Interactive effect of MTHFR and ADRA2A gene polymorphisms on
pathogenesis of schizophrenia

J 2013

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia

LOCHMAN, Jan; Jiří PLESNÍK; Vladimír JANOUT; Jana POVOVÁ; Ivan MÍŠEK et al.

Základní údaje

Originální název

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia

Autoři

LOCHMAN, Jan; Jiří PLESNÍK; Vladimír JANOUT; Jana POVOVÁ; Ivan MÍŠEK; Dagmar DVOŘÁKOVÁ a Omar ŠERÝ

Vydání

Neuroendocrinology Letters, Edition Medizin, 2013, 0172-780X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Lucembursko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.935

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/13:00071796

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000331786100010

Klíčová slova anglicky

MTHFR; COMT; ADRA2A; schizophrenia; association; polymorphism

Štítky

AKR, rivok

Změněno: 28. 4. 2014 15:35, Ing. Andrea Mikešková

Anotace

V originále

Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. Methods: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR 677 CT + TT genotype was found (OR=1.6, P=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met and ADRA2A C-1291G polymorphisms previously associated with schizophrenia risk using a logistic regression analysis. Results: Previous studies of MTHFR*COMT (C677T*Val158Met) interaction in relation to schizophrenia resulted in inconsistent results. In our sample this interaction did not significantly differ between schizophrenics and control subjects. On the other hand analysis of MTHFR*ADRA2A (C677T*C-1291G) interaction revealed significant association between ADRA2A CC+CG genotype in the MTHFR TC+TT carriers (P=0.008). Conclusions: Our results support role of noradrenergic functions as well as previously proposed role of epigenetic control in the pathogenesis of schizophrenia. Further relevant studies including larger sample size and more markers are needed to prove our results.

Citovat

LOCHMAN, Jan; Jiří PLESNÍK; Vladimír JANOUT; Jana POVOVÁ; Ivan MÍŠEK; Dagmar DVOŘÁKOVÁ a Omar ŠERÝ. Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia. Neuroendocrinology Letters. Edition Medizin, 2013, roč. 34, č. 8, s. 792-797. ISSN 0172-780X.

@article{1163550,
   author = {Lochman, Jan and Plesník, Jiří and Janout, Vladimír and Povová, Jana and Míšek, Ivan and Dvořáková, Dagmar and Šerý, Omar},
   article_number = {8},
   keywords = {MTHFR; COMT; ADRA2A; schizophrenia; association; polymorphism},
   language = {eng},
   issn = {0172-780X},
   journal = {Neuroendocrinology Letters},
   title = {Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia},
   volume = {34},
   year = {2013}
}

TY  - JOUR
ID  - 1163550
AU  - Lochman, Jan - Plesník, Jiří - Janout, Vladimír - Povová, Jana - Míšek, Ivan - Dvořáková, Dagmar - Šerý, Omar
PY  - 2013
TI  - Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia
JF  - Neuroendocrinology Letters
VL  - 34
IS  - 8
SP  - 792-797
EP  - 792-797
PB  - Edition Medizin
SN  - 0172780X
KW  - MTHFR
KW  - COMT
KW  - ADRA2A
KW  - schizophrenia
KW  - association
KW  - polymorphism
N2  - Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. Methods: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR 677 CT + TT genotype was found (OR=1.6, P=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met and ADRA2A C-1291G polymorphisms previously associated with schizophrenia risk using a logistic regression analysis. Results: Previous studies of MTHFR*COMT (C677T*Val158Met) interaction in relation to schizophrenia resulted in inconsistent results. In our sample this interaction did not significantly differ between schizophrenics and control subjects. On the other hand analysis of MTHFR*ADRA2A (C677T*C-1291G) interaction revealed significant association between ADRA2A CC+CG genotype in the MTHFR TC+TT carriers (P=0.008). Conclusions: Our results support role of noradrenergic functions as well as previously proposed role of epigenetic control in the pathogenesis of schizophrenia. Further relevant studies including larger sample size and more markers are needed to prove our results.
ER  -

LOCHMAN, Jan; Jiří PLESNÍK; Vladimír JANOUT; Jana POVOVÁ; Ivan MÍŠEK; Dagmar DVOŘÁKOVÁ a Omar ŠERÝ. Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia. \textit{Neuroendocrinology Letters}. Edition Medizin, 2013, roč.~34, č.~8, s.~792-797. ISSN~0172-780X.

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