Sarcosine as a Potential Prostate Cancer Biomarker-A Review

J 2013

Sarcosine as a Potential Prostate Cancer Biomarker-A Review

CERNEI, Natalia Vladimirovna, Zbynek HEGER, Jaromír GUMULEC, Ondřej ZITKA, Michal MASAŘÍK et. al.

Základní údaje

Originální název

Sarcosine as a Potential Prostate Cancer Biomarker-A Review

Autoři

CERNEI, Natalia Vladimirovna (498 Moldavsko), Zbynek HEGER (203 Česká republika), Jaromír GUMULEC (203 Česká republika, domácí), Ondřej ZITKA (203 Česká republika), Michal MASAŘÍK (203 Česká republika, garant, domácí), Petr BABULA (203 Česká republika), Tomas ECKSCHLAGER (203 Česká republika), Marie STIBOROVA (203 Česká republika), Rene KIZEK (203 Česká republika) a Vojtech ADAM (203 Česká republika)

Vydání

International Journal of Molecular Sciences, Basel, MDPI Center, 2013, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.339

Kód RIV

RIV/00216224:14110/13:00070630

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/ijms140713893

UT WoS

000322171700060

Klíčová slova anglicky

cancer of prostate; biomarkers; early diagnostic; prostatic specific antigen; non-invasive markers; urine; amino acids

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 12. 2013 18:11, Soňa Böhmová

Anotace

V originále

Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there is great interest in the finding of new markers including amino acids, proteins or nucleic acids. Prostate specific antigen (PSA) is commonly used and is the most important biomarker of CaP. This marker can only be detected in blood and its sensitivity is approximately 80%. Moreover, early stages cannot be diagnosed using this protein. Currently, there does not exist a test for diagnosis of early stages of prostate cancer. This fact motivates us to find markers sensitive to the early stages of CaP, which are easily detected in body fluids including urine. A potential is therefore attributed to the non-protein amino acid sarcosine, which is generated by glycine-N-methyltransferase in its biochemical cycle. In this review, we summarize analytical methods for quantification of sarcosine as a CaP marker. Moreover, pathways of the connection of synthesis of sarcosine and CaP development are discussed.

Citovat

CERNEI, Natalia Vladimirovna, Zbynek HEGER, Jaromír GUMULEC, Ondřej ZITKA, Michal MASAŘÍK, Petr BABULA, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK a Vojtech ADAM. Sarcosine as a Potential Prostate Cancer Biomarker-A Review. International Journal of Molecular Sciences. Basel: MDPI Center, 2013, roč. 14, č. 7, s. 13893-13908. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms140713893.

@article{1137570,
   author = {Cernei, Natalia Vladimirovna and Heger, Zbynek and Gumulec, Jaromír and Zitka, Ondřej and Masařík, Michal and Babula, Petr and Eckschlager, Tomas and Stiborova, Marie and Kizek, Rene and Adam, Vojtech},
   article_location = {Basel},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/ijms140713893},
   keywords = {cancer of prostate; biomarkers; early diagnostic; prostatic specific antigen; non-invasive markers; urine; amino acids},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Sarcosine as a Potential Prostate Cancer Biomarker-A Review},
   volume = {14},
   year = {2013}
}

TY  - JOUR
ID  - 1137570
AU  - Cernei, Natalia Vladimirovna - Heger, Zbynek - Gumulec, Jaromír - Zitka, Ondřej - Masařík, Michal - Babula, Petr - Eckschlager, Tomas - Stiborova, Marie - Kizek, Rene - Adam, Vojtech
PY  - 2013
TI  - Sarcosine as a Potential Prostate Cancer Biomarker-A Review
JF  - International Journal of Molecular Sciences
VL  - 14
IS  - 7
SP  - 13893-13908
EP  - 13893-13908
PB  - MDPI Center
SN  - 14220067
KW  - cancer of prostate
KW  - biomarkers
KW  - early diagnostic
KW  - prostatic specific antigen
KW  - non-invasive markers
KW  - urine
KW  - amino acids
N2  - Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there is great interest in the finding of new markers including amino acids, proteins or nucleic acids. Prostate specific antigen (PSA) is commonly used and is the most important biomarker of CaP. This marker can only be detected in blood and its sensitivity is approximately 80%. Moreover, early stages cannot be diagnosed using this protein. Currently, there does not exist a test for diagnosis of early stages of prostate cancer. This fact motivates us to find markers sensitive to the early stages of CaP, which are easily detected in body fluids including urine. A potential is therefore attributed to the non-protein amino acid sarcosine, which is generated by glycine-N-methyltransferase in its biochemical cycle. In this review, we summarize analytical methods for quantification of sarcosine as a CaP marker. Moreover, pathways of the connection of synthesis of sarcosine and CaP development are discussed.
ER  -

CERNEI, Natalia Vladimirovna, Zbynek HEGER, Jaromír GUMULEC, Ondřej ZITKA, Michal MASAŘÍK, Petr BABULA, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK a Vojtech ADAM. Sarcosine as a Potential Prostate Cancer Biomarker-A Review. \textit{International Journal of Molecular Sciences}. Basel: MDPI Center, 2013, roč.~14, č.~7, s.~13893-13908. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms140713893.

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