Další formáty:
BibTeX
LaTeX
RIS
@proceedings{1137326,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
booktitle = {63. Česko-Slovenské Farmakologické dny},
keywords = {ethanol; acetaldehyde; inward rectifier; rat ventricular myocytes; patch clamp},
language = {eng},
title = {Ethanol and its principle metabolite acetaldehyde affect inward rectifier potassium current IK1 in rat ventricular myocytes},
year = {2013}
}
TY - CONF
ID - 1137326
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2013
TI - Ethanol and its principle metabolite acetaldehyde affect inward rectifier potassium current IK1 in rat ventricular myocytes
KW - ethanol
KW - acetaldehyde
KW - inward rectifier
KW - rat ventricular myocytes
KW - patch clamp
N2 - Alcohol intoxication may induce arrhythmias, most frequently the atrial fibrillation (AF). Increase of inward rectifier potassium currents including the voltage-gated current IK1 is known to play an important role in the pathogenesis of AF. Data describing effects of ethanol and its principle metabolite acetaldehyde on mammalian IK1 are rare and controversial. Hence, we aimed to analyse IK1-changes in the presence of ethanol (0.2 – 200 mM) and acetaldehyde (3 – 300 microM) in enzymatically isolated rat right ventricular myocytes by the whole cell patch clamp technique at room temperature. We conclude that ethanol exerts a dual effect on the cardiac IK1. Inhibition of IK1 in some cells and its stimulation in others might result in the heterogeneity of cardiac repolarization with possible arrhythmogenic consequences. It is unlikely that, in healthy humans, acetaldehyde significantly contributes to the arrhythmogenesis observed after the alcohol consumption.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Ethanol and its principle metabolite acetaldehyde affect inward rectifier potassium current IK1 in rat ventricular myocytes. In \textit{63. Česko-Slovenské Farmakologické dny}. 2013. ISSN~1213-8118.
|
