The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
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RAZAVI, H.; I. WAKED; C. SARRAZIN; R. P. MYERS; R. IDILMAN; F. CALINAS; W. VOGEL; M. C. Mendes CORREA; C. HÉZODE; P. LÁZARO; U. AKARCA; S. ALEMAN; I. BALIK; T. BERG; F. BIHL; M. BILODEAU; A. J. BLASCO; C. E. Brandão MELLO; P. BRUGGMANN; M. BUTI; J. L. CALLEJA; H. CHEINQUER; P. B. CHRISTENSEN; M. CLAUSEN; H. S. M. COELHO; M. E. CRAMP; G. J. DORE; W. DOSS; A. S. DUBERG; M. H. EL-SAYED; G. ERGÖR; G. ESMAT; K. FALCONER; J. FÉLIX; M. L. G. FERRAZ; P. R. FERREIRA; S. FRANKOVA; J. GARCÍA-SAMANIEGO; J. GERSTOFT; J. A. GIRIA; F. L. Jr. GONÇALES; E. GOWER; M. GSCHWANTLER; M. Guimarães PESSÔA; S. J. HINDMAN; H. HOFER; Petr HUSA; M. KÅBERG; K. D. E. KAITA; A. KAUTZ; S. KAYMAKOGLU; M. KRAJDEN; H. KRARUP; W. LALEMAN; D. LAVANCHY; R. T. MARINHO; P. MAROTTA; S. MAUSS; C. MORENO; K. MURPHY; F. NEGRO; V. NEMECEK; N. ÖRMECI; A. L. H. ØVREHUS; J. PARKES; K. PASINI; K. M. PELTEKIAN; A. RAMJI; N. REIS; S. K. ROBERTS; W. M. ROSENBERG; F. ROUDOT-THORAVAL; S. D. RYDER; R. SARMENTO-CASTRO; D. SEMELA; M. SHERMAN; G. E. SHIHA; W. SIEVERT; J. SPERL; P. STÄRKEL; R. E. STAUBER; A. J. THOMPSON; P. URBANEK; P. Van DAMME; I. van THIEL; H. Van VLIERBERGHE; D. VANDIJCK; H. WEDEMEYER; N. WEIS; J. WIEGAND; A. YOSRY; A. ZEKRY; M. CORNBERG; B. MÜLLHAUPT a C. ESTES
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JOURNAL OF VIRAL HEPATITIS, HOBOKEN, WILEY-BLACKWELL, 2014, 1352-0504
The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.
RAZAVI, H.; I. WAKED; C. SARRAZIN; R. P. MYERS; R. IDILMAN; F. CALINAS; W. VOGEL; M. C. Mendes CORREA; C. HÉZODE; P. LÁZARO; U. AKARCA; S. ALEMAN; I. BALIK; T. BERG; F. BIHL; M. BILODEAU; A. J. BLASCO; C. E. Brandão MELLO; P. BRUGGMANN; M. BUTI; J. L. CALLEJA; H. CHEINQUER; P. B. CHRISTENSEN; M. CLAUSEN; H. S. M. COELHO; M. E. CRAMP; G. J. DORE; W. DOSS; A. S. DUBERG; M. H. EL-SAYED; G. ERGÖR; G. ESMAT; K. FALCONER; J. FÉLIX; M. L. G. FERRAZ; P. R. FERREIRA; S. FRANKOVA; J. GARCÍA-SAMANIEGO; J. GERSTOFT; J. A. GIRIA; F. L. Jr. GONÇALES; E. GOWER; M. GSCHWANTLER; M. Guimarães PESSÔA; S. J. HINDMAN; H. HOFER; Petr HUSA; M. KÅBERG; K. D. E. KAITA; A. KAUTZ; S. KAYMAKOGLU; M. KRAJDEN; H. KRARUP; W. LALEMAN; D. LAVANCHY; R. T. MARINHO; P. MAROTTA; S. MAUSS; C. MORENO; K. MURPHY; F. NEGRO; V. NEMECEK; N. ÖRMECI; A. L. H. ØVREHUS; J. PARKES; K. PASINI; K. M. PELTEKIAN; A. RAMJI; N. REIS; S. K. ROBERTS; W. M. ROSENBERG; F. ROUDOT-THORAVAL; S. D. RYDER; R. SARMENTO-CASTRO; D. SEMELA; M. SHERMAN; G. E. SHIHA; W. SIEVERT; J. SPERL; P. STÄRKEL; R. E. STAUBER; A. J. THOMPSON; P. URBANEK; P. Van DAMME; I. van THIEL; H. Van VLIERBERGHE; D. VANDIJCK; H. WEDEMEYER; N. WEIS; J. WIEGAND; A. YOSRY; A. ZEKRY; M. CORNBERG; B. MÜLLHAUPT a C. ESTES. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. JOURNAL OF VIRAL HEPATITIS. HOBOKEN: WILEY-BLACKWELL, 2014, roč. 21, Supplement 1, s. 34-59. ISSN 1352-0504. Dostupné z: https://doi.org/10.1111/jvh.12248.
