Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor
of cyclooxygenase-2, meloxicam, given alone or in a combination
early after total body irradiation enhance survival of
gamma-irradiated mice

J 2014

Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ; Denisa KOMURKOVA et al.

Základní údaje

Originální název

Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice

Autoři

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMURKOVA

Vydání

Radiation and Environmental Biophysics, New York, Springer-Verlag, 2014, 0301-634X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.528

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00073672

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1007/s00411-013-0500-y

UT WoS

000331977300018

EID Scopus

2-s2.0-84896746469

Klíčová slova anglicky

Ionizing radiation; Acute radiation disease; Survival; Adenosine A(3) receptor agonist; Cyclooxygenase-2 inhibitor

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2014 15:36, Soňa Böhmová

Anotace

V originále

There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. The findings add new knowledge on the action of an adenosine A(3) receptor agonist and a COX-2 inhibitor in an irradiated mammalian organism and suggest the potential of both the investigated drugs in the treatment of the acute radiation damage.

Návaznosti

GA305/08/0158, projekt VaV

Název: Aktivace adenosinových receptorů kombinovaná s inhibicí cyklooxygenázy v modulaci zářením vyvolaného poškození kostní dřeně

Investor: Grantová agentura ČR, Aktivace adenosinových receptorů kompbinovaná s inhibicí cyklooxygenázy v modulaci zářením vyvolavaného poškození kostní dřeně

Citovat

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMURKOVA. Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice. Radiation and Environmental Biophysics. New York: Springer-Verlag, 2014, roč. 53, č. 1, s. 211-215. ISSN 0301-634X. Dostupné z: https://doi.org/10.1007/s00411-013-0500-y.

@article{1185415,
   author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Komurkova, Denisa},
   article_location = {New York},
   article_number = {1},
   doi = {https://doi.org/10.1007/s00411-013-0500-y},
   keywords = {Ionizing radiation; Acute radiation disease; Survival; Adenosine A(3) receptor agonist; Cyclooxygenase-2 inhibitor},
   language = {eng},
   issn = {0301-634X},
   journal = {Radiation and Environmental Biophysics},
   title = {Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice},
   volume = {53},
   year = {2014}
}

TY  - JOUR
ID  - 1185415
AU  - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Komurkova, Denisa
PY  - 2014
TI  - Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
JF  - Radiation and Environmental Biophysics
VL  - 53
IS  - 1
SP  - 211-215
EP  - 211-215
PB  - Springer-Verlag
SN  - 0301634X
KW  - Ionizing radiation
KW  - Acute radiation disease
KW  - Survival
KW  - Adenosine A(3) receptor agonist
KW  - Cyclooxygenase-2 inhibitor
N2  - There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to evaluate survival parameters in mice exposed to a lethal gamma-ray dose of 8.5 Gy and treated with single doses of an adenosine A(3) receptor agonist, IB-MECA, or a cyclooxygenase-2 (COX-2) inhibitor, meloxicam, administered alone or in a combination early after irradiation, i.e., 0.5 and 1 h post-irradiation, respectively. The assessed parameters were the mean survival time (MST) and the cumulative percentage 30-day survival (CPS). Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation or meloxicam 1 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice. Combined administration of IB-MECA and meloxicam was found to be the only treatment statistically enhancing the parameter of CPS and to lead to the most expressive increase in MST of the experimental mice. The findings add new knowledge on the action of an adenosine A(3) receptor agonist and a COX-2 inhibitor in an irradiated mammalian organism and suggest the potential of both the investigated drugs in the treatment of the acute radiation damage.
ER  -

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMURKOVA. Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice. \textit{Radiation and Environmental Biophysics}. New York: Springer-Verlag, 2014, roč.~53, č.~1, s.~211-215. ISSN~0301-634X. Dostupné z: https://doi.org/10.1007/s00411-013-0500-y.

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