ATM and TGFB1 genes polymorphisms in prediction of late
complications of chemoradiotherapy in patients with locally
advanced cervical cancer

J 2014

ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer

PAULIKOVA, S.; J. PETERA; Igor SIRÁK; M. VOSMIK; M. DRASTIKOVA et al.

Základní údaje

Originální název

ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer

Autoři

PAULIKOVA, S.; J. PETERA; Igor SIRÁK; M. VOSMIK; M. DRASTIKOVA; Ladislav DUŠEK; Michaela CVANOVÁ; Renata SOUMAROVÁ; J. SPACEK a M. BERANEK

Vydání

Neoplasma, Bratislava, Slovenská akademie vied, 2014, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.865

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075527

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.4149/neo_2014_010

UT WoS

000329769500010

EID Scopus

2-s2.0-84893199098

Klíčová slova anglicky

cervical cancer; radiotherapy; ATM; TGFB1; late toxicity

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 5. 2014 11:52, Soňa Böhmová

Anotace

V originále

The purpose of our study was to evaluate a possible correlation between genetic polymorphisms in ATM and TGFB1 genes and late toxicity of chemoradiotherapy for locally advanced cervical cancer. Fifty five patients with FIGO stage JIB and higher without a disease recurrence with a mean follow up of 6 years were included. Late toxicity was assessed by EORTC/RTOG late toxicity criteria. Univariate and multivariate logistic regression model was used for statistical analysis. Degree of association between polymorphisms and late toxicity of chemotherapy was assessed on the basis of phi-coefficient (phi) as well. We did not find any association between 5557G>A polymorphism in the ATM gene or single TGFB1 polymorphisms and late toxicity. TGFB1 compound homozygosity (-1552delAGG, -509C>T, L10P) was a significant predictive factor of grade III-IV and any grade of complications in both univariate and multivariate logistic regression analyses and statistical significance of association between polymorphisms and late toxicity of chemoradiotherapy was confirmed also by the evaluation of phi-coefficient (phi). We conclude that haplotypes instead of single nucleotide polymorphic sites in the genes may better characterize the individual radiosensitivity.

Citovat

PAULIKOVA, S.; J. PETERA; Igor SIRÁK; M. VOSMIK; M. DRASTIKOVA; Ladislav DUŠEK; Michaela CVANOVÁ; Renata SOUMAROVÁ; J. SPACEK a M. BERANEK. ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer. Neoplasma. Bratislava: Slovenská akademie vied, 2014, roč. 61, č. 1, s. 70-76. ISSN 0028-2685. Dostupné z: https://doi.org/10.4149/neo_2014_010.

@article{1183272,
   author = {Paulikova, S. and Petera, J. and Sirák, Igor and Vosmik, M. and Drastikova, M. and Dušek, Ladislav and Cvanová, Michaela and Soumarová, Renata and Spacek, J. and Beranek, M.},
   article_location = {Bratislava},
   article_number = {1},
   doi = {https://doi.org/10.4149/neo_2014_010},
   keywords = {cervical cancer; radiotherapy; ATM; TGFB1; late toxicity},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer},
   volume = {61},
   year = {2014}
}

TY  - JOUR
ID  - 1183272
AU  - Paulikova, S. - Petera, J. - Sirák, Igor - Vosmik, M. - Drastikova, M. - Dušek, Ladislav - Cvanová, Michaela - Soumarová, Renata - Spacek, J. - Beranek, M.
PY  - 2014
TI  - ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer
JF  - Neoplasma
VL  - 61
IS  - 1
SP  - 70-76
EP  - 70-76
PB  - Slovenská akademie vied
SN  - 00282685
KW  - cervical cancer
KW  - radiotherapy
KW  - ATM
KW  - TGFB1
KW  - late toxicity
N2  - The purpose of our study was to evaluate a possible correlation between genetic polymorphisms in ATM and TGFB1 genes and late toxicity of chemoradiotherapy for locally advanced cervical cancer. Fifty five patients with FIGO stage JIB and higher without a disease recurrence with a mean follow up of 6 years were included. Late toxicity was assessed by EORTC/RTOG late toxicity criteria. Univariate and multivariate logistic regression model was used for statistical analysis. Degree of association between polymorphisms and late toxicity of chemotherapy was assessed on the basis of phi-coefficient (phi) as well. We did not find any association between 5557G>A polymorphism in the ATM gene or single TGFB1 polymorphisms and late toxicity. TGFB1 compound homozygosity (-1552delAGG, -509C>T, L10P) was a significant predictive factor of grade III-IV and any grade of complications in both univariate and multivariate logistic regression analyses and statistical significance of association between polymorphisms and late toxicity of chemoradiotherapy was confirmed also by the evaluation of phi-coefficient (phi). We conclude that haplotypes instead of single nucleotide polymorphic sites in the genes may better characterize the individual radiosensitivity.
ER  -

PAULIKOVA, S.; J. PETERA; Igor SIRÁK; M. VOSMIK; M. DRASTIKOVA; Ladislav DUŠEK; Michaela CVANOVÁ; Renata SOUMAROVÁ; J. SPACEK a M. BERANEK. ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2014, roč.~61, č.~1, s.~70-76. ISSN~0028-2685. Dostupné z: https://doi.org/10.4149/neo\_{}2014\_{}010.

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