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@article{1180440,
author = {Hoffmannová, Jiřina and Foltán, René and Vlk, Marek and Šipoš, Michal and Horká, Edita and Pavlíková, Gabriela and Kufa, Roman and Bulik, Oliver and Šedý, Jiří},
article_location = {EDINBURGH, Scotland},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.ijom.2010.03.010},
keywords = {squamous cell carcinoma; oral cavity; retrospective study; tumour; actinotherapy; hemimandibulectomy; neck dissection},
language = {eng},
issn = {0901-5027},
journal = {International Journal of Oral and Maxillofacial Surgery},
title = {Hemimandibulectomy and therapeutic neck dissection with radiotherapy in the treatment of oral squamous cell carcinoma involving mandible: a critical review of treatment protocol in the years 1994-2004},
volume = {39},
year = {2010}
}
TY - JOUR
ID - 1180440
AU - Hoffmannová, Jiřina - Foltán, René - Vlk, Marek - Šipoš, Michal - Horká, Edita - Pavlíková, Gabriela - Kufa, Roman - Bulik, Oliver - Šedý, Jiří
PY - 2010
TI - Hemimandibulectomy and therapeutic neck dissection with radiotherapy in the treatment of oral squamous cell carcinoma involving mandible: a critical review of treatment protocol in the years 1994-2004
JF - International Journal of Oral and Maxillofacial Surgery
VL - 39
IS - 6
SP - 561-567
EP - 561-567
PB - CHURCHILL LIVINGSTONE
SN - 09015027
KW - squamous cell carcinoma
KW - oral cavity
KW - retrospective study
KW - tumour
KW - actinotherapy
KW - hemimandibulectomy
KW - neck dissection
N2 - This retrospective non-randomized 10-year follow-up study compared 147 patients with squamous cell carcinoma (SCC) of the oral cavity requiring hemimandibulectomy, treated by surgical resection, therapeutic neck dissection and radiotherapy The 5-year survival rates were compared related to localization, size of the tumour, infiltration of locoregional lymph nodes, distant metastases, histopathological grading, radicality of surgery, and invasion of tumour into the mandible Occurrence of tumour relapse and its localization was studied The mean 5-year survival rate was 26% Patients with SCC of the mandibular alveolar process had higher rates, the lowest rates occurred in SCC of the buccal mucosa. Survival rate was significantly lower with insufficient resection of the tumour (85% relapse) An important number of patients with radical resection died within 3 months of surgery In almost 55% of the mandibles turnout was not present In 5% of infiltrated mandibles, dissemination into inferior alveolar nerve was proven Decreasing survival rate was seen with increasing size of tumour and higher histological grade Therapeutic neck dissection significantly reduces survival rate and increases the percentage of lymph node relapse. Elective neck dissection should be performed in SCC requiring hemimandibulectomy Primary reconstruction should reverse the high percentage of postoperative complication arising from increased radicality
ER -
HOFFMANNOVÁ, Jiřina, René FOLTÁN, Marek VLK, Michal ŠIPOŠ, Edita HORKÁ, Gabriela PAVLÍKOVÁ, Roman KUFA, Oliver BULIK a Jiří ŠEDÝ. Hemimandibulectomy and therapeutic neck dissection with radiotherapy in the treatment of oral squamous cell carcinoma involving mandible: a critical review of treatment protocol in the years 1994-2004. \textit{International Journal of Oral and Maxillofacial Surgery}. EDINBURGH, Scotland: CHURCHILL LIVINGSTONE, roč.~39, č.~6, s.~561-567. ISSN~0901-5027. doi:10.1016/j.ijom.2010.03.010. 2010.
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