Proteomics in investigation of cancer metastasis: Functional
and clinical consequences and methodological challenges.

J 2014

Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.

MARYÁŠ, Josef; Jakub FAKTOR; Monika DVOŘÁKOVÁ; Iva STRUHÁROVÁ; Peter GRELL et al.

Základní údaje

Originální název

Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.

Autoři

MARYÁŠ, Josef; Jakub FAKTOR; Monika DVOŘÁKOVÁ; Iva STRUHÁROVÁ; Peter GRELL a Pavel BOUCHAL

Vydání

Proteomics, Wiley VCH, 2014, 1615-9853

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.807

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/14:00074977

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Biomarkers; Biomedicine; Functional studies; Metastasis; Surface proteins

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 4. 2015 11:08, Ing. Andrea Mikešková

Anotace

V originále

Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade. It is evident that ongoing technical progress will further increase proteome coverage and sample capacity of proteomics technologies, giving complex answers to clinical and functional questions asked.

Návaznosti

MUNI/A/0773/2012, interní kód MU

Název: Podpora biochemického výzkumu

Investor: Masarykova univerzita, Podpora biochemického výzkumu, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

MARYÁŠ, Josef; Jakub FAKTOR; Monika DVOŘÁKOVÁ; Iva STRUHÁROVÁ; Peter GRELL a Pavel BOUCHAL. Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. Proteomics. Wiley VCH, 2014, roč. 14, 4-5, s. 426-440. ISSN 1615-9853. Dostupné z: https://doi.org/10.1002/pmic.201300264.

@article{1161779,
   author = {Maryáš, Josef and Faktor, Jakub and Dvořáková, Monika and Struhárová, Iva and Grell, Peter and Bouchal, Pavel},
   article_number = {4-5},
   doi = {https://doi.org/10.1002/pmic.201300264},
   keywords = {Biomarkers; Biomedicine; Functional studies; Metastasis; Surface proteins},
   language = {eng},
   issn = {1615-9853},
   journal = {Proteomics},
   title = {Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract},
   volume = {14},
   year = {2014}
}

TY  - JOUR
ID  - 1161779
AU  - Maryáš, Josef - Faktor, Jakub - Dvořáková, Monika - Struhárová, Iva - Grell, Peter - Bouchal, Pavel
PY  - 2014
TI  - Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.
JF  - Proteomics
VL  - 14
IS  - 4-5
SP  - 426-440
EP  - 426-440
PB  - Wiley VCH
SN  - 16159853
KW  - Biomarkers
KW  - Biomedicine
KW  - Functional studies
KW  - Metastasis
KW  - Surface proteins
UR  - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract
L2  - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract
N2  - Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade. It is evident that ongoing technical progress will further increase proteome coverage and sample capacity of proteomics technologies, giving complex answers to clinical and functional questions asked.
ER  -

MARYÁŠ, Josef; Jakub FAKTOR; Monika DVOŘÁKOVÁ; Iva STRUHÁROVÁ; Peter GRELL a Pavel BOUCHAL. Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. \textit{Proteomics}. Wiley VCH, 2014, roč.~14, 4-5, s.~426-440. ISSN~1615-9853. Dostupné z: https://doi.org/10.1002/pmic.201300264.

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