Pelvic lymphadenectomy improves survival in patients with
cervical cancer with low-volume disease in the sentinel node: A
retrospective multicenter cohort study

J 2014

Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study

ZAAL, Afra; Ronald P. ZWEEMER; Michal ZIKÁN; Ladislav DUŠEK; Denid QUERLEU et al.

Základní údaje

Originální název

Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study

Autoři

Vydání

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, PHILADELPHIA, LIPPINCOTT WILLIAMS & WILKINS, 2014, 1048-891X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.958

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075682

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Isolated tumor cells; Low-volume disease; Lymph node dissection; Lymph node metastasis; Micrometastasis; Sentinel lymph node; Survival; Uterine cervical cancer

Štítky

EL OK

Příznaky

Recenzováno

Změněno: 24. 4. 2015 13:05, Soňa Böhmová

Anotace

V originále

Objective: In this study, we aimed to describe the value of pelvic lymph node dissection (LND) after sentinel lymph node (SN) biopsy in early-stage cervical cancer. Methods: We performed a retrospective multicenter cohort study in 8 gynecological oncology departments. In total, 645 women with International Federation of Gynecology and Obstetrics stage IA to IIB cervical cancer of squamous, adeno, or adenosquamous histologic type who underwent SN biopsy followed by pelvic LND were enrolled in this study. Radioisotope tracers and blue dyewere used to localize the sentinel node, and pathologic ultrastaging was performed. Results: Among the patients with low-volume disease (micrometastases and isolated tumor cells) in the sentinel node, the overall survivalwas significantly better (P = 0.046) ifmore than 16 non-SNs were removed. No such significant difference in survivalwas detected in patients with negative or macrometastatic sentinel nodes. Conclusions: Our findings indicate that in patients with negative or macrometastatic disease in the sentinel nodes, an additional LND did not alter survival. Conversely, our data suggest that the survival of patients with low-volume disease is improved when more than 16 additional lymph nodes are removed. If in a prospective trial our data are confirmed, we would suggest a 2-stage operation.

Citovat

ZAAL, Afra; Ronald P. ZWEEMER; Michal ZIKÁN; Ladislav DUŠEK; Denid QUERLEU; Fabrice LÉCURU; Anne Sophie BATS; Robert JACH; Libor SEVCIK; Petar GRAF; Jaroslav KLAT; Grzegorz DYDUCH; Silvia von MENSDORFF-POULLY; Gemma G. KENTER; René H.M. VERHEIJEN a David CIBULA. Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, 2014, roč. 24, č. 2, s. 303-311. ISSN 1048-891X. Dostupné z: https://doi.org/10.1097/IGC.0000000000000043.

@article{1185523,
   author = {Zaal, Afra and Zweemer, Ronald P. and Zikán, Michal and Dušek, Ladislav and Querleu, Denid and Lécuru, Fabrice and Bats, Anne Sophie and Jach, Robert and Sevcik, Libor and Graf, Petar and Klat, Jaroslav and Dyduch, Grzegorz and MensdorffandPoully, Silvia von and Kenter, Gemma G. and Verheijen, René H.M. and Cibula, David},
   article_location = {PHILADELPHIA},
   article_number = {2},
   doi = {https://doi.org/10.1097/IGC.0000000000000043},
   keywords = {Isolated tumor cells; Low-volume disease; Lymph node dissection; Lymph node metastasis; Micrometastasis; Sentinel lymph node; Survival; Uterine cervical cancer},
   language = {eng},
   issn = {1048-891X},
   journal = {INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER},
   title = {Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study},
   volume = {24},
   year = {2014}
}

TY  - JOUR
ID  - 1185523
AU  - Zaal, Afra - Zweemer, Ronald P. - Zikán, Michal - Dušek, Ladislav - Querleu, Denid - Lécuru, Fabrice - Bats, Anne Sophie - Jach, Robert - Sevcik, Libor - Graf, Petar - Klat, Jaroslav - Dyduch, Grzegorz - Mensdorff-Poully, Silvia von - Kenter, Gemma G. - Verheijen, René H.M. - Cibula, David
PY  - 2014
TI  - Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study
JF  - INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
VL  - 24
IS  - 2
SP  - 303-311
EP  - 303-311
PB  - LIPPINCOTT WILLIAMS & WILKINS
SN  - 1048891X
KW  - Isolated tumor cells
KW  - Low-volume disease
KW  - Lymph node dissection
KW  - Lymph node metastasis
KW  - Micrometastasis
KW  - Sentinel lymph node
KW  - Survival
KW  - Uterine cervical cancer
N2  - Objective: In this study, we aimed to describe the value of pelvic lymph node dissection (LND) after sentinel lymph node (SN) biopsy in early-stage cervical cancer. Methods: We performed a retrospective multicenter cohort study in 8 gynecological oncology departments. In total, 645 women with International Federation of Gynecology and Obstetrics stage IA to IIB cervical cancer of squamous, adeno, or adenosquamous histologic type who underwent SN biopsy followed by pelvic LND were enrolled in this study. Radioisotope tracers and blue dyewere used to localize the sentinel node, and pathologic ultrastaging was performed. Results: Among the patients with low-volume disease (micrometastases and isolated tumor cells) in the sentinel node, the overall survivalwas significantly better (P = 0.046) ifmore than 16 non-SNs were removed. No such significant difference in survivalwas detected in patients with negative or macrometastatic sentinel nodes. Conclusions: Our findings indicate that in patients with negative or macrometastatic disease in the sentinel nodes, an additional LND did not alter survival. Conversely, our data suggest that the survival of patients with low-volume disease is improved when more than 16 additional lymph nodes are removed. If in a prospective trial our data are confirmed, we would suggest a 2-stage operation.
ER  -

ZAAL, Afra; Ronald P. ZWEEMER; Michal ZIKÁN; Ladislav DUŠEK; Denid QUERLEU; Fabrice LÉCURU; Anne Sophie BATS; Robert JACH; Libor SEVCIK; Petar GRAF; Jaroslav KLAT; Grzegorz DYDUCH; Silvia von MENSDORFF-POULLY; Gemma G. KENTER; René H.M. VERHEIJEN a David CIBULA. Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: A retrospective multicenter cohort study. \textit{INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2014, roč.~24, č.~2, s.~303-311. ISSN~1048-891X. Dostupné z: https://doi.org/10.1097/IGC.0000000000000043.

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