@article{1182601, author = {Razavi, H. and Waked, I. and Sarrazin, C. and Myers, R. P. and Idilman, R. and Calinas, F. and Vogel, W. and Correa, M. C. Mendes and Hézode, C. and Lázaro, P. and Akarca, U. and Aleman, S. and Balik, I. and Berg, T. and Bihl, F. and Bilodeau, M. and Blasco, A. J. and Mello, C. E. Brandão and Bruggmann, P. and Buti, M. and Calleja, J. L. and Cheinquer, H. and Christensen, P. B. and Clausen, M. and Coelho, H. S. M. and Cramp, M. E. and Dore, G. J. and Doss, W. and Duberg, A. S. and ElandSayed, M. H. and Ergör, G. and Esmat, G. and Falconer, K. and Félix, J. and Ferraz, M. L. G. and Ferreira, P. R. and Frankova, S. and GarcíaandSamaniego, J. and Gerstoft, J. and Giria, J. A. and Gonçales, F. L. Jr. and Gower, E. and Gschwantler, M. and Pessôa, M. Guimarães and Hindman, S. J. and Hofer, H. and Husa, Petr and Kåberg, M. and Kaita, K. D. E. and Kautz, A. and Kaymakoglu, S. and Krajden, M. and Krarup, H. and Laleman, W. and Lavanchy, D. and Marinho, R. T. and Marotta, P. and Mauss, S. and Moreno, C. and Murphy, K. and Negro, F. and Nemecek, V. and Örmeci, N. and Øvrehus, A. L. H. and Parkes, J. and Pasini, K. and Peltekian, K. M. and Ramji, A. and Reis, N. and Roberts, S. K. and Rosenberg, W. M. and RoudotandThoraval, F. and Ryder, S. D. and SarmentoandCastro, R. and Semela, D. and Sherman, M. and Shiha, G. E. and Sievert, W. and Sperl, J. and Stärkel, P. and Stauber, R. E. and Thompson, A. J. and Urbanek, P. and Damme, P. Van and Thiel, I. van and Vlierberghe, H. Van and Vandijck, D. and Wedemeyer, H. and Weis, N. and Wiegand, J. and Yosry, A. and Zekry, A. and Cornberg, M. and Müllhaupt, B. and Estes, C.}, article_location = {HOBOKEN}, article_number = {Supplement 1}, doi = {https://doi.org/10.1111/jvh.12248}, keywords = {HCV; diagnosis; treatment; hepatitis C; prevalence; epidemiology; disease burden; mortality; incidence}, language = {eng}, issn = {1352-0504}, journal = {JOURNAL OF VIRAL HEPATITIS}, title = {The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm}, volume = {21}, year = {2014} }
TY - JOUR ID - 1182601 AU - Razavi, H. - Waked, I. - Sarrazin, C. - Myers, R. P. - Idilman, R. - Calinas, F. - Vogel, W. - Correa, M. C. Mendes - Hézode, C. - Lázaro, P. - Akarca, U. - Aleman, S. - Balik, I. - Berg, T. - Bihl, F. - Bilodeau, M. - Blasco, A. J. - Mello, C. E. Brandão - Bruggmann, P. - Buti, M. - Calleja, J. L. - Cheinquer, H. - Christensen, P. B. - Clausen, M. - Coelho, H. S. M. - Cramp, M. E. - Dore, G. J. - Doss, W. - Duberg, A. S. - El-Sayed, M. H. - Ergör, G. - Esmat, G. - Falconer, K. - Félix, J. - Ferraz, M. L. G. - Ferreira, P. R. - Frankova, S. - García-Samaniego, J. - Gerstoft, J. - Giria, J. A. - Gonçales, F. L. Jr. - Gower, E. - Gschwantler, M. - Pessôa, M. Guimarães - Hindman, S. J. - Hofer, H. - Husa, Petr - Kåberg, M. - Kaita, K. D. E. - Kautz, A. - Kaymakoglu, S. - Krajden, M. - Krarup, H. - Laleman, W. - Lavanchy, D. - Marinho, R. T. - Marotta, P. - Mauss, S. - Moreno, C. - Murphy, K. - Negro, F. - Nemecek, V. - Örmeci, N. - Øvrehus, A. L. H. - Parkes, J. - Pasini, K. - Peltekian, K. M. - Ramji, A. - Reis, N. - Roberts, S. K. - Rosenberg, W. M. - Roudot-Thoraval, F. - Ryder, S. D. - Sarmento-Castro, R. - Semela, D. - Sherman, M. - Shiha, G. E. - Sievert, W. - Sperl, J. - Stärkel, P. - Stauber, R. E. - Thompson, A. J. - Urbanek, P. - Damme, P. Van - Thiel, I. van - Vlierberghe, H. Van - Vandijck, D. - Wedemeyer, H. - Weis, N. - Wiegand, J. - Yosry, A. - Zekry, A. - Cornberg, M. - Müllhaupt, B. - Estes, C. PY - 2014 TI - The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm JF - JOURNAL OF VIRAL HEPATITIS VL - 21 IS - Supplement 1 SP - 34-59 EP - 34-59 PB - WILEY-BLACKWELL SN - 13520504 KW - HCV KW - diagnosis KW - treatment KW - hepatitis C KW - prevalence KW - epidemiology KW - disease burden KW - mortality KW - incidence N2 - The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing. ER -
RAZAVI, H.; I. WAKED; C. SARRAZIN; R. P. MYERS; R. IDILMAN; F. CALINAS; W. VOGEL; M. C. Mendes CORREA; C. HÉZODE; P. LÁZARO; U. AKARCA; S. ALEMAN; I. BALIK; T. BERG; F. BIHL; M. BILODEAU; A. J. BLASCO; C. E. Brandão MELLO; P. BRUGGMANN; M. BUTI; J. L. CALLEJA; H. CHEINQUER; P. B. CHRISTENSEN; M. CLAUSEN; H. S. M. COELHO; M. E. CRAMP; G. J. DORE; W. DOSS; A. S. DUBERG; M. H. EL-SAYED; G. ERGÖR; G. ESMAT; K. FALCONER; J. FÉLIX; M. L. G. FERRAZ; P. R. FERREIRA; S. FRANKOVA; J. GARCÍA-SAMANIEGO; J. GERSTOFT; J. A. GIRIA; F. L. Jr. GON$\backslash$C CALES; E. GOWER; M. GSCHWANTLER; M. Guimarães PESSÔA; S. J. HINDMAN; H. HOFER; Petr HUSA; M. KÅBERG; K. D. E. KAITA; A. KAUTZ; S. KAYMAKOGLU; M. KRAJDEN; H. KRARUP; W. LALEMAN; D. LAVANCHY; R. T. MARINHO; P. MAROTTA; S. MAUSS; C. MORENO; K. MURPHY; F. NEGRO; V. NEMECEK; N. ÖRMECI; A. L. H. ØVREHUS; J. PARKES; K. PASINI; K. M. PELTEKIAN; A. RAMJI; N. REIS; S. K. ROBERTS; W. M. ROSENBERG; F. ROUDOT-THORAVAL; S. D. RYDER; R. SARMENTO-CASTRO; D. SEMELA; M. SHERMAN; G. E. SHIHA; W. SIEVERT; J. SPERL; P. STÄRKEL; R. E. STAUBER; A. J. THOMPSON; P. URBANEK; P. Van DAMME; I. van THIEL; H. Van VLIERBERGHE; D. VANDIJCK; H. WEDEMEYER; N. WEIS; J. WIEGAND; A. YOSRY; A. ZEKRY; M. CORNBERG; B. MÜLLHAUPT a C. ESTES. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. \textit{JOURNAL OF VIRAL HEPATITIS}. HOBOKEN: WILEY-BLACKWELL, 2014, roč.~21, Supplement 1, s.~34-59. ISSN~1352-0504. Dostupné z: https://doi.org/10.1111/jvh.12248.