ZAAL, Afra, Ronald P. ZWEEMER, Michal ZIKÁN, Ladislav DUŠEK, Denid QUERLEU, Fabrice LÉCURU, Anne Sophie BATS, Robert JACH, Libor SEVCIK, Petar GRAF, Jaroslav KLAT, Grzegorz DYDUCH, Silvia von MENSDORFF-POULLY, Gemma G. KENTER, René H.M. VERHEIJEN a David CIBULA. Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, 2014, roč. 24, č. 2, s. 303-311. ISSN 1048-891X. Dostupné z: https://dx.doi.org/10.1097/IGC.0000000000000043. |
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@article{1185523, author = {Zaal, Afra and Zweemer, Ronald P. and Zikán, Michal and Dušek, Ladislav and Querleu, Denid and Lécuru, Fabrice and Bats, Anne Sophie and Jach, Robert and Sevcik, Libor and Graf, Petar and Klat, Jaroslav and Dyduch, Grzegorz and MensdorffandPoully, Silvia von and Kenter, Gemma G. and Verheijen, René H.M. and Cibula, David}, article_location = {PHILADELPHIA}, article_number = {2}, doi = {http://dx.doi.org/10.1097/IGC.0000000000000043}, keywords = {Isolated tumor cells; Low-volume disease; Lymph node dissection; Lymph node metastasis; Micrometastasis; Sentinel lymph node; Survival; Uterine cervical cancer}, language = {eng}, issn = {1048-891X}, journal = {INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER}, title = {Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study}, volume = {24}, year = {2014} }
TY - JOUR ID - 1185523 AU - Zaal, Afra - Zweemer, Ronald P. - Zikán, Michal - Dušek, Ladislav - Querleu, Denid - Lécuru, Fabrice - Bats, Anne Sophie - Jach, Robert - Sevcik, Libor - Graf, Petar - Klat, Jaroslav - Dyduch, Grzegorz - Mensdorff-Poully, Silvia von - Kenter, Gemma G. - Verheijen, René H.M. - Cibula, David PY - 2014 TI - Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study JF - INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER VL - 24 IS - 2 SP - 303-311 EP - 303-311 PB - LIPPINCOTT WILLIAMS & WILKINS SN - 1048891X KW - Isolated tumor cells KW - Low-volume disease KW - Lymph node dissection KW - Lymph node metastasis KW - Micrometastasis KW - Sentinel lymph node KW - Survival KW - Uterine cervical cancer N2 - Objective: In this study, we aimed to describe the value of pelvic lymph node dissection (LND) after sentinel lymph node (SN) biopsy in early-stage cervical cancer. Methods: We performed a retrospective multicenter cohort study in 8 gynecological oncology departments. In total, 645 women with International Federation of Gynecology and Obstetrics stage IA to IIB cervical cancer of squamous, adeno, or adenosquamous histologic type who underwent SN biopsy followed by pelvic LND were enrolled in this study. Radioisotope tracers and blue dyewere used to localize the sentinel node, and pathologic ultrastaging was performed. Results: Among the patients with low-volume disease (micrometastases and isolated tumor cells) in the sentinel node, the overall survivalwas significantly better (P = 0.046) ifmore than 16 non-SNs were removed. No such significant difference in survivalwas detected in patients with negative or macrometastatic sentinel nodes. Conclusions: Our findings indicate that in patients with negative or macrometastatic disease in the sentinel nodes, an additional LND did not alter survival. Conversely, our data suggest that the survival of patients with low-volume disease is improved when more than 16 additional lymph nodes are removed. If in a prospective trial our data are confirmed, we would suggest a 2-stage operation. ER -
ZAAL, Afra, Ronald P. ZWEEMER, Michal ZIKÁN, Ladislav DUŠEK, Denid QUERLEU, Fabrice LÉCURU, Anne Sophie BATS, Robert JACH, Libor SEVCIK, Petar GRAF, Jaroslav KLAT, Grzegorz DYDUCH, Silvia von MENSDORFF-POULLY, Gemma G. KENTER, René H.M. VERHEIJEN a David CIBULA. Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study. \textit{INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2014, roč.~24, č.~2, s.~303-311. ISSN~1048-891X. Dostupné z: https://dx.doi.org/10.1097/IGC.0000000000000043.
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