| ESCHER, B., M. ALLINSON, R. ALTENBURGER, P.A. BAIN, P. BALAGUER, W. BUSCH, J. CRAGO, N.D. DENSLOW, E. DOPP, Klára HILSCHEROVÁ, A.R. HUMPAGE, A. KUMAR, M. GRIMALDI, B.S. JAYASINGHE, Barbora JAROŠOVÁ, A. JIA, S. MAKAROV, K.A. MARUYA, A. MEDVEDEV, A.C. MEHINTO, J.E. MENDEZ, A. POULSEN, E. PROCHAZKA, J. RICHARD, A. SCHIFFERLI, D. SCHLENK, S. SCHOLZ, F. SHIRAISH, S. SNYDER, G.Y. SU, J.Y.M. TANG, B. VAN DER BURG, S.C. VAN DER LINDEN, I. WERNER, S.D. WESTERHEIDE, C.K.C. WONG, M. YANG, B.H.Y. YEUNG, X.W. ZHANG a F.D.L. LEUSCH. Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays. ENVIRONMENTAL SCIENCE &TECHNOLOGY. WASHINGTON: AMER CHEMICAL SOC, 2014, roč. 48, č. 3, s. 1940-1956. ISSN 0013-936X. Dostupné z: https://dx.doi.org/10.1021/es403899t. |
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@article{1174144,
author = {Escher, B. and Allinson, M. and Altenburger, R. and Bain, P.A. and Balaguer, P. and Busch, W. and Crago, J. and Denslow, N.D. and Dopp, E. and Hilscherová, Klára and Humpage, A.R. and Kumar, A. and Grimaldi, M. and Jayasinghe, B.S. and Jarošová, Barbora and Jia, A. and Makarov, S. and Maruya, K.A. and Medvedev, A. and Mehinto, A.C. and Mendez, J.E. and Poulsen, A. and Prochazka, E. and Richard, J. and Schifferli, A. and Schlenk, D. and Scholz, S. and Shiraish, F. and Snyder, S. and Su, G.Y. and Tang, J.Y.M. and van der Burg, B. and van der Linden, S.C. and Werner, I. and Westerheide, S.D. and Wong, C.K.C. and Yang, M. and Yeung, B.H.Y. and Zhang, X.W. and Leusch, F.D.L.},
article_location = {WASHINGTON},
article_number = {3},
doi = {http://dx.doi.org/10.1021/es403899t},
keywords = {REPORTER CELL-LINES; ACTIVATED CARBON FILTRATION; ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS-RESPONSE; DISINFECTION BY-PRODUCTS; QUALITY TRIGGER VALUES; EPAS TOXCAST PROGRAM; BIOANALYTICAL TOOLS; ENVIRONMENTAL-POLLUTANTS; REPRODUCTIVE TOXICANTS},
language = {eng},
issn = {0013-936X},
journal = {ENVIRONMENTAL SCIENCE &TECHNOLOGY},
title = {Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays},
volume = {48},
year = {2014}
}
TY - JOUR
ID - 1174144
AU - Escher, B. - Allinson, M. - Altenburger, R. - Bain, P.A. - Balaguer, P. - Busch, W. - Crago, J. - Denslow, N.D. - Dopp, E. - Hilscherová, Klára - Humpage, A.R. - Kumar, A. - Grimaldi, M. - Jayasinghe, B.S. - Jarošová, Barbora - Jia, A. - Makarov, S. - Maruya, K.A. - Medvedev, A. - Mehinto, A.C. - Mendez, J.E. - Poulsen, A. - Prochazka, E. - Richard, J. - Schifferli, A. - Schlenk, D. - Scholz, S. - Shiraish, F. - Snyder, S. - Su, G.Y. - Tang, J.Y.M. - van der Burg, B. - van der Linden, S.C. - Werner, I. - Westerheide, S.D. - Wong, C.K.C. - Yang, M. - Yeung, B.H.Y. - Zhang, X.W. - Leusch, F.D.L.
PY - 2014
TI - Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays
JF - ENVIRONMENTAL SCIENCE &TECHNOLOGY
VL - 48
IS - 3
SP - 1940-1956
EP - 1940-1956
PB - AMER CHEMICAL SOC
SN - 0013936X
KW - REPORTER CELL-LINES
KW - ACTIVATED CARBON FILTRATION
KW - ARYL-HYDROCARBON RECEPTOR
KW - OXIDATIVE STRESS-RESPONSE
KW - DISINFECTION BY-PRODUCTS
KW - QUALITY TRIGGER VALUES
KW - EPAS TOXCAST PROGRAM
KW - BIOANALYTICAL TOOLS
KW - ENVIRONMENTAL-POLLUTANTS
KW - REPRODUCTIVE TOXICANTS
N2 - Thousands of organic micropollutants and their transformation products occur in water. Although often present at low concentrations, individual compounds contribute to mixture effects. Cell-based bioassays that target health-relevant biological endpoints may therefore complement chemical analysis for water quality assessment. The objective of this study was to evaluate cell-based bioassays for their suitability to benchmark water quality and to assess efficacy of water treatment processes. The selected bioassays cover relevant steps in the toxicity pathways including induction of xenobiotic metabolism, specific and reactive modes of toxic action, activation of adaptive stress response pathways and system responses. Twenty laboratories applied 103 unique in vitro bioassays to a common set of 10 water samples collected in Australia, including wastewater treatment plant effluent, two types of recycled water (reverse osmosis and ozonation/activated carbon filtration), stormwater, surface water, and drinking water. Sixty-five bioassays (63%) showed positive results in at least one sample, typically in wastewater treatment plant effluent, and only five (5%) were positive in the control (ultrapure water). Each water type had a characteristic bioanalytical profile with particular groups of toxicity pathways either consistently responsive or not responsive across test systems. The most responsive health-relevant endpoints were related to xenobiotic metabolism (pregnane X and aryl hydrocarbon receptors), hormone-mediated modes of action (mainly related to the estrogen, glucocorticoid, and antiandrogen activities), reactive modes of action (genotoxicity) and adaptive stress response pathway (oxidative stress response). This study has demonstrated that selected cell-based bioassays are suitable to benchmark water quality and it is recommended to use a purpose-tailored panel of bioassays for routine monitoring.
ER -
ESCHER, B., M. ALLINSON, R. ALTENBURGER, P.A. BAIN, P. BALAGUER, W. BUSCH, J. CRAGO, N.D. DENSLOW, E. DOPP, Klára HILSCHEROVÁ, A.R. HUMPAGE, A. KUMAR, M. GRIMALDI, B.S. JAYASINGHE, Barbora JAROŠOVÁ, A. JIA, S. MAKAROV, K.A. MARUYA, A. MEDVEDEV, A.C. MEHINTO, J.E. MENDEZ, A. POULSEN, E. PROCHAZKA, J. RICHARD, A. SCHIFFERLI, D. SCHLENK, S. SCHOLZ, F. SHIRAISH, S. SNYDER, G.Y. SU, J.Y.M. TANG, B. VAN DER BURG, S.C. VAN DER LINDEN, I. WERNER, S.D. WESTERHEIDE, C.K.C. WONG, M. YANG, B.H.Y. YEUNG, X.W. ZHANG a F.D.L. LEUSCH. Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays. \textit{ENVIRONMENTAL SCIENCE \&{}TECHNOLOGY}. WASHINGTON: AMER CHEMICAL SOC, 2014, roč.~48, č.~3, s.~1940-1956. ISSN~0013-936X. Dostupné z: https://dx.doi.org/10.1021/es403899t.
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