Combined pharmacological therapy of the acute radiation disease
using a cyclooxygenase-2 inhibitor and an adenosine A(3)
receptor agonist

J 2014

Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ; Denisa KOMŮRKOVÁ et al.

Základní údaje

Originální název

Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist

Autoři

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMŮRKOVÁ

Vydání

Central European Journal of Biology, WARSAW, Springer Versita, 2014, 1895-104X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.710

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075665

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Hematopoiesis; Radiation-induced myelosuppression; Post-radiation pharmacological approach; Cyclooxygenase inhibition; Adenosine receptor agonist

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2015 10:56, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Combined approaches to the treatment of acute radiation disease are preferred to single-agent therapies due to proven or anticipated better outcomes comprising increased therapeutic efficacy and decreased incidence of undesirable side effects. Our studies on post-exposure treatment of mice irradiated by sublethal or lethal doses of ionizing radiation included testing the effectiveness of meloxicam, a cyclooxygenase-2 inhibitor, and IB-MECA, an adenosine A3 receptor agonist. The efficacy of meloxicam and IB-MECA to positively influence the progress of the acute radiation disease has been tested in situations of their combined administration with granulocyte colony-stimulating factor (G-CSF) or with each other. The results of our studies revealed a significantly improved regeneration of hematopoietic cell populations ranging from the bone marrow progenitor cells to mature blood cells following combined treatments. Also, survival of mice exposed to lethal radiation doses was highest in the animals treated with a combination of the two drugs. It can be inferred from the results that if the drug combinations employed were used in humans, e.g. in the treatment of victims of radiation accidents, a better therapeutic outcome could be expected. Therefore, further studies directed at clinical applications of meloxicam and IB-MECA in radiation victims is recommended.

Citovat

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMŮRKOVÁ. Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist. Central European Journal of Biology. WARSAW: Springer Versita, 2014, roč. 9, č. 6, s. 642-646. ISSN 1895-104X. Dostupné z: https://doi.org/10.2478/s11535-014-0295-0.

@article{1185416,
   author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Komůrková, Denisa},
   article_location = {WARSAW},
   article_number = {6},
   doi = {https://doi.org/10.2478/s11535-014-0295-0},
   keywords = {Hematopoiesis; Radiation-induced myelosuppression; Post-radiation pharmacological approach; Cyclooxygenase inhibition; Adenosine receptor agonist},
   language = {eng},
   issn = {1895-104X},
   journal = {Central European Journal of Biology},
   title = {Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist},
   volume = {9},
   year = {2014}
}

TY  - JOUR
ID  - 1185416
AU  - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Komůrková, Denisa
PY  - 2014
TI  - Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist
JF  - Central European Journal of Biology
VL  - 9
IS  - 6
SP  - 642-646
EP  - 642-646
PB  - Springer Versita
SN  - 1895104X
KW  - Hematopoiesis
KW  - Radiation-induced myelosuppression
KW  - Post-radiation pharmacological approach
KW  - Cyclooxygenase inhibition
KW  - Adenosine receptor agonist
N2  - Combined approaches to the treatment of acute radiation disease are preferred to single-agent therapies due to proven or anticipated better outcomes comprising increased therapeutic efficacy and decreased incidence of undesirable side effects. Our studies on post-exposure treatment of mice irradiated by sublethal or lethal doses of ionizing radiation included testing the effectiveness of meloxicam, a cyclooxygenase-2 inhibitor, and IB-MECA, an adenosine A3 receptor agonist. The efficacy of meloxicam and IB-MECA to positively influence the progress of the acute radiation disease has been tested in situations of their combined administration with granulocyte colony-stimulating factor (G-CSF) or with each other. The results of our studies revealed a significantly improved regeneration of hematopoietic cell populations ranging from the bone marrow progenitor cells to mature blood cells following combined treatments. Also, survival of mice exposed to lethal radiation doses was highest in the animals treated with a combination of the two drugs. It can be inferred from the results that if the drug combinations employed were used in humans, e.g. in the treatment of victims of radiation accidents, a better therapeutic outcome could be expected. Therefore, further studies directed at clinical applications of meloxicam and IB-MECA in radiation victims is recommended.
ER  -

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMŮRKOVÁ. Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist. \textit{Central European Journal of Biology}. WARSAW: Springer Versita, 2014, roč.~9, č.~6, s.~642-646. ISSN~1895-104X. Dostupné z: https://doi.org/10.2478/s11535-014-0295-0.

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