 2
IS  - 3
SP  - 271-275
EP  - 271-275
PB  - Celsius
SN  - 22588094
KW  - vitamin D
KW  - vitamin D receptor
KW  - hypertension
KW  - ischemic heart disease
KW  - cardiac failure
N2  - A lot of attention is paid to vitamin D in the last few years due to its broader spectrum of influence in human organs. Nuclear vitamin D receptors (VDR) are proved to be a main mechanism of action. More and more evidence of the negative influence of vitamin D deficiency on cardiovascular system appears together with low vitamin D serum levels in the current population, mostly due to life style with little exposure of unprotected skin to sun light. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. There is no evidence of any association of vitamin D and cholesterol levels, on the other hand normal level of vitamin D helps to keep the triglyceride serum concentration in normal range. Hypertension is influenced negatively by low level of vitamin D due to stimulation of renin-angiotensin-aldosteron system, parathormon secretion and lower antiiflammatory and vasculoprotective effect. The course of cardiovascular diseases can be positively modulated by keeping vitamin D level within normal range. The adequate exposure of unprotected skin to sun is recommended as natural suplement and effective source of vitamin D.
ER  -

MATĚJOVSKÁ KUBEŠOVÁ, Hana; Pavel WEBER; Katarína BIELAKOVÁ; Emmanuela FERNANDOVÁ; J. MATEJOVSKY; Vlasta POLCAROVÁ a Hana MELUZÍNOVÁ. Vitamin D and cardiovascular diseases. \textit{Journal of Aging Research \&{} Clinical Practice}. Toulouse: Celsius, 2013, roč.~2, č.~3, s.~271-275. ISSN~2258-8094.

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