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@article{1139234,
author = {RuttkayandNedecky, Branislav and Jimenez, Ana Maria Jimenez and Nejdl, Lukas and Chudobova, Dagmar and Gumulec, Jaromír and Masařík, Michal and Adam, Vojtech and Kizek, Rene},
article_location = {Athens},
article_number = {6},
doi = {http://dx.doi.org/10.3892/ijo.2013.2105},
keywords = {human papillomavirus; head and neck cancer; metallothionein; protein p53; zinc finger proteins},
language = {eng},
issn = {1019-6439},
journal = {International Journal of Oncology},
title = {Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review)},
volume = {43},
year = {2013}
}
TY - JOUR
ID - 1139234
AU - Ruttkay-Nedecky, Branislav - Jimenez, Ana Maria Jimenez - Nejdl, Lukas - Chudobova, Dagmar - Gumulec, Jaromír - Masařík, Michal - Adam, Vojtech - Kizek, Rene
PY - 2013
TI - Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review)
JF - International Journal of Oncology
VL - 43
IS - 6
SP - 1754-1762
EP - 1754-1762
PB - Spandidos Publications
SN - 10196439
KW - human papillomavirus
KW - head and neck cancer
KW - metallothionein
KW - protein p53
KW - zinc finger proteins
N2 - Human papillomaviruses (HPV) are small circular, double-stranded DNA viruses infecting epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than 120 different identified types of HPV, the majority are involved in infections of the genital tract, cancer of the cervix, vulva, vagina and penis, and of non-anogenital localizations, such as the head and neck areas. From the point of view of the infection, human papillomaviruses have developed several molecular mechanisms to enable infected cells to suppress apoptosis. This review provides a comprehensive and critical summary of the current literature that focuses on cervical carcinoma and cancer of the head and neck caused by HPV. In particular, we discuss HPV virology, the molecular mechanisms of carcinogenesis, the role of the tumor suppressor protein p53 and the E6/E7 zinc finger proteins. Classification of HPV according to diagnosis is also described.
ER -
RUTTKAY-NEDECKY, Branislav, Ana Maria Jimenez JIMENEZ, Lukas NEJDL, Dagmar CHUDOBOVA, Jaromír GUMULEC, Michal MASAŘÍK, Vojtech ADAM a Rene KIZEK. Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review). \textit{International Journal of Oncology}. Athens: Spandidos Publications, 2013, roč.~43, č.~6, s.~1754-1762. ISSN~1019-6439. Dostupné z: https://dx.doi.org/10.3892/ijo.2013.2105.
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