Clinical significance of head and neck squamous cell cancer
biomarkers

J 2014

Clinical significance of head and neck squamous cell cancer biomarkers

POLANSKÁ, Hana; Martina RAUDENSKÁ; Jaromír GUMULEC; Markéta SZTALMACHOVÁ; Vojtěch ADAM et al.

Základní údaje

Originální název

Clinical significance of head and neck squamous cell cancer biomarkers

Autoři

POLANSKÁ, Hana; Martina RAUDENSKÁ ; Jaromír GUMULEC; Markéta SZTALMACHOVÁ; Vojtěch ADAM; René KIZEK a Michal MASAŘÍK

Vydání

Oral oncology, Amsterdam, Elsevier Science, 2014, 1368-8375

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.607

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00080138

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Head and neck cancer; Tumor markers; Cancer; Prognosis; Papillomavirus; miRNA; Saliva

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 6. 2014 13:52, Soňa Böhmová

Anotace

V originále

Head and neck tumors belong among the six leading causes of cancer death worldwide. The predominant type of head and neck tumors consists of squamous cell carcinomas (HNSCC). Early detection of primary tumor and relapse is a key factor for enhancing the survival rate of HNSCC patients, because high rates of cases are recognized at advanced stages. Accordingly, biomarkers suitable for the early detection of HNSCC are sorely needed to improve patient outcomes. HNSCC evolve through a multistep process by the accumulation of genetic and phenotypic changes. Searching for specific biomarkers capable of characterizing each degree is therefore really essential. In this review, genomic and gene expression alterations of HNSCC are summarized and associated with HPV status, clinicopathological conditions, and patient history from the perspective of potential biomarker utilization. The emphasis is placed on non-invasive markers detectable from saliva and blood and clinically relevant studies are mentioned in particular. These include analyses of tumorous tissues, saliva, and blood from patients with histologically defined tumors; cell culture-and other in vitro-based studies with no clinical correlations are rather excluded.

Návaznosti

NT14337, projekt VaV

Název: Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.

Investor: Ministerstvo zdravotnictví ČR, Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.

Citovat

POLANSKÁ, Hana; Martina RAUDENSKÁ; Jaromír GUMULEC; Markéta SZTALMACHOVÁ; Vojtěch ADAM; René KIZEK a Michal MASAŘÍK. Clinical significance of head and neck squamous cell cancer biomarkers. Oral oncology. Amsterdam: Elsevier Science, 2014, roč. 50, č. 3, s. 168-177. ISSN 1368-8375. Dostupné z: https://doi.org/10.1016/j.oraloncology.2013.12.008.

@article{1187244,
   author = {Polanská, Hana and Raudenská, Martina and Gumulec, Jaromír and Sztalmachová, Markéta and Adam, Vojtěch and Kizek, René and Masařík, Michal},
   article_location = {Amsterdam},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.oraloncology.2013.12.008},
   keywords = {Head and neck cancer; Tumor markers; Cancer; Prognosis; Papillomavirus; miRNA; Saliva},
   language = {eng},
   issn = {1368-8375},
   journal = {Oral oncology},
   title = {Clinical significance of head and neck squamous cell cancer biomarkers},
   volume = {50},
   year = {2014}
}

TY  - JOUR
ID  - 1187244
AU  - Polanská, Hana - Raudenská, Martina - Gumulec, Jaromír - Sztalmachová, Markéta - Adam, Vojtěch - Kizek, René - Masařík, Michal
PY  - 2014
TI  - Clinical significance of head and neck squamous cell cancer biomarkers
JF  - Oral oncology
VL  - 50
IS  - 3
SP  - 168-177
EP  - 168-177
PB  - Elsevier Science
SN  - 13688375
KW  - Head and neck cancer
KW  - Tumor markers
KW  - Cancer
KW  - Prognosis
KW  - Papillomavirus
KW  - miRNA
KW  - Saliva
N2  - Head and neck tumors belong among the six leading causes of cancer death worldwide. The predominant type of head and neck tumors consists of squamous cell carcinomas (HNSCC). Early detection of primary tumor and relapse is a key factor for enhancing the survival rate of HNSCC patients, because high rates of cases are recognized at advanced stages. Accordingly, biomarkers suitable for the early detection of HNSCC are sorely needed to improve patient outcomes. HNSCC evolve through a multistep process by the accumulation of genetic and phenotypic changes. Searching for specific biomarