STANÍK, Michal, Ivo ČAPÁK, Daniel MACÍK, Jiří VAŠINA, Eva LŽIČAŘOVÁ, Jiří JARKOVSKÝ, Martin ŠUSTR, David MIKLÁNEK a Jan DOLEŽEL. Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer. International Urology and Nephrology. Dordrecht: Springer, 2014, roč. 46, č. 8, s. 1543-1549. ISSN 0301-1623. Dostupné z: https://dx.doi.org/10.1007/s11255-014-0704-3. |
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@article{1173304, author = {Staník, Michal and Čapák, Ivo and Macík, Daniel and Vašina, Jiří and Lžičařová, Eva and Jarkovský, Jiří and Šustr, Martin and Miklánek, David and Doležel, Jan}, article_location = {Dordrecht}, article_number = {8}, doi = {http://dx.doi.org/10.1007/s11255-014-0704-3}, keywords = {Prostatic neoplasms; Lymph node excision; Sentinel lymph node biopsy; Cancer staging}, language = {eng}, issn = {0301-1623}, journal = {International Urology and Nephrology}, title = {Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer}, volume = {46}, year = {2014} }
TY - JOUR ID - 1173304 AU - Staník, Michal - Čapák, Ivo - Macík, Daniel - Vašina, Jiří - Lžičařová, Eva - Jarkovský, Jiří - Šustr, Martin - Miklánek, David - Doležel, Jan PY - 2014 TI - Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer JF - International Urology and Nephrology VL - 46 IS - 8 SP - 1543-1549 EP - 1543-1549 PB - Springer SN - 03011623 KW - Prostatic neoplasms KW - Lymph node excision KW - Sentinel lymph node biopsy KW - Cancer staging N2 - To evaluate benefits of sentinel lymph node (SLN) biopsy for staging accuracy in prostate cancer. Extended pelvic lymph node dissection (ePLND) is a preferred staging tool; however, it may underestimate the incidence of nodal involvement. Eighty patients with estimated risk of lymphadenopathy above 5 % based on Briganti nomogram had Tc-99m-labeled nanocolloid injected into the prostate. Planar lymphoscintigraphy and single-photon emission computed tomography/CT were performed to localize SLNs. Radioguided SLN dissection was followed by backup ePLND comprising external iliac, obturator and internal iliac regions. All SLNs were serially sectioned every 150 mu m and examined using hematoxylin and eosin; immunohistochemical staining was applied every 300 mu m. A total of 335 SLNs were detected, and 17 % were located outside ePLND template. Nodal metastases were diagnosed in 32 patients (40 %). Without radioguided SLN localization, solitary metastases posteriorly to the branches of the internal ilaic vessels, in pararectal and common iliac regions would not have been removed in five of 32 patients (16 %). Using standard histology protocol, we would have diagnosed metastases in 23 patients with median size of 2.8 mm. Serial sectioning of SLN and immunohistochemistry led to the detection of metastases in additional nine patients (28 %) with median size of 0.2 mm. ePLND comprised 83 % of SLNs, at least one SLN laid outside its template in 28 % of patients. ePLND and SLN dissection combined with nodal serial sectioning and immunohistochemistry increased the detection rate of nodal metastases by 68 % in comparison with ePLND alone and standard histology protocol. ER -
STANÍK, Michal, Ivo ČAPÁK, Daniel MACÍK, Jiří VAŠINA, Eva LŽIČAŘOVÁ, Jiří JARKOVSKÝ, Martin ŠUSTR, David MIKLÁNEK a Jan DOLEŽEL. Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer. \textit{International Urology and Nephrology}. Dordrecht: Springer, 2014, roč.~46, č.~8, s.~1543-1549. ISSN~0301-1623. Dostupné z: https://dx.doi.org/10.1007/s11255-014-0704-3.
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