Transgelins, cytoskeletal proteins implicated in different
aspects of cancer development

J 2014

Transgelins, cytoskeletal proteins implicated in different aspects of cancer development

DVOŘÁKOVÁ, Monika; Rudolf NENUTIL a Pavel BOUCHAL

Základní údaje

Originální název

Transgelins, cytoskeletal proteins implicated in different aspects of cancer development

Autoři

DVOŘÁKOVÁ, Monika; Rudolf NENUTIL a Pavel BOUCHAL

Vydání

Expert Review of Proteomics, 2014, 1478-9450

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.896

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/14:00074976

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

cancer; cytoskeleton; differentiation; proliferation; transgelin; transgelin-2

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 4. 2015 21:51, Ing. Andrea Mikešková

Anotace

V originále

Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression. We also overview the recent data on transgelin-2, a sequence homolog of transgelin, whose role in the tumor development might be contradictory to the role of transgelin.

Citovat

DVOŘÁKOVÁ, Monika; Rudolf NENUTIL a Pavel BOUCHAL. Transgelins, cytoskeletal proteins implicated in different aspects of cancer development. Expert Review of Proteomics. 2014, roč. 11, č. 2, s. 149-165. ISSN 1478-9450. Dostupné z: https://doi.org/10.1586/14789450.2014.860358.

@article{1161769,
   author = {Dvořáková, Monika and Nenutil, Rudolf and Bouchal, Pavel},
   article_number = {2},
   doi = {https://doi.org/10.1586/14789450.2014.860358},
   keywords = {cancer; cytoskeleton; differentiation; proliferation; transgelin; transgelin-2},
   language = {eng},
   issn = {1478-9450},
   journal = {Expert Review of Proteomics},
   title = {Transgelins, cytoskeletal proteins implicated in different aspects of cancer development},
   url = {http://informahealthcare.com/eprint/I4U2ckBV3ZiYpzSHXbJi/full},
   volume = {11},
   year = {2014}
}

TY  - JOUR
ID  - 1161769
AU  - Dvořáková, Monika - Nenutil, Rudolf - Bouchal, Pavel
PY  - 2014
TI  - Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
JF  - Expert Review of Proteomics
VL  - 11
IS  - 2
SP  - 149-165
EP  - 149-165
SN  - 14789450
KW  - cancer
KW  - cytoskeleton
KW  - differentiation
KW  - proliferation
KW  - transgelin
KW  - transgelin-2
UR  - http://informahealthcare.com/eprint/I4U2ckBV3ZiYpzSHXbJi/full
N2  - Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression. We also overview the recent data on transgelin-2, a sequence homolog of transgelin, whose role in the tumor development might be contradictory to the role of transgelin.
ER  -

DVOŘÁKOVÁ, Monika; Rudolf NENUTIL a Pavel BOUCHAL. Transgelins, cytoskeletal proteins implicated in different aspects of cancer development. \textit{Expert Review of Proteomics}. 2014, roč.~11, č.~2, s.~149-165. ISSN~1478-9450. Dostupné z: https://doi.org/10.1586/14789450.2014.860358.

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