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@article{1173919,
author = {Seitz, Katharina and Duersch, Verena and Harnoš, Jakub and Bryja, Vítězslav and Gentzel, Marc and Schambony, Alexandra},
article_number = {1},
doi = {http://dx.doi.org/10.1371/journal.pone.0087132},
keywords = {CONVERGENT EXTENSION MOVEMENTS; WNT SIGNALING PATHWAYS; WNT/BETA-CATENIN; VERTEBRATE GASTRULATION; PARAXIAL PROTOCADHERIN; TISSUE SEPARATION; ACTIVATION; FRIZZLED-7; LAEVIS; KINASE},
language = {eng},
issn = {1932-6203},
journal = {PLOS ONE},
title = {beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation},
url = {http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=17&SID=R2g9W8Fv71CDiX3zjH6&page=1&doc=1#},
volume = {9},
year = {2014}
}
TY - JOUR
ID - 1173919
AU - Seitz, Katharina - Duersch, Verena - Harnoš, Jakub - Bryja, Vítězslav - Gentzel, Marc - Schambony, Alexandra
PY - 2014
TI - beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation
JF - PLOS ONE
VL - 9
IS - 1
SP - "nestrankovano"
EP - "nestrankovano"
SN - 19326203
KW - CONVERGENT EXTENSION MOVEMENTS
KW - WNT SIGNALING PATHWAYS
KW - WNT/BETA-CATENIN
KW - VERTEBRATE GASTRULATION
KW - PARAXIAL PROTOCADHERIN
KW - TISSUE SEPARATION
KW - ACTIVATION
KW - FRIZZLED-7
KW - LAEVIS
KW - KINASE
UR - http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=17&SID=R2g9W8Fv71CDiX3zjH6&page=1&doc=1#
N2 - beta-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and beta-Catenin independent signaling cascades including the Wnt/Planar Cell Polarity and the Wnt/Ca2+ cascades. Wnt/Planar Cell Polarity and Wnt/Ca2+ pathways share common effector proteins, including the Wnt ligand, Frizzled receptors and Dishevelled, with each other and with additional branches of Wnt signaling. Along with the aforementioned proteins, beta-Arrestin has been identified as an essential effector protein in the Wnt/beta-Catenin and the Wnt/Planar Cell Polarity pathway. Our results demonstrate that beta-Arrestin is required in the Wnt/Ca2+ signaling cascade upstream of Protein Kinase C (PKC) and Ca2+/Calmodulin-dependent Protein Kinase II (CamKII). We have further characterized the role of beta-Arrestin in this branch of non-canonical Wnt signaling by knock-down and rescue experiments in Xenopus embryo explants and analyzed protein-protein interactions in 293T cells. Functional interaction of beta-Arrestin, the beta subunit of trimeric G-proteins and Dishevelled is required to induce PKC activation and membrane translocation. In Xenopus gastrulation, beta-Arrestin function in Wnt/Ca2+ signaling is essential for convergent extension movements. We further show that beta-Arrestin physically interacts with the beta subunit of trimeric G-proteins and Dishevelled, and that the interaction between beta-Arrestin and Dishevelled is promoted by the beta/gamma subunits of trimeric G-proteins, indicating the formation of a multiprotein signaling complex.
ER -
SEITZ, Katharina, Verena DUERSCH, Jakub HARNOŠ, Vítězslav BRYJA, Marc GENTZEL a Alexandra SCHAMBONY. beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation. \textit{PLOS ONE}. 2014, roč.~9, č.~1, s.~''nestrankovano'', 11 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0087132.
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