Long-term outcome and predictors of resective surgery prognosis
in patients with refractory extratemporal epilepsy

J 2014

Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy

HANÁKOVÁ, Petra; Milan BRÁZDIL; Zdeněk NOVÁK; Jan HEMZA; Jan CHRASTINA et al.

Základní údaje

Originální název

Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy

Autoři

HANÁKOVÁ, Petra; Milan BRÁZDIL; Zdeněk NOVÁK; Jan HEMZA; Jan CHRASTINA; Hana OŠLEJŠKOVÁ; Markéta HERMANOVÁ; Marta PAŽOURKOVÁ; Ivan REKTOR a Robert KUBA

Vydání

Seizure, Elsevier, 2014, 1059-1311

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.822

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075760

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Epilepsy surgery; Extratemporal; Long-term outcome; Histopathology; Engel's classification

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 12. 2014 12:25, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Purpose: We analyzed the long-term postoperative outcome and possible predictive factors of the outcome in surgically treated patients with refractory extratemporal epilepsy. Methods: We retrospectively analyzed 73 patients who had undergone resective surgery at the Epilepsy Center Brno between 1995 and 2010 and who had reached at least 1 year outcome after the surgery. The average age at surgery was 28.3 +/- 11.4 years. Magnetic resonance imaging (MRI) did not reveal any lesion in 24 patients (32.9%). Surgical outcome was assessed annually using Engel's modified classification until 5 years after surgery and at the latest follow-up visit. Results: Following the surgery, Engel Class I outcome was found in 52.1% of patients after 1 year, in 55.0% after 5 years, and in 50.7% at the last follow-up visit (average 6.15 +/- 3.84 years). Of the patients who reached the 5-year follow-up visit (average of the last follow-up 9.23 years), 37.5% were classified as Engel IA at each follow-up visit. Tumorous etiology and lesions seen in preoperative MRI were associated with significantly better outcome (p = 0.035; p < 0.01). Postoperatively, 9.6% patients had permanent neurological deficits. Conclusion: Surgical treatment of refractory extratemporal epilepsy is an effective procedure. The presence of a visible MRI-detected lesion and tumorous etiology is associated with significantly better outcome than the absence of MRI-detected lesion or other etiology.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Přiložené soubory

EL_1186438.pdf

Požádat o autorskou verzi souboru

Citovat

HANÁKOVÁ, Petra; Milan BRÁZDIL; Zdeněk NOVÁK; Jan HEMZA; Jan CHRASTINA; Hana OŠLEJŠKOVÁ; Markéta HERMANOVÁ; Marta PAŽOURKOVÁ; Ivan REKTOR a Robert KUBA. Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy. Seizure. Elsevier, 2014, roč. 23, č. 4, s. 266-273. ISSN 1059-1311. Dostupné z: https://doi.org/10.1016/j.seizure.2013.12.003.

@article{1186438,
   author = {Hanáková, Petra and Brázdil, Milan and Novák, Zdeněk and Hemza, Jan and Chrastina, Jan and Ošlejšková, Hana and Hermanová, Markéta and Pažourková, Marta and Rektor, Ivan and Kuba, Robert},
   article_number = {4},
   doi = {https://doi.org/10.1016/j.seizure.2013.12.003},
   keywords = {Epilepsy surgery; Extratemporal; Long-term outcome; Histopathology; Engel's classification},
   language = {eng},
   issn = {1059-1311},
   journal = {Seizure},
   title = {Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy},
   volume = {23},
   year = {2014}
}

TY  - JOUR
ID  - 1186438
AU  - Hanáková, Petra - Brázdil, Milan - Novák, Zdeněk - Hemza, Jan - Chrastina, Jan - Ošlejšková, Hana - Hermanová, Markéta - Pažourková, Marta - Rektor, Ivan - Kuba, Robert
PY  - 2014
TI  - Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy
JF  - Seizure
VL  - 23
IS  - 4
SP  - 266-273
EP  - 266-273
PB  - Elsevier
SN  - 10591311
KW  - Epilepsy surgery
KW  - Extratemporal
KW  - Long-term outcome
KW  - Histopathology
KW  - Engel's classification
N2  - Purpose: We analyzed the long-term postoperative outcome and possible predictive factors of the outcome in surgically treated patients with refractory extratemporal epilepsy. Methods: We retrospectively analyzed 73 patients who had undergone resective surgery at the Epilepsy Center Brno between 1995 and 2010 and who had reached at least 1 year outcome after the surgery. The average age at surgery was 28.3 +/- 11.4 years. Magnetic resonance imaging (MRI) did not reveal any lesion in 24 patients (32.9%). Surgical outcome was assessed annually using Engel's modified classification until 5 years after surgery and at the latest follow-up visit. Results: Following the surgery, Engel Class I outcome was found in 52.1% of patients after 1 year, in 55.0% after 5 years, and in 50.7% at the last follow-up visit (average 6.15 +/- 3.84 years). Of the patients who reached the 5-year follow-up visit (average of the last follow-up 9.23 years), 37.5% were classified as Engel IA at each follow-up visit. Tumorous etiology and lesions seen in preoperative MRI were associated with significantly better outcome (p = 0.035; p < 0.01). Postoperatively, 9.6% patients had permanent neurological deficits. Conclusion: Surgical treatment of refractory extratemporal epilepsy is an effective procedure. The presence of a visible MRI-detected lesion and tumorous etiology is associated with significantly better outcome than the absence of MRI-detected lesion or other etiology.
ER  -

HANÁKOVÁ, Petra; Milan BRÁZDIL; Zdeněk NOVÁK; Jan HEMZA; Jan CHRASTINA; Hana OŠLEJŠKOVÁ; Markéta HERMANOVÁ; Marta PAŽOURKOVÁ; Ivan REKTOR a Robert KUBA. Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy. \textit{Seizure}. Elsevier, 2014, roč.~23, č.~4, s.~266-273. ISSN~1059-1311. Dostupné z: https://doi.org/10.1016/j.seizure.2013.12.003.

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