Strategies to manage hepatitis C virus (HCV) disease burden
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WEDEMEYER, H.; A. S. DUBERG; M. BUTI; W. M. ROSENBERG; S. FRANKOVA; G. ESMAT; N. ÖRMECI; H. VAN VLIERBERGHE; M. GSCHWANTLER; U. AKARCA; S. ALEMAN; I. BALIK; T. BERG; F. BIHL; M. BILODEAU; A. J. BLASCO; C. E. Brandão MELLO; P. BRUGGMANN; F. CALINAS; J. L. CALLEJA; H. CHEINQUER; P. B. CHRISTENSEN; M. CLAUSEN; H. S. M. COELHO; M. CORNBERG; M. E. CRAMP; G. J. DORE; W. DOSS; M. H. EL-SAYED; G. ERGÖR; C. ESTES; K. FALCONER; J. FÉLIX; M. L. G. FERRAZ; P. R. FERREIRA; J. GARCÍA-SAMANIEGO; J. GERSTOFT; J. A. GIRIA; F. L. Jr. GONÇALES; M. Guimarães PESSÔA; C. HÉZODE; S. J. HINDMAN; H. HOFER; Petr HUSA; R. IDILMAN; M. KÅBERG; K. D. E. KAITA; A. KAUTZ; S. KAYMAKOGLU; M. KRAJDEN; H. KRARUP; W. LALEMAN; D. LAVANCHY; P. LÁZARO; R. T. MARINHO; P. MAROTTA; S. MAUSS; M. C. Mendes CORREA; C. MORENO; B. MÜLLHAUPT; R. P. MYERS; V. NEMECEK; A. L. H. ØVREHUS; J. PARKES; K. M. PELTEKIAN; A. RAMJI; H. RAZAVI; N. REIS; S. K. ROBERTS; F. ROUDOT-THORAVAL; S. D. RYDER; R. SARMENTO-CASTRO; C. SARRAZIN; D. SEMELA; M. SHERMAN; G. E. SHIHA; J. SPERL; P. STÄRKEL; R. E. STAUBER; A. J. THOMPSON; P. URBANEK; P. Van DAMME; I. van THIEL; D. VANDIJCK; W. VOGEL; I. WAKED; N. WEIS; J. WIEGAND; A. YOSRY; A. ZEKRY; F. NEGRO; W. SIEVERT a E. GOWER
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JOURNAL OF VIRAL HEPATITIS, HOBOKEN, WILEY-BLACKWELL, 2014, 1352-0504
The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.
WEDEMEYER, H.; A. S. DUBERG; M. BUTI; W. M. ROSENBERG; S. FRANKOVA; G. ESMAT; N. ÖRMECI; H. VAN VLIERBERGHE; M. GSCHWANTLER; U. AKARCA; S. ALEMAN; I. BALIK; T. BERG; F. BIHL; M. BILODEAU; A. J. BLASCO; C. E. Brandão MELLO; P. BRUGGMANN; F. CALINAS; J. L. CALLEJA; H. CHEINQUER; P. B. CHRISTENSEN; M. CLAUSEN; H. S. M. COELHO; M. CORNBERG; M. E. CRAMP; G. J. DORE; W. DOSS; M. H. EL-SAYED; G. ERGÖR; C. ESTES; K. FALCONER; J. FÉLIX; M. L. G. FERRAZ; P. R. FERREIRA; J. GARCÍA-SAMANIEGO; J. GERSTOFT; J. A. GIRIA; F. L. Jr. GONÇALES; M. Guimarães PESSÔA; C. HÉZODE; S. J. HINDMAN; H. HOFER; Petr HUSA; R. IDILMAN; M. KÅBERG; K. D. E. KAITA; A. KAUTZ; S. KAYMAKOGLU; M. KRAJDEN; H. KRARUP; W. LALEMAN; D. LAVANCHY; P. LÁZARO; R. T. MARINHO; P. MAROTTA; S. MAUSS; M. C. Mendes CORREA; C. MORENO; B. MÜLLHAUPT; R. P. MYERS; V. NEMECEK; A. L. H. ØVREHUS; J. PARKES; K. M. PELTEKIAN; A. RAMJI; H. RAZAVI; N. REIS; S. K. ROBERTS; F. ROUDOT-THORAVAL; S. D. RYDER; R. SARMENTO-CASTRO; C. SARRAZIN; D. SEMELA; M. SHERMAN; G. E. SHIHA; J. SPERL; P. STÄRKEL; R. E. STAUBER; A. J. THOMPSON; P. URBANEK; P. Van DAMME; I. van THIEL; D. VANDIJCK; W. VOGEL; I. WAKED; N. WEIS; J. WIEGAND; A. YOSRY; A. ZEKRY; F. NEGRO; W. SIEVERT a E. GOWER. Strategies to manage hepatitis C virus (HCV) disease burden. JOURNAL OF VIRAL HEPATITIS. HOBOKEN: WILEY-BLACKWELL, 2014, roč. 21, Supplement 1, s. 60-89. ISSN 1352-0504. Dostupné z: https://doi.org/10.1111/jvh.12249.
