The relationship between the cervical and anal HPV infection in
women with cervical intraepithelial neoplasia

J 2014

The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia

SEHNAL, Borek; Ladislav DUŠEK; David CIBULA; Tomas ZIMA; Michael HALASKA et al.

Základní údaje

Originální název

The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia

Autoři

SEHNAL, Borek; Ladislav DUŠEK; David CIBULA; Tomas ZIMA; Michael HALASKA; Daniel DRIAK a Jiri SLAMA

Vydání

JOURNAL OF CLINICAL VIROLOGY, Amsterdam, ELSEVIER SCIENCE BV, 2014, 1386-6532

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.016

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075518

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.jcv.2013.11.004

UT WoS

000329408700004

EID Scopus

2-s2.0-84891818274

Klíčová slova anglicky

HPV; CIN; Cervical infection; Anal infection; Anal cancer

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 5. 2014 17:20, Soňa Böhmová

Anotace

V originále

Background: More than 90% of cases of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) is established as possible risk factor. Objectives: To demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer. Study design: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy-confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Cobas and Lynear array HPV test. Results: Cervical, anal, and concurrent cervical and anal HPV infections were detected in 82.6%, 48.3% and 42.4% of women in the study group, and in 28.0%, 26.0% and 8.0% of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections of the cervix and anus occurred 5.3-fold more often in the study group than in the control group. Any contact with the anus was the only significant risk factor for development of concurrent HPV infection. Conclusions: Concurrent anal and cervical HR HPV infection was found in nearly half of women with CIN2+. The dominant genotype found in both anatomical locations was HPV 16. Any frequency and any type of contact with the anus were shown as the most important risk factor for concurrent HPV infection.

Citovat

SEHNAL, Borek; Ladislav DUŠEK; David CIBULA; Tomas ZIMA; Michael HALASKA; Daniel DRIAK a Jiri SLAMA. The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia. JOURNAL OF CLINICAL VIROLOGY. Amsterdam: ELSEVIER SCIENCE BV, 2014, roč. 59, č. 1, s. 18-23. ISSN 1386-6532. Dostupné z: https://doi.org/10.1016/j.jcv.2013.11.004.

@article{1183210,
   author = {Sehnal, Borek and Dušek, Ladislav and Cibula, David and Zima, Tomas and Halaska, Michael and Driak, Daniel and Slama, Jiri},
   article_location = {Amsterdam},
   article_number = {1},
   doi = {https://doi.org/10.1016/j.jcv.2013.11.004},
   keywords = {HPV; CIN; Cervical infection; Anal infection; Anal cancer},
   language = {eng},
   issn = {1386-6532},
   journal = {JOURNAL OF CLINICAL VIROLOGY},
   title = {The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia},
   volume = {59},
   year = {2014}
}

TY  - JOUR
ID  - 1183210
AU  - Sehnal, Borek - Dušek, Ladislav - Cibula, David - Zima, Tomas - Halaska, Michael - Driak, Daniel - Slama, Jiri
PY  - 2014
TI  - The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia
JF  - JOURNAL OF CLINICAL VIROLOGY
VL  - 59
IS  - 1
SP  - 18-23
EP  - 18-23
PB  - ELSEVIER SCIENCE BV
SN  - 13866532
KW  - HPV
KW  - CIN
KW  - Cervical infection
KW  - Anal infection
KW  - Anal cancer
N2  - Background: More than 90% of cases of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) is established as possible risk factor. Objectives: To demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer. Study design: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy-confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Cobas and Lynear array HPV test. Results: Cervical, anal, and concurrent cervical and anal HPV infections were detected in 82.6%, 48.3% and 42.4% of women in the study group, and in 28.0%, 26.0% and 8.0% of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections of the cervix and anus occurred 5.3-fold more often in the study group than in the control group. Any contact with the anus was the only significant risk factor for development of concurrent HPV infection. Conclusions: Concurrent anal and cervical HR HPV infection was found in nearly half of women with CIN2+. The dominant genotype found in both anatomical locations was HPV 16. Any frequency and any type of contact with the anus were shown as the most important risk factor for concurrent HPV infection.
ER  -

SEHNAL, Borek; Ladislav DUŠEK; David CIBULA; Tomas ZIMA; Michael HALASKA; Daniel DRIAK a Jiri SLAMA. The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia. \textit{JOURNAL OF CLINICAL VIROLOGY}. Amsterdam: ELSEVIER SCIENCE BV, 2014, roč.~59, č.~1, s.~18-23. ISSN~1386-6532. Dostupné z: https://doi.org/10.1016/j.jcv.2013.11.004.

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