Cytotoxic Constituents from Lobaria scrobiculata and a
Comparison of Two Bioassays for Their Evaluation

J 2014

Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation

SCHINKOVITZ, Andreas; Avinash Kaur KANG; Ernst URBAN; Martin ZEHL; Gabriela PÁCHNIKOVÁ et al.

Základní údaje

Originální název

Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation

Autoři

Vydání

Journal of Natural Products, Washington, American Chemical Society, 2014, 0163-3864

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.798

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075701

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

USNEA-LONGISSIMA; LICHEN; ACID; PULMONARIA

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 6. 2014 15:24, Soňa Böhmová

Anotace

V originále

Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.

Citovat

SCHINKOVITZ, Andreas; Avinash Kaur KANG; Ernst URBAN; Martin ZEHL; Gabriela PÁCHNIKOVÁ; Yuehong WANG; Nadine KRETSCHMER; Iva SLANINOVÁ; Guido F. PAULI; Scott G. FRANZBLAU; Georg KRUPITZA; Rudolf BAUER a Brigitte KOPP. Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation. Journal of Natural Products. Washington: American Chemical Society, 2014, roč. 77, č. 4, s. 1069-1073. ISSN 0163-3864. Dostupné z: https://doi.org/10.1021/np4008574.

@article{1185588,
   author = {Schinkovitz, Andreas and Kang, Avinash Kaur and Urban, Ernst and Zehl, Martin and Páchniková, Gabriela and Wang, Yuehong and Kretschmer, Nadine and Slaninová, Iva and Pauli, Guido F. and Franzblau, Scott G. and Krupitza, Georg and Bauer, Rudolf and Kopp, Brigitte},
   article_location = {Washington},
   article_number = {4},
   doi = {https://doi.org/10.1021/np4008574},
   keywords = {USNEA-LONGISSIMA; LICHEN; ACID; PULMONARIA},
   language = {eng},
   issn = {0163-3864},
   journal = {Journal of Natural Products},
   title = {Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation},
   volume = {77},
   year = {2014}
}

TY  - JOUR
ID  - 1185588
AU  - Schinkovitz, Andreas - Kang, Avinash Kaur - Urban, Ernst - Zehl, Martin - Páchniková, Gabriela - Wang, Yuehong - Kretschmer, Nadine - Slaninová, Iva - Pauli, Guido F. - Franzblau, Scott G. - Krupitza, Georg - Bauer, Rudolf - Kopp, Brigitte
PY  - 2014
TI  - Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation
JF  - Journal of Natural Products
VL  - 77
IS  - 4
SP  - 1069-1073
EP  - 1069-1073
PB  - American Chemical Society
SN  - 01633864
KW  - USNEA-LONGISSIMA
KW  - LICHEN
KW  - ACID
KW  - PULMONARIA
N2  - Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.
ER  -

SCHINKOVITZ, Andreas; Avinash Kaur KANG; Ernst URBAN; Martin ZEHL; Gabriela PÁCHNIKOVÁ; Yuehong WANG; Nadine KRETSCHMER; Iva SLANINOVÁ; Guido F. PAULI; Scott G. FRANZBLAU; Georg KRUPITZA; Rudolf BAUER a Brigitte KOPP. Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation. \textit{Journal of Natural Products}. Washington: American Chemical Society, 2014, roč.~77, č.~4, s.~1069-1073. ISSN~0163-3864. Dostupné z: https://doi.org/10.1021/np4008574.

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