CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID
ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE
PROGRESSION

a 2013

CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION

NĚMEC, Petr; Jolana LIPKOVÁ; Nikolas PÁVEK; Gatterova JINDRA; Miroslav SOUČEK et al.

Základní údaje

Originální název

CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION

Název česky

Cytokiny v cirkulaci a revmatoidní faktory: IL-15 jako jeden z prognostických faktorů popisujících progresi onemocnění

Autoři

NĚMEC, Petr; Jolana LIPKOVÁ ; Nikolas PÁVEK; Gatterova JINDRA; Miroslav SOUČEK; Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ

Vydání

Annual European Congress of Rheumatology EULAR 2013, 2013

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

UT WoS

000331587904432

Klíčová slova česky

cytokiny, revmatoidní artritida, interleukiny, IL-15

Klíčová slova anglicky

cytokines, rheumatoid arthritis, interleukins, IL-15

Příznaky

Mezinárodní význam

Změněno: 26. 2. 2014 14:04, Mgr. Jolana Lipková, Ph.D.

Anotace

V originále

The progression of rheumatoid arthritis (RA) is strongly associated with the immune mechanisms and substances affecting the immune system including chemokines and cytokines.The aim of the study was to examine the relation among polymorphisms and serum levels of selected cytokines (IL-6, IL-13, IL-15), production of autoantibodies, and factors describing activity and progression of RA, such as DAS28 and Total Sharp score. A total of 144 RA patients according to the ACR classification criteria 1987, and 50 control subjects were recruited into the study. The measurements of serum levels of CRP, ACPA, and RFs, radiographs of both hands with calculation of Total Sharp score (TSS), DAS28, and serum levels of cytokines (IL-6, IL-13, IL-15) were obtained from all RA patients. Significant difference in allele frequencies between RA patients and controls was observed for IL-15 -267C/T polymorphism. No significant association of IL-15 gene polymorphisms (367 G/A, 14035 A/T), IL-13 (-1112 C/T), and IL-6 with RA was found. Significant difference between RA patients and controls was observed for IL-15 -267C/T polymorphism in allele frequencies (p = 0.05). Higher prevalence of heterozygote variants of IL-15 14035 A/T and - 267C/T polymorphisms in the RFs negative subgroup (IgG, IgA, IgM; p < 0.05) were observed. The frequency of the T allele of the IL-13 polymorphism C1112T was higher in subgroup with faster progression of the disease (TSS/month 0.1, p = 0.03). In conclusion, we present a correlation of IL-15 gen promoter polymorphisms with the rheumatoid factor subtypes (RF IgG, IgA, IgM) underlined by association with increased levels in circulation.

Citovat

NĚMEC, Petr; Jolana LIPKOVÁ; Nikolas PÁVEK; Gatterova JINDRA; Miroslav SOUČEK; Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION. In Annual European Congress of Rheumatology EULAR 2013. 2013.

@proceedings{1167115,
   author = {Němec, Petr and Lipková, Jolana and Pávek, Nikolas and Jindra, Gatterova and Souček, Miroslav and Vašků, Anna and Pávková Goldbergová, Monika},
   booktitle = {Annual European Congress of Rheumatology EULAR 2013},
   keywords = {cytokines, rheumatoid arthritis, interleukins, IL-15},
   language = {eng},
   title = {CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION},
   year = {2013}
}

TY  - CONF
ID  - 1167115
AU  - Němec, Petr - Lipková, Jolana - Pávek, Nikolas - Jindra, Gatterova - Souček, Miroslav - Vašků, Anna - Pávková Goldbergová, Monika
PY  - 2013
TI  - CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION
KW  - cytokines, rheumatoid arthritis, interleukins, IL-15
N2  - The progression of rheumatoid arthritis (RA) is strongly associated with the immune mechanisms and substances affecting the immune system including chemokines and cytokines.The aim of the study was to examine the relation among polymorphisms and serum levels of selected cytokines (IL-6, IL-13, IL-15), production of autoantibodies, and factors describing activity and progression of RA, such as DAS28 and Total Sharp score. A total of 144 RA patients according to the ACR classification criteria 1987, and 50 control subjects were recruited into the study. The measurements of serum levels of CRP, ACPA, and RFs, radiographs of both hands with calculation of Total Sharp score (TSS), DAS28, and serum levels of cytokines (IL-6, IL-13, IL-15) were obtained from all RA patients. Significant difference in allele frequencies between RA patients and controls was observed for IL-15 -267C/T polymorphism. No significant association of IL-15 gene polymorphisms (367 G/A, 14035 A/T), IL-13 (-1112 C/T), and IL-6 with RA was found. Significant difference between RA patients and controls was observed for IL-15 -267C/T polymorphism in allele frequencies (p = 0.05). Higher prevalence of heterozygote variants of IL-15 14035 A/T and - 267C/T polymorphisms in the RFs negative subgroup (IgG, IgA, IgM; p < 0.05) were observed. The frequency of the T allele of the IL-13 polymorphism C1112T was higher in subgroup with faster progression of the disease (TSS/month 0.1, p = 0.03). In conclusion, we present a correlation of IL-15 gen promoter polymorphisms with the rheumatoid factor subtypes (RF IgG, IgA, IgM) underlined by association with increased levels in circulation.
ER  -

NĚMEC, Petr; Jolana LIPKOVÁ; Nikolas PÁVEK; Gatterova JINDRA; Miroslav SOUČEK; Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. CIRCULATING CYTOKINE PATTERN AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS:IL-15 AS ONE OF THE PROGNOSTIC FACTOR OF THE DISEASE PROGRESSION. In \textit{Annual European Congress of Rheumatology EULAR 2013}. 2013.

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