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@article{1173756,
author = {Uher, Tomas and Bob, Petr},
article_location = {Clare},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.neulet.2012.09.003},
keywords = {Depression; Anxiety; S100B protein; NSE; Cerebrospinal fluid},
language = {eng},
issn = {0304-3940},
journal = {Neuroscience Letters},
title = {Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders},
volume = {529},
year = {2012}
}
TY - JOUR
ID - 1173756
AU - Uher, Tomas - Bob, Petr
PY - 2012
TI - Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders
JF - Neuroscience Letters
VL - 529
IS - 2
SP - 139-143
EP - 139-143
PB - Elsevier
SN - 03043940
KW - Depression
KW - Anxiety
KW - S100B protein
KW - NSE
KW - Cerebrospinal fluid
N2 - Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II). anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p < 0.0009) but not with SAS and TAS-20. The finding indicates that decreased level of Si COB in CSF is related to increased symptoms of depression in the NIND patients. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
ER -
UHER, Tomas a Petr BOB. Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders. \textit{Neuroscience Letters}. Clare: Elsevier, 2012, roč.~529, č.~2, s.~139-143. ISSN~0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2012.09.003.
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