| ŠERÝ, Omar, Jana POVOVÁ, Ivan MÍŠEK, Lukáš PEŠÁK a Vladimír JANOUT. Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review. Folia Neuropathologica. 2013, roč. 51, č. 1, s. 1-9. ISSN 1641-4640. Dostupné z: https://dx.doi.org/10.5114/fn.2013.34190. |
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@article{1139036,
author = {Šerý, Omar and Povová, Jana and Míšek, Ivan and Pešák, Lukáš and Janout, Vladimír},
article_number = {1},
doi = {http://dx.doi.org/10.5114/fn.2013.34190},
keywords = {Alzheimer`s disease; amyloid precursor protein; tau protein; apolipoprotein E},
language = {eng},
issn = {1641-4640},
journal = {Folia Neuropathologica},
title = {Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review},
volume = {51},
year = {2013}
}
TY - JOUR
ID - 1139036
AU - Šerý, Omar - Povová, Jana - Míšek, Ivan - Pešák, Lukáš - Janout, Vladimír
PY - 2013
TI - Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review
JF - Folia Neuropathologica
VL - 51
IS - 1
SP - 1-9
EP - 1-9
SN - 16414640
KW - Alzheimer`s disease
KW - amyloid precursor protein
KW - tau protein
KW - apolipoprotein E
N2 - More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.
ER -
ŠERÝ, Omar, Jana POVOVÁ, Ivan MÍŠEK, Lukáš PEŠÁK a Vladimír JANOUT. Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review. \textit{Folia Neuropathologica}. 2013, roč.~51, č.~1, s.~1-9. ISSN~1641-4640. Dostupné z: https://dx.doi.org/10.5114/fn.2013.34190.
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