Další formáty:
BibTeX
LaTeX
RIS
@proceedings{1138017, author = {Hernangómez Herrero, Miriam and Dubový, Petr and Hradilová Svíženská, Ivana and Klusáková, Ilona}, booktitle = {4th International Congress on Neuropathic pain, Toronto}, keywords = {microglial cells, dorsal root ganglia, attenuation of neuropathic pain}, language = {eng}, title = {CHANGES IN CD200 AND CD200R EXPRESSION IN TWO RAT MODELS OF NEUROPATHIC PAIN}, year = {2013} }
TY - CONF ID - 1138017 AU - Hernangómez Herrero, Miriam - Dubový, Petr - Hradilová Svíženská, Ivana - Klusáková, Ilona PY - 2013 TI - CHANGES IN CD200 AND CD200R EXPRESSION IN TWO RAT MODELS OF NEUROPATHIC PAIN KW - microglial cells, dorsal root ganglia, attenuation of neuropathic pain N2 - Background and aim. The existence of CD200 in glial cells and neurons of the central nervous system is well-known, but there is limited information on the distribution of CD200 and CD200R in the peripheral nervous system. Here, we investigate bilateral changes of CD200 and CD200R expression in L4-L5 dorsal root ganglia (DRG) after chronic constriction (CCI) or spare nerve (SNI) injury of the sciatic nerve used as neuropathic pain models. Method. Rats undergoing unilateral CCI and SNI were left to survive for 3, 7 or 14 days, sham-operated rats for 3 or 14 days. Neuropathic pain induction was tested by measurement of mechanoallodynia and thermal hyperalgesia. After the survival time, L4-L5 DRG were removed bilaterally from naive, operated, and sham-operated rats and CD200 and CD200R proteins were detected by immunohistochemical staining. Results. Unilateral SNI induced a transient bilateral increase of CD200 protein levels in satellite glial cells after 3 days while immunostaining was reduced following 14 days from operation. In contrast, CD200 immunofluorescence was elevated bilaterally in DRG mainly after 14 days from CCI operation. Furthermore, CD200R expression was enhanced in DRG after 7 days from SNI and CCI operations compared with naive animals. Conclusion. Our results suggest that CD200/CD200R might play an inhibitory role of neuroinflammatory reactions in the DRG to keep homeostasis after neuropathic stress. ER -
HERNANGÓMEZ HERRERO, Miriam, Petr DUBOVÝ, Ivana HRADILOVÁ SVÍŽENSKÁ a Ilona KLUSÁKOVÁ. CHANGES IN CD200 AND CD200R EXPRESSION IN TWO RAT MODELS OF NEUROPATHIC PAIN. In \textit{4th International Congress on Neuropathic pain, Toronto}. 2013.
|