A novel insight into the cardiotoxicity of antineoplastic drug
doxorubicin

J 2013

A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin

HEGER, Zbynek, Natalia CERNEI, Jiri KUDR, Jaromír GUMULEC, Iva BLAZKOVA et. al.

Základní údaje

Originální název

A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin

Autoři

HEGER, Zbynek (203 Česká republika), Natalia CERNEI (203 Česká republika), Jiri KUDR (203 Česká republika), Jaromír GUMULEC (203 Česká republika, garant, domácí), Iva BLAZKOVA (203 Česká republika), Ondrej ZITKA (203 Česká republika), Tomas ECKSCHLAGER (203 Česká republika), Marie STIBOROVA (203 Česká republika), Vojtech ADAM (203 Česká republika) a Rene KIZEK (203 Česká republika)

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2013, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.339

Kód RIV

RIV/00216224:14110/13:00070887

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/ijms141121629

UT WoS

000328624400027

Klíčová slova anglicky

Amide bond; Cardiomyopathy; Interaction; Ion-exchange liquid chromatography; Myocardium; Spectrophotometry

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 2. 2014 10:48, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, beta-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

HEGER, Zbynek, Natalia CERNEI, Jiri KUDR, Jaromír GUMULEC, Iva BLAZKOVA, Ondrej ZITKA, Tomas ECKSCHLAGER, Marie STIBOROVA, Vojtech ADAM a Rene KIZEK. A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2013, roč. 14, č. 11, s. 21629-21646. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms141121629.

@article{1139239,
   author = {Heger, Zbynek and Cernei, Natalia and Kudr, Jiri and Gumulec, Jaromír and Blazkova, Iva and Zitka, Ondrej and Eckschlager, Tomas and Stiborova, Marie and Adam, Vojtech and Kizek, Rene},
   article_location = {Basel},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/ijms141121629},
   keywords = {Amide bond; Cardiomyopathy; Interaction; Ion-exchange liquid chromatography; Myocardium; Spectrophotometry},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin},
   volume = {14},
   year = {2013}
}

TY  - JOUR
ID  - 1139239
AU  - Heger, Zbynek - Cernei, Natalia - Kudr, Jiri - Gumulec, Jaromír - Blazkova, Iva - Zitka, Ondrej - Eckschlager, Tomas - Stiborova, Marie - Adam, Vojtech - Kizek, Rene
PY  - 2013
TI  - A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin
JF  - International Journal of Molecular Sciences
VL  - 14
IS  - 11
SP  - 21629-21646
EP  - 21629-21646
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - Amide bond
KW  - Cardiomyopathy
KW  - Interaction
KW  - Ion-exchange liquid chromatography
KW  - Myocardium
KW  - Spectrophotometry
N2  - Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, beta-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.
ER  -

HEGER, Zbynek, Natalia CERNEI, Jiri KUDR, Jaromír GUMULEC, Iva BLAZKOVA, Ondrej ZITKA, Tomas ECKSCHLAGER, Marie STIBOROVA, Vojtech ADAM a Rene KIZEK. A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2013, roč.~14, č.~11, s.~21629-21646. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms141121629.

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