Dendritic cells and their role in tumor immunosurveillance

J 2013

Dendritic cells and their role in tumor immunosurveillance

STRIOGA, Marius; Virgil SCHIJNS; Daniel J Jr POWELL; Vita PASUKONIENE; Neringa DOBROVOLSKIENE et al.

Základní údaje

Originální název

Dendritic cells and their role in tumor immunosurveillance

Autoři

STRIOGA, Marius; Virgil SCHIJNS; Daniel J Jr POWELL; Vita PASUKONIENE; Neringa DOBROVOLSKIENE a Jaroslav MICHÁLEK

Vydání

Journal of Innate Immunity, 2013, 1753-4259

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.459

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/13:00065766

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1177/1753425912449549

UT WoS

000313592100010

Klíčová slova anglicky

Dendritic cell biology; immunogenic and tolerogenic dendritic cells; killer dendritic cells; tumor immunosurveillance; immunosuppression; vascular leukocytes

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 4. 2014 13:57, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Dendritic cells (DCs) comprise a heterogeneous population of cells that play a key role in initiating, directing and regulating adaptive immune responses, including those critically involved in tumor immunosurveillance. As a riposte to the central role of DCs in the generation of antitumor immune responses, tumors have developed various mechanisms which impair the immunostimulatory functions of DCs or even instruct them to actively contribute to tumor growth and progression. In the first part of this review we discuss general aspects of DC biology, including their origin, subtypes, immature and mature states, and functional plasticity which ensures a delicate balance between active immune response and immune tolerance. In the second part of the review we discuss the complex interactions between DCs and the tumor microenvironment, and point out the challenges faced by DCs during the recognition of tumor Ags. We also discuss the role of DCs in tumor angiogenesis and vasculogenesis.

Návaznosti

NT11137, projekt VaV

Název: Protinádorová terapie - vakcinace dendritickými buňkami u pacientů s metastázujícím renálním karcinomem. Klinická studie fáze II.

Investor: Ministerstvo zdravotnictví ČR, Protinádorová terapie - vakcinace dendritickými buňkami u pacientů s metastázujícím renálním karcinomem. Klinická studie fáze II.

Citovat

STRIOGA, Marius; Virgil SCHIJNS; Daniel J Jr POWELL; Vita PASUKONIENE; Neringa DOBROVOLSKIENE a Jaroslav MICHÁLEK. Dendritic cells and their role in tumor immunosurveillance. Journal of Innate Immunity. 2013, roč. 19, č. 1, s. 98-111. ISSN 1753-4259. Dostupné z: https://doi.org/10.1177/1753425912449549.

@article{1180965,
   author = {Strioga, Marius and Schijns, Virgil and Powell, Daniel J Jr and Pasukoniene, Vita and Dobrovolskiene, Neringa and Michálek, Jaroslav},
   article_number = {1},
   doi = {https://doi.org/10.1177/1753425912449549},
   keywords = {Dendritic cell biology; immunogenic and tolerogenic dendritic cells; killer dendritic cells; tumor immunosurveillance; immunosuppression; vascular leukocytes},
   language = {eng},
   issn = {1753-4259},
   journal = {Journal of Innate Immunity},
   title = {Dendritic cells and their role in tumor immunosurveillance},
   volume = {19},
   year = {2013}
}

TY  - JOUR
ID  - 1180965
AU  - Strioga, Marius - Schijns, Virgil - Powell, Daniel J Jr - Pasukoniene, Vita - Dobrovolskiene, Neringa - Michálek, Jaroslav
PY  - 2013
TI  - Dendritic cells and their role in tumor immunosurveillance
JF  - Journal of Innate Immunity
VL  - 19
IS  - 1
SP  - 98-111
EP  - 98-111
SN  - 17534259
KW  - Dendritic cell biology
KW  - immunogenic and tolerogenic dendritic cells
KW  - killer dendritic cells
KW  - tumor immunosurveillance
KW  - immunosuppression
KW  - vascular leukocytes
N2  - Dendritic cells (DCs) comprise a heterogeneous population of cells that play a key role in initiating, directing and regulating adaptive immune responses, including those critically involved in tumor immunosurveillance. As a riposte to the central role of DCs in the generation of antitumor immune responses, tumors have developed various mechanisms which impair the immunostimulatory functions of DCs or even instruct them to actively contribute to tumor growth and progression. In the first part of this review we discuss general aspects of DC biology, including their origin, subtypes, immature and mature states, and functional plasticity which ensures a delicate balance between active immune response and immune tolerance. In the second part of the review we discuss the complex interactions between DCs and the tumor microenvironment, and point out the challenges faced by DCs during the recognition of tumor Ags. We also discuss the role of DCs in tumor angiogenesis and vasculogenesis.
ER  -

STRIOGA, Marius; Virgil SCHIJNS; Daniel J Jr POWELL; Vita PASUKONIENE; Neringa DOBROVOLSKIENE a Jaroslav MICHÁLEK. Dendritic cells and their role in tumor immunosurveillance. \textit{Journal of Innate Immunity}. 2013, roč.~19, č.~1, s.~98-111. ISSN~1753-4259. Dostupné z: https://doi.org/10.1177/1753425912449549.

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