The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia

SEHNAL, Borek, Ladislav DUŠEK, David CIBULA, Tomas ZIMA, Michael HALASKA, Daniel DRIAK a Jiri SLAMA. The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia. JOURNAL OF CLINICAL VIROLOGY. Amsterdam: ELSEVIER SCIENCE BV, 2014, roč. 59, č. 1, s. 18-23. ISSN 1386-6532. Dostupné z: https://dx.doi.org/10.1016/j.jcv.2013.11.004.

Základní údaje

• Originální název: The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia
• Autoři: SEHNAL, Borek (203 Česká republika), Ladislav DUŠEK (203 Česká republika, garant, domácí), David CIBULA (203 Česká republika), Tomas ZIMA (203 Česká republika), Michael HALASKA (203 Česká republika), Daniel DRIAK (203 Česká republika) a Jiri SLAMA (203 Česká republika).
• Vydání: JOURNAL OF CLINICAL VIROLOGY, Amsterdam, ELSEVIER SCIENCE BV, 2014, 1386-6532.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 10600 1.6 Biological sciences
• Stát vydavatele: Nizozemské království
• Utajení: není předmětem státního či obchodního tajemství
• Impakt faktor: Impact factor: 3.016
• Kód RIV: RIV/00216224:14110/14:00075518
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1016/j.jcv.2013.11.004
• UT WoS: 000329408700004
• Klíčová slova anglicky: HPV; CIN; Cervical infection; Anal infection; Anal cancer
• Štítky: EL OK
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Background: More than 90% of cases of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) is established as possible risk factor. Objectives: To demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer. Study design: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy-confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Cobas and Lynear array HPV test. Results: Cervical, anal, and concurrent cervical and anal HPV infections were detected in 82.6%, 48.3% and 42.4% of women in the study group, and in 28.0%, 26.0% and 8.0% of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections of the cervix and anus occurred 5.3-fold more often in the study group than in the control group. Any contact with the anus was the only significant risk factor for development of concurrent HPV infection. Conclusions: Concurrent anal and cervical HR HPV infection was found in nearly half of women with CIN2+. The dominant genotype found in both anatomical locations was HPV 16. Any frequency and any type of contact with the anus were shown as the most important risk factor for concurrent HPV infection.