Umbilication Is a Strong Predictor of High-Grade Cervical
Intraepithelial Neoplasia

J 2013

Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia

SLAMA, Jiri; Karolina ADAMCOVA; Ladislav DUŠEK; Ondrej SOSNA; David CIBULA et al.

Základní údaje

Originální název

Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia

Autoři

SLAMA, Jiri; Karolina ADAMCOVA; Ladislav DUŠEK; Ondrej SOSNA a David CIBULA

Vydání

JOURNAL OF LOWER GENITAL TRACT DISEASE, PHILADELPHIA, LIPPINCOTT WILLIAMS & WILKINS, 2013, 1089-2591

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.110

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00072524

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1097/LGT.0b013e31826f2532

UT WoS

000330368500011

Klíčová slova anglicky

CIN; colposcopy; ridge sign; umbilication; mosaic

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 4. 2014 15:38, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objective. This study aimed to assess the diagnostic value of the colposcopic feature of umbilication for detecting high-grade cervical intraepithelial neoplasia (CIN 2/3). Materials and Methods. Study included 430 randomly selected women who underwent conization for CIN 2 or CIN 3. The control group consisted of 102 patients with biopsy-confirmed CIN 1. Colpophotographs and reports from colposcopy examinations from all patients were retrospectively analyzed by 2 independent colposcopy experts with the aim to assess the presence of umbilication. The occurence of more than 2 mosaic "tiles" with central punctation was considered to be a positive finding regardless of whether the mosaic pattern was coarse or fine. The prevalence of umbilication in CIN 1 and CIN 2/3 respectively was compared. The diagnostic value of umbilication alone and combination of umbilication and/or ridge sign was assessed. Results. Umbilication was detected in 10% and ridge sign in 10.2% of patients with CIN 2/3. Simultaneous presence of umbilication and ridge sign was rare (1.1%). The umbilication solely reached 12% sensitivity, 100% specificity, and 100% positive predictive value for the detection of underlying CIN 2/3. Conclusions. Umbilication is an age-independent colposcopic feature with very high specificity for predicting CIN 2/3.

Citovat

SLAMA, Jiri; Karolina ADAMCOVA; Ladislav DUŠEK; Ondrej SOSNA a David CIBULA. Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia. JOURNAL OF LOWER GENITAL TRACT DISEASE. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, 2013, roč. 17, č. 3, s. 303-307. ISSN 1089-2591. Dostupné z: https://doi.org/10.1097/LGT.0b013e31826f2532.

@article{1168535,
   author = {Slama, Jiri and Adamcova, Karolina and Dušek, Ladislav and Sosna, Ondrej and Cibula, David},
   article_location = {PHILADELPHIA},
   article_number = {3},
   doi = {https://doi.org/10.1097/LGT.0b013e31826f2532},
   keywords = {CIN; colposcopy; ridge sign; umbilication; mosaic},
   language = {eng},
   issn = {1089-2591},
   journal = {JOURNAL OF LOWER GENITAL TRACT DISEASE},
   title = {Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia},
   volume = {17},
   year = {2013}
}

TY  - JOUR
ID  - 1168535
AU  - Slama, Jiri - Adamcova, Karolina - Dušek, Ladislav - Sosna, Ondrej - Cibula, David
PY  - 2013
TI  - Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia
JF  - JOURNAL OF LOWER GENITAL TRACT DISEASE
VL  - 17
IS  - 3
SP  - 303-307
EP  - 303-307
PB  - LIPPINCOTT WILLIAMS & WILKINS
SN  - 10892591
KW  - CIN
KW  - colposcopy
KW  - ridge sign
KW  - umbilication
KW  - mosaic
N2  - Objective. This study aimed to assess the diagnostic value of the colposcopic feature of umbilication for detecting high-grade cervical intraepithelial neoplasia (CIN 2/3). Materials and Methods. Study included 430 randomly selected women who underwent conization for CIN 2 or CIN 3. The control group consisted of 102 patients with biopsy-confirmed CIN 1. Colpophotographs and reports from colposcopy examinations from all patients were retrospectively analyzed by 2 independent colposcopy experts with the aim to assess the presence of umbilication. The occurence of more than 2 mosaic "tiles" with central punctation was considered to be a positive finding regardless of whether the mosaic pattern was coarse or fine. The prevalence of umbilication in CIN 1 and CIN 2/3 respectively was compared. The diagnostic value of umbilication alone and combination of umbilication and/or ridge sign was assessed. Results. Umbilication was detected in 10% and ridge sign in 10.2% of patients with CIN 2/3. Simultaneous presence of umbilication and ridge sign was rare (1.1%). The umbilication solely reached 12% sensitivity, 100% specificity, and 100% positive predictive value for the detection of underlying CIN 2/3. Conclusions. Umbilication is an age-independent colposcopic feature with very high specificity for predicting CIN 2/3.
ER  -

SLAMA, Jiri; Karolina ADAMCOVA; Ladislav DUŠEK; Ondrej SOSNA a David CIBULA. Umbilication Is a Strong Predictor of High-Grade Cervical Intraepithelial Neoplasia. \textit{JOURNAL OF LOWER GENITAL TRACT DISEASE}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2013, roč.~17, č.~3, s.~303-307. ISSN~1089-2591. Dostupné z: https://doi.org/10.1097/LGT.0b013e31826f2532.

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