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@article{1159229,
author = {Bosák, Juraj and Micenková, Lenka and Vrba, Martin and Ševčíková, Alena and Dědičová, Daniela and Garzetti, Debora and Šmajs, David},
article_location = {PUBLIC LIBRARY SCIENCE},
article_number = {12},
doi = {http://dx.doi.org/10.1371/journal.pone.0081829},
keywords = {Colicin FY; Yersinia enterocolitica},
language = {eng},
issn = {1932-6203},
journal = {Plos One},
title = {Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible},
volume = {8},
year = {2013}
}
TY - JOUR
ID - 1159229
AU - Bosák, Juraj - Micenková, Lenka - Vrba, Martin - Ševčíková, Alena - Dědičová, Daniela - Garzetti, Debora - Šmajs, David
PY - 2013
TI - Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible
JF - Plos One
VL - 8
IS - 12
SP - e81829
EP - e81829
PB - SAN FRANCISCO
SN - 19326203
KW - Colicin FY
KW - Yersinia enterocolitica
N2 - Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY.
ER -
BOSÁK, Juraj, Lenka MICENKOVÁ, Martin VRBA, Alena ŠEVČÍKOVÁ, Daniela DĚDIČOVÁ, Debora GARZETTI a David ŠMAJS. Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible. \textit{Plos One}. PUBLIC LIBRARY SCIENCE: SAN FRANCISCO, roč.~8, č.~12, s.~e81829, 7 s. ISSN~1932-6203. doi:10.1371/journal.pone.0081829. 2013.
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