Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach

DWYER, Michael P.; Kartick KEERTIKAR; Kamil PARUCH; Carmen ALVAREZ; Marc LABROLI; Cory POKER; Thierry O. FISHMANN; Rosemary MAYER-EZEL; Richard BOND; Yan WANG; Rita AZEVEDO and Timothy J. GUZI. Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. Oxford, 2013, vol. 23, No 22, p. 6178-6182. ISSN 0960-894X. Available from: https://doi.org/10.1016/j.bmcl.2013.08.110.

Basic information

Original name

Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach

Authors

DWYER, Michael P.; Kartick KEERTIKAR; Kamil PARUCH; Carmen ALVAREZ; Marc LABROLI; Cory POKER; Thierry O. FISHMANN; Rosemary MAYER-EZEL; Richard BOND; Yan WANG; Rita AZEVEDO and Timothy J. GUZI

Edition

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Oxford, 2013, 0960-894X

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Other information

Language

English

Type of outcome

Article in a journal

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 2.331

Organization unit

Faculty of Science

DOI

https://doi.org/10.1016/j.bmcl.2013.08.110

UT WoS

000325760300029

Keywords in English

Pan–Pim kinase pyrazolo[1,5-a]pyrimidine

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Abstract

In the original language

The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan–Pim inhibitors such as 11j are described.