Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in
relationship to factors describing rheumatoid arthritis

a 2013

Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in relationship to factors describing rheumatoid arthritis

LIPKOVÁ, Jolana; Anna VAŠKŮ a Monika GOLDBERGOVÁ

Základní údaje

Originální název

Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in relationship to factors describing rheumatoid arthritis

Název česky

Polymorfismy v genech pro TIMP1, TIMP2 a TIMP3 ve vztahu k faktorům popisujícím revmatoidní artritdu

Autoři

LIPKOVÁ, Jolana ; Anna VAŠKŮ a Monika GOLDBERGOVÁ

Vydání

2013

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

revmatoidní artritida, polymorfismus, geny pro TIMP

Klíčová slova anglicky

rheumatoid arthritis, polymorphism, genes for TIMP

Příznaky

Mezinárodní význam

Změněno: 11. 12. 2013 15:04, Mgr. Jolana Lipková, Ph.D.

Anotace

V originále

Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with synovial inflammation, progressive cartilage and bone destruction. A hallmark of joint destruction in RA is degradation of collagens, and other extracellular matrix components. The group of matrix degrading enzymes matrix metallo-proteinases (MMPs) and their tissue specific inhibitors (TIMPs) play crucial role in processes of tissue remodeling, join destruction and progression of RA. In a case-control study, we explored relation between three polymorphisms in non-coding areas of TIMP1, TIMP2 and TIMP3 genes and rheumatoid arthritis, with respect to RA. A total of 94 patients with rheumatoid arthritis and 290 control subjects were genotyped for G/C intron TIMP1polymorphism (rs5953060), A/G intron TIMP2 polymorphism (rs8176329) and C/T 3UTR TIMP3 polymorphism (rs1065314). No significant differences in genotype distribution and/or allele frequencies were observed when comparing patients with rheumatoid arthritis and controls. Within the RA patient we have found significant association between studied polymorphism in TIMP1 and levels of anti-CCP (p=0.047), rheumatoid factor (RF) (p=0.06), IL-15 (p=0.02) and IL-6 (p=0.06). Regarding the levels of pro-inflammatory IL-15 and IL-6, the highest concentration was found in patients homozygous for G allele. Furthermore, association of TIMP3 polymorphism and distinct RF: RF IgM (p=0.08), RF IgA(p=0.04), RF IgG (p=0.01) and FW (p=0.06) have been observed. In case of TIMP2 no association to factors of RA was found. In conclusion, the TIMP polymorphisms were not associated to RA, but TIMP-1 and TIMP3 were related to pro-inflammatory cytokines levels in circulation and to RF and anti-CCP, respectively.

Citovat

LIPKOVÁ, Jolana; Anna VAŠKŮ a Monika GOLDBERGOVÁ. Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in relationship to factors describing rheumatoid arthritis. 2013.

@proceedings{1136164,
   author = {Lipková, Jolana and Vašků, Anna and Goldbergová, Monika},
   keywords = {rheumatoid arthritis, polymorphism, genes for TIMP},
   language = {eng},
   title = {Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in relationship to factors describing rheumatoid arthritis},
   year = {2013}
}

TY  - CONF
ID  - 1136164
AU  - Lipková, Jolana - Vašků, Anna - Goldbergová, Monika
PY  - 2013
TI  - Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in relationship to factors describing rheumatoid arthritis
KW  - rheumatoid arthritis, polymorphism, genes for TIMP
N2  - Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with synovial inflammation, progressive cartilage and bone destruction. A hallmark of joint destruction in RA is degradation of collagens, and other extracellular matrix components. The group of matrix degrading enzymes matrix metallo-proteinases (MMPs) and their tissue specific inhibitors (TIMPs) play crucial role in processes of tissue remodeling, join destruction and progression of RA. In a case-control study, we explored relation between three polymorphisms in non-coding areas of TIMP1, TIMP2 and TIMP3 genes and rheumatoid arthritis, with respect to RA. A total of 94 patients with rheumatoid arthritis and 290 control subjects were genotyped for G/C intron TIMP1polymorphism (rs5953060), A/G intron TIMP2 polymorphism (rs8176329) and C/T 3UTR TIMP3 polymorphism (rs1065314). No significant differences in genotype distribution and/or allele frequencies were observed when comparing patients with rheumatoid arthritis and controls. Within the RA patient we have found significant association between studied polymorphism in TIMP1 and levels of anti-CCP (p=0.047), rheumatoid factor (RF) (p=0.06), IL-15 (p=0.02) and IL-6 (p=0.06). Regarding the levels of pro-inflammatory IL-15 and IL-6, the highest concentration was found in patients homozygous for G allele. Furthermore, association of TIMP3 polymorphism and distinct RF: RF IgM (p=0.08), RF IgA(p=0.04), RF IgG (p=0.01) and FW (p=0.06) have been observed. In case of TIMP2 no association to factors of RA was found. In conclusion, the TIMP polymorphisms were not associated to RA, but TIMP-1 and TIMP3 were related to pro-inflammatory cytokines levels in circulation and to RF and anti-CCP, respectively.
ER  -

LIPKOVÁ, Jolana; Anna VAŠKŮ a Monika GOLDBERGOVÁ. \textit{Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 in relationship to factors describing rheumatoid arthritis}. 2013.

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