Heterogeneity and Plasticity of Multiple Myeloma

C 2013

Heterogeneity and Plasticity of Multiple Myeloma

ŠVÁCHOVÁ, Hana; Sabina ŠEVČÍKOVÁ a Roman HÁJEK

Základní údaje

Originální název

Heterogeneity and Plasticity of Multiple Myeloma

Autoři

ŠVÁCHOVÁ, Hana; Sabina ŠEVČÍKOVÁ a Roman HÁJEK

Vydání

Rijeka, Multiple Myeloma - A Quick Reflection on the Fast Progress, od s. 61-91, 31 s. 2013

Nakladatel

InTech

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Chorvatsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00067049

Organizační jednotka

Lékařská fakulta

ISBN

978-953-51-1083-5

Klíčová slova anglicky

Multiple Myeloma

Změněno: 3. 4. 2014 12:32, Soňa Böhmová

Anotace

V originále

Modern molecular and cytogenetic approaches have furthered progress in our understanding of MM biology and have led to the development of targeted therapy that has improved management of this incurable disease. Novel agents such as bortezomib, lenalidomide or thalidomide, have increased median survival rates and improved prospects for MM patients resistant to conventional therapy [1, 2]. Despite these therapeutic advances, MM remains a very difficult disease to treat still accompanied by the threat of repeated relapses with a fatal ending. These observations indicate that at least some of the MM cells are not targeted efficiently by current drug therapies. The existence of such persistent populations, called myeloma stem cells (MSC) or myeloma-initiating cells (MIC) has been suspected for more than two decades. However, the cells of origin remain elusive [3-9]. Timeline of growing knowledge about putative MSC is displayed in Figure 1. Discrepancies among myeloma stem cell concepts have arisen in parallel with the high phenotypic heterogeneity of clonal PCs that might be another factor contributing to the failure of therapies and identification of the population responsible for relapse. Myeloma PCs strongly depends on the supportive role of the bone marrow (BM) microenvironment (MEV) – it is a source of essential growth factors, supports survival and dissemination of pathological PCs [10-14]. Furthermore, hypoxic conditions of tumor microenvironments support tumor progression by inducing angiogenesis, maintaining the malignant phenotype and stimulating osteoclastogenesis [15-18]. There is growing evidence that signals from pathological microenvironments can (reversibly) alter the phenotype of PCs. Such plasticity of PCs might result in obvious heterogeneity of MM and generate inconsistencies among myeloma stem cell concepts.

Návaznosti

GAP304/10/1395, projekt VaV

Název: Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií

Investor: Grantová agentura ČR, Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií

MSM0021622434, záměr

Název: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií

Citovat

ŠVÁCHOVÁ, Hana; Sabina ŠEVČÍKOVÁ a Roman HÁJEK. Heterogeneity and Plasticity of Multiple Myeloma. Online. In Roman Hajek. Multiple Myeloma - A Quick Reflection on the Fast Progress. Rijeka: InTech, 2013, s. 61-91. ISBN 978-953-51-1083-5.

@inbook{1174085,
   author = {Šváchová, Hana and Ševčíková, Sabina and Hájek, Roman},
   address = {Rijeka},
   booktitle = {Multiple Myeloma - A Quick Reflection on the Fast Progress},
   editor = {Roman Hajek},
   keywords = {Multiple Myeloma},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Rijeka},
   isbn = {978-953-51-1083-5},
   pages = {61-91},
   publisher = {InTech},
   title = {Heterogeneity and Plasticity of Multiple Myeloma},
   year = {2013}
}

TY  - CHAP
ID  - 1174085
AU  - Šváchová, Hana - Ševčíková, Sabina - Hájek, Roman
PY  - 2013
TI  - Heterogeneity and Plasticity of Multiple Myeloma
VL  - Neuveden
PB  - InTech
CY  - Rijeka
SN  - 9789535110835
KW  - Multiple Myeloma
N2  - Modern molecular and cytogenetic approaches have furthered progress in our understanding of MM biology and have led to the development of targeted therapy that has improved management of this incurable disease. Novel agents such as bortezomib, lenalidomide or thalidomide, have increased median survival rates and improved prospects for MM patients resistant to conventional therapy [1, 2]. Despite these therapeutic advances, MM remains a very difficult disease to treat still accompanied by the threat of repeated relapses with a fatal ending. These observations indicate that at least some of the MM cells are not targeted efficiently by current drug therapies. The existence of such persistent populations, called myeloma stem cells (MSC) or myeloma-initiating cells (MIC) has been suspected for more than two decades. However, the cells of origin remain elusive [3-9]. Timeline of growing knowledge about putative MSC is displayed in Figure 1. Discrepancies among myeloma stem cell concepts have arisen in parallel with the high phenotypic heterogeneity of clonal PCs that might be another factor contributing to the failure of therapies and identification of the population responsible for relapse. Myeloma PCs strongly depends on the supportive role of the bone marrow (BM) microenvironment (MEV) – it is a source of essential growth factors, supports survival and dissemination of pathological PCs [10-14]. Furthermore, hypoxic conditions of tumor microenvironments support tumor progression by inducing angiogenesis, maintaining the malignant phenotype and stimulating osteoclastogenesis [15-18]. There is growing evidence that signals from pathological microenvironments can (reversibly) alter the phenotype of PCs. Such plasticity of PCs might result in obvious heterogeneity of MM and generate inconsistencies among myeloma stem cell concepts.
ER  -

ŠVÁCHOVÁ, Hana; Sabina ŠEVČÍKOVÁ a Roman HÁJEK. Heterogeneity and Plasticity of Multiple Myeloma. Online. In Roman Hajek. \textit{Multiple Myeloma - A Quick Reflection on the Fast Progress}. Rijeka: InTech, 2013, s.~61-91. ISBN~978-953-51-1083-5.

Přehled o publikaci