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@article{1173831,
author = {Soldano, Alessia and Okray, Zeynep and Janovská, Pavlína and Tmejová, Kateřina and Reynaud, Elodie and Claeys, Annelies and Yan, Jiekun and Atak, Zeynep Kalender and De Strooper, Bart and Dura, JeanandMaurice and Bryja, Vítězslav and Hassan, Bassem A.},
article_number = {11(5)},
doi = {http://dx.doi.org/10.1371/journal.pbio.1001562},
keywords = {PLANAR CELL POLARITY; ALZHEIMERS-DISEASE; AXONAL-TRANSPORT; FAMILY-MEMBERS; DEFICIENT MICE; GENE; APP; HYPOTHESIS; NEURON; THERAPEUTICS},
language = {eng},
issn = {1544-9173},
journal = {PLoS Biology},
title = {The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.},
url = {http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=X1Amd9VvQGafBKx7B2c&page=1&doc=1},
volume = {2013},
year = {2013}
}
TY - JOUR
ID - 1173831
AU - Soldano, Alessia - Okray, Zeynep - Janovská, Pavlína - Tmejová, Kateřina - Reynaud, Elodie - Claeys, Annelies - Yan, Jiekun - Atak, Zeynep Kalender - De Strooper, Bart - Dura, Jean-Maurice - Bryja, Vítězslav - Hassan, Bassem A.
PY - 2013
TI - The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.
JF - PLoS Biology
VL - 2013
IS - 11(5)
SP - e1001562
EP - e1001562
SN - 15449173
KW - PLANAR CELL POLARITY
KW - ALZHEIMERS-DISEASE
KW - AXONAL-TRANSPORT
KW - FAMILY-MEMBERS
KW - DEFICIENT MICE
KW - GENE
KW - APP
KW - HYPOTHESIS
KW - NEURON
KW - THERAPEUTICS
UR - http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=X1Amd9VvQGafBKx7B2c&page=1&doc=1
N2 - Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) are intensely investigated because of their link to Alzheimer's disease (AD). APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. Drosophila possesses a single APP homologue called APP Like, or APPL. APPL is expressed in all neurons throughout development, but has no established function in neuronal development. We therefore investigated the role of Drosophila APPL during brain development. We find that APPL is involved in the development of the Mushroom Body alfa beta neurons and, in particular, is required cell-autonomously for the beta-axons and non-cell autonomously for the alfa-axons growth. Moreover, we find that APPL is a modulator of the Wnt-PCP pathway required for axonal outgrowth, but not cell polarity. Molecularly, both human APP and fly APPL form complexes with PCP receptors, thus suggesting that APPs are part of the membrane protein complex upstream of PCP signaling. Moreover, we show that APPL regulates PCP pathway activation by modulating the phosphorylation of the Wnt adaptor protein Dishevelled (Dsh) by Abelson kinase (Abl). Taken together our data suggest that APPL is the first example of a modulator of the Wnt-PCP pathway specifically required for axon outgrowth.
ER -
SOLDANO, Alessia, Zeynep OKRAY, Pavlína JANOVSKÁ, Kateřina TMEJOVÁ, Elodie REYNAUD, Annelies CLAEYS, Jiekun YAN, Zeynep Kalender ATAK, Bart DE STROOPER, Jean-Maurice DURA, Vítězslav BRYJA a Bassem A. HASSAN. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. \textit{PLoS Biology}. 2013, roč.~2013, 11(5), s.~e1001562, 13 s. ISSN~1544-9173. Dostupné z: https://dx.doi.org/10.1371/journal.pbio.1001562.
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