Interaction of Dietary Fatty Acids with Tumour Necrosis Factor
Family Cytokines during Colon Inflammation and Cancer

J 2014

Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer

HOFMANOVÁ, Jiřina, Nicol STRAKOVÁ, Alena HYRŠLOVÁ VACULOVÁ, Zuzana TYLICHOVÁ, Barbora ŠAFAŘÍKOVÁ et. al.

Základní údaje

Originální název

Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer

Autoři

HOFMANOVÁ, Jiřina (203 Česká republika), Nicol STRAKOVÁ (203 Česká republika), Alena HYRŠLOVÁ VACULOVÁ (203 Česká republika), Zuzana TYLICHOVÁ (203 Česká republika, domácí), Barbora ŠAFAŘÍKOVÁ (203 Česká republika, domácí), Belma SKENDER (70 Bosna a Hercegovina) a Alois KOZUBÍK (203 Česká republika, domácí)

Vydání

Mediators of Inflammation, Hindawi Publishing Corporation, 2014, 0962-9351

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.236

Kód RIV

RIV/00216224:14310/14:00082028

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1155/2014/848632

UT WoS

000335742300001

Klíčová slova anglicky

NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; RECEPTOR-MEDIATED APOPTOSIS

Štítky

AKR, rivok

Změněno: 26. 4. 2016 15:58, Ing. Andrea Mikešková

Anotace

V originále

Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies. Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined.

Citovat

HOFMANOVÁ, Jiřina, Nicol STRAKOVÁ, Alena HYRŠLOVÁ VACULOVÁ, Zuzana TYLICHOVÁ, Barbora ŠAFAŘÍKOVÁ, Belma SKENDER a Alois KOZUBÍK. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. Mediators of Inflammation. Hindawi Publishing Corporation, 2014, roč. 2014, č. 2014, s. "nestrankovano", 17 s. ISSN 0962-9351. Dostupné z: https://dx.doi.org/10.1155/2014/848632.

@article{1184670,
   author = {Hofmanová, Jiřina and Straková, Nicol and Hyršlová Vaculová, Alena and Tylichová, Zuzana and Šafaříková, Barbora and Skender, Belma and Kozubík, Alois},
   article_number = {2014},
   doi = {http://dx.doi.org/10.1155/2014/848632},
   keywords = {NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; RECEPTOR-MEDIATED APOPTOSIS},
   language = {eng},
   issn = {0962-9351},
   journal = {Mediators of Inflammation},
   title = {Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer},
   volume = {2014},
   year = {2014}
}

TY  - JOUR
ID  - 1184670
AU  - Hofmanová, Jiřina - Straková, Nicol - Hyršlová Vaculová, Alena - Tylichová, Zuzana - Šafaříková, Barbora - Skender, Belma - Kozubík, Alois
PY  - 2014
TI  - Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
JF  - Mediators of Inflammation
VL  - 2014
IS  - 2014
SP  - "nestrankovano"
EP  - "nestrankovano"
PB  - Hindawi Publishing Corporation
SN  - 09629351
KW  - NF-KAPPA-B
KW  - TRAIL-INDUCED APOPTOSIS
KW  - RECEPTOR-MEDIATED APOPTOSIS
N2  - Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development. We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies. Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined.
ER  -

HOFMANOVÁ, Jiřina, Nicol STRAKOVÁ, Alena HYRŠLOVÁ VACULOVÁ, Zuzana TYLICHOVÁ, Barbora ŠAFAŘÍKOVÁ, Belma SKENDER a Alois KOZUBÍK. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. \textit{Mediators of Inflammation}. Hindawi Publishing Corporation, 2014, roč.~2014, č.~2014, s.~''nestrankovano'', 17 s. ISSN~0962-9351. Dostupné z: https://dx.doi.org/10.1155/2014/848632.

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