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@article{1163395,
author = {Mica, L. and Keller, C. and Vomela, Jindřich and Trentz, O. and Plecko, M. and Keel, M.J.},
article_location = {Munich},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s00068-013-0300-8},
keywords = {body mass index; gender; polytrauma; infection; ISS},
language = {eng},
issn = {1863-9933},
journal = {European Journal of Trauma and Emergency Surgery},
title = {The impact of body mass index and gender on the development of infectious complications in polytrauma patients},
volume = {40},
year = {2014}
}
TY - JOUR
ID - 1163395
AU - Mica, L. - Keller, C. - Vomela, Jindřich - Trentz, O. - Plecko, M. - Keel, M.J.
PY - 2014
TI - The impact of body mass index and gender on the development of infectious complications in polytrauma patients
JF - European Journal of Trauma and Emergency Surgery
VL - 40
IS - 5
SP - 573-579
EP - 573-579
PB - Urban & Vogel
SN - 18639933
KW - body mass index
KW - gender
KW - polytrauma
KW - infection
KW - ISS
N2 - Purpose The aim was to test the impact of body mass index (BMI) and gender on infectious complications after polytrauma. Methods: A total of 651 patients were included in this retrospective study, with an Injury Severity Score (ISS) >= 16 and age >= 16 years. The sample was subdivided into three groups: BMI <25 kg/m(2), BMI 25-30 kg/m(2), and BMI >30 kg/m(2), and a female and a male group. Infectious complications were observed for 31 days after admission. Data are given as mean +/- standard errors of the means. Analysis of variance, Kruskal-Wallis test, chi(2) tests, and Pearson's correlation were used for the analyses and the significance level was set at P < 0.05. Results: The overall infection rates were 31.0 % in the BMI < 25 kg/m(2) group, 29.0 % in the BMI 25-30 kg/m(2) group, and 24.5 % in the BMI > 30 kg/m(2) group (P = 0.519). The female patients developed significantly fewer infectious complications than the male patients (26.8 vs. 73.2 %; P < 0.001). The incidence of death was significantly decreased according to the BMI group (8.8 vs. 7.2 vs. 1.5 %; P < 0.0001) and the female population had a significantly lower mortality rate (4.1 vs. 13.4 %; P < 0.0001). Pearson's correlations between the Abbreviated Injury Scale (AIS) score and the corresponding infectious foci were not significant. Conclusion: Higher BMI seems to be protective against polytrauma-associated death but not polytrauma-associated infections, and female gender protects against both polytrauma-associated infections and death. Understanding gender-specific immunomodulation could improve the outcome of polytrauma patients.
ER -
MICA, L., C. KELLER, Jindřich VOMELA, O. TRENTZ, M. PLECKO a M.J. KEEL. The impact of body mass index and gender on the development of infectious complications in polytrauma patients. \textit{European Journal of Trauma and Emergency Surgery}. Munich: Urban \&{} Vogel, 2014, roč.~40, č.~5, s.~573-579. ISSN~1863-9933. Dostupné z: https://dx.doi.org/10.1007/s00068-013-0300-8.
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