@article{1182576, author = {Wedemeyer, H. and Duberg, A. S. and Buti, M. and Rosenberg, W. M. and Frankova, S. and Esmat, G. and Örmeci, N. and Van Vlierberghe, H. and Gschwantler, M. and Akarca, U. and Aleman, S. and Balik, I. and Berg, T. and Bihl, F. and Bilodeau, M. and Blasco, A. J. and Mello, C. E. Brandão and Bruggmann, P. and Calinas, F. and Calleja, J. L. and Cheinquer, H. and Christensen, P. B. and Clausen, M. and Coelho, H. S. M. and Cornberg, M. and Cramp, M. E. and Dore, G. J. and Doss, W. and ElandSayed, M. H. and Ergör, G. and Estes, C. and Falconer, K. and Félix, J. and Ferraz, M. L. G. and Ferreira, P. R. and GarcíaandSamaniego, J. and Gerstoft, J. and Giria, J. A. and Gonçales, F. L. Jr. and Pessôa, M. Guimarães and Hézode, C. and Hindman, S. J. and Hofer, H. and Husa, Petr and Idilman, R. and Kåberg, M. and Kaita, K. D. E. and Kautz, A. and Kaymakoglu, S. and Krajden, M. and Krarup, H. and Laleman, W. and Lavanchy, D. and Lázaro, P. and Marinho, R. T. and Marotta, P. and Mauss, S. and Correa, M. C. Mendes and Moreno, C. and Müllhaupt, B. and Myers, R. P. and Nemecek, V. and Øvrehus, A. L. H. and Parkes, J. and Peltekian, K. M. and Ramji, A. and Razavi, H. and Reis, N. and Roberts, S. K. and RoudotandThoraval, F. and Ryder, S. D. and SarmentoandCastro, R. and Sarrazin, C. and Semela, D. and Sherman, M. and Shiha, G. E. and Sperl, J. and Stärkel, P. and Stauber, R. E. and Thompson, A. J. and Urbanek, P. and Damme, P. Van and Thiel, I. van and Vandijck, D. and Vogel, W. and Waked, I. and Weis, N. and Wiegand, J. and Yosry, A. and Zekry, A. and Negro, F. and Sievert, W. and Gower, E.}, article_location = {HOBOKEN}, article_number = {Supplement 1}, doi = {https://doi.org/10.1111/jvh.12249}, keywords = {diagnosis; epidemiology; HCV; mortality; treatment; scenarios; prevalence; incidence; hepatitis C; disease burden}, language = {eng}, issn = {1352-0504}, journal = {JOURNAL OF VIRAL HEPATITIS}, title = {Strategies to manage hepatitis C virus (HCV) disease burden}, volume = {21}, year = {2014} }
TY - JOUR ID - 1182576 AU - Wedemeyer, H. - Duberg, A. S. - Buti, M. - Rosenberg, W. M. - Frankova, S. - Esmat, G. - Örmeci, N. - Van Vlierberghe, H. - Gschwantler, M. - Akarca, U. - Aleman, S. - Balik, I. - Berg, T. - Bihl, F. - Bilodeau, M. - Blasco, A. J. - Mello, C. E. Brandão - Bruggmann, P. - Calinas, F. - Calleja, J. L. - Cheinquer, H. - Christensen, P. B. - Clausen, M. - Coelho, H. S. M. - Cornberg, M. - Cramp, M. E. - Dore, G. J. - Doss, W. - El-Sayed, M. H. - Ergör, G. - Estes, C. - Falconer, K. - Félix, J. - Ferraz, M. L. G. - Ferreira, P. R. - García-Samaniego, J. - Gerstoft, J. - Giria, J. A. - Gonçales, F. L. Jr. - Pessôa, M. Guimarães - Hézode, C. - Hindman, S. J. - Hofer, H. - Husa, Petr - Idilman, R. - Kåberg, M. - Kaita, K. D. E. - Kautz, A. - Kaymakoglu, S. - Krajden, M. - Krarup, H. - Laleman, W. - Lavanchy, D. - Lázaro, P. - Marinho, R. T. - Marotta, P. - Mauss, S. - Correa, M. C. Mendes - Moreno, C. - Müllhaupt, B. - Myers, R. P. - Nemecek, V. - Øvrehus, A. L. H. - Parkes, J. - Peltekian, K. M. - Ramji, A. - Razavi, H. - Reis, N. - Roberts, S. K. - Roudot-Thoraval, F. - Ryder, S. D. - Sarmento-Castro, R. - Sarrazin, C. - Semela, D. - Sherman, M. - Shiha, G. E. - Sperl, J. - Stärkel, P. - Stauber, R. E. - Thompson, A. J. - Urbanek, P. - Damme, P. Van - Thiel, I. van - Vandijck, D. - Vogel, W. - Waked, I. - Weis, N. - Wiegand, J. - Yosry, A. - Zekry, A. - Negro, F. - Sievert, W. - Gower, E. PY - 2014 TI - Strategies to manage hepatitis C virus (HCV) disease burden JF - JOURNAL OF VIRAL HEPATITIS VL - 21 IS - Supplement 1 SP - 60-89 EP - 60-89 PB - WILEY-BLACKWELL SN - 13520504 KW - diagnosis KW - epidemiology KW - HCV KW - mortality KW - treatment KW - scenarios KW - prevalence KW - incidence KW - hepatitis C KW - disease burden N2 - The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical. ER -
WEDEMEYER, H.; A. S. DUBERG; M. BUTI; W. M. ROSENBERG; S. FRANKOVA; G. ESMAT; N. ÖRMECI; H. VAN VLIERBERGHE; M. GSCHWANTLER; U. AKARCA; S. ALEMAN; I. BALIK; T. BERG; F. BIHL; M. BILODEAU; A. J. BLASCO; C. E. Brandão MELLO; P. BRUGGMANN; F. CALINAS; J. L. CALLEJA; H. CHEINQUER; P. B. CHRISTENSEN; M. CLAUSEN; H. S. M. COELHO; M. CORNBERG; M. E. CRAMP; G. J. DORE; W. DOSS; M. H. EL-SAYED; G. ERGÖR; C. ESTES; K. FALCONER; J. FÉLIX; M. L. G. FERRAZ; P. R. FERREIRA; J. GARCÍA-SAMANIEGO; J. GERSTOFT; J. A. GIRIA; F. L. Jr. GON$\backslash$C CALES; M. Guimarães PESSÔA; C. HÉZODE; S. J. HINDMAN; H. HOFER; Petr HUSA; R. IDILMAN; M. KÅBERG; K. D. E. KAITA; A. KAUTZ; S. KAYMAKOGLU; M. KRAJDEN; H. KRARUP; W. LALEMAN; D. LAVANCHY; P. LÁZARO; R. T. MARINHO; P. MAROTTA; S. MAUSS; M. C. Mendes CORREA; C. MORENO; B. MÜLLHAUPT; R. P. MYERS; V. NEMECEK; A. L. H. ØVREHUS; J. PARKES; K. M. PELTEKIAN; A. RAMJI; H. RAZAVI; N. REIS; S. K. ROBERTS; F. ROUDOT-THORAVAL; S. D. RYDER; R. SARMENTO-CASTRO; C. SARRAZIN; D. SEMELA; M. SHERMAN; G. E. SHIHA; J. SPERL; P. STÄRKEL; R. E. STAUBER; A. J. THOMPSON; P. URBANEK; P. Van DAMME; I. van THIEL; D. VANDIJCK; W. VOGEL; I. WAKED; N. WEIS; J. WIEGAND; A. YOSRY; A. ZEKRY; F. NEGRO; W. SIEVERT a E. GOWER. Strategies to manage hepatitis C virus (HCV) disease burden. \textit{JOURNAL OF VIRAL HEPATITIS}. HOBOKEN: WILEY-BLACKWELL, 2014, roč.~21, Supplement 1, s.~60-89. ISSN~1352-0504. Dostupné z: https://doi.org/10.1111/jvh.12249.