Multiple gene-to-gene interactions in children with sepsis: a
combination of five gene variants predicts outcome of
life-threatening sepsis

J 2014

Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

JABANDŽIEV, Petr; Michal SMEREK; Jaroslav Sr. MICHALEK; Michal FEDORA; Lucie KOŠINOVÁ et al.

Základní údaje

Originální název

Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

Autoři

JABANDŽIEV, Petr; Michal SMEREK; Jaroslav Sr. MICHALEK; Michal FEDORA; Lucie KOŠINOVÁ; Jaroslav A. HUBACEK a Jaroslav MICHÁLEK

Vydání

Critical Care, LONDON, BioMed Central, 2014, 1466-609X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00080126

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

sepsis; children; gene; single nucleotide polymorphism

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 9. 2014 15:09, Soňa Böhmová

Anotace

V originále

Introduction: The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. Methods: We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups. Results: Detailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis. Conclusions: Analysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.

Návaznosti

NS9894, projekt VaV

Název: Role SIRS, NO a oxidativního stresu v rozvoji šokového stavu a mitochondriální dysfunkce jako podklad multiorgánového selhání

Investor: Ministerstvo zdravotnictví ČR, Role SIRS, NO a oxidativního stresu v rozvoji šokového stavu a mitochondriální dysfunkce jako podklad multiorgánového selhání

Citovat

JABANDŽIEV, Petr; Michal SMEREK; Jaroslav Sr. MICHALEK; Michal FEDORA; Lucie KOŠINOVÁ; Jaroslav A. HUBACEK a Jaroslav MICHÁLEK. Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. Critical Care. LONDON: BioMed Central, 2014, roč. 18, č. 1, s. 1-9. ISSN 1466-609X. Dostupné z: https://doi.org/10.1186/cc13174.

@article{1173452,
   author = {Jabandžiev, Petr and Smerek, Michal and Michalek, Jaroslav Sr. and Fedora, Michal and Košinová, Lucie and Hubacek, Jaroslav A. and Michálek, Jaroslav},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1186/cc13174},
   keywords = {sepsis; children; gene; single nucleotide polymorphism},
   language = {eng},
   issn = {1466-609X},
   journal = {Critical Care},
   title = {Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis},
   url = {http://ccforum.com/content/pdf/cc13174.pdf},
   volume = {18},
   year = {2014}
}

TY  - JOUR
ID  - 1173452
AU  - Jabandžiev, Petr - Smerek, Michal - Michalek, Jaroslav Sr. - Fedora, Michal - Košinová, Lucie - Hubacek, Jaroslav A. - Michálek, Jaroslav
PY  - 2014
TI  - Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis
JF  - Critical Care
VL  - 18
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - BioMed Central
SN  - 1466609X
KW  - sepsis
KW  - children
KW  - gene
KW  - single nucleotide polymorphism
UR  - http://ccforum.com/content/pdf/cc13174.pdf
N2  - Introduction: The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. Methods: We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups. Results: Detailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis. Conclusions: Analysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.
ER  -

JABANDŽIEV, Petr; Michal SMEREK; Jaroslav Sr. MICHALEK; Michal FEDORA; Lucie KOŠINOVÁ; Jaroslav A. HUBACEK a Jaroslav MICHÁLEK. Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. \textit{Critical Care}. LONDON: BioMed Central, 2014, roč.~18, č.~1, s.~1-9. ISSN~1466-609X. Dostupné z: https://doi.org/10.1186/cc13174.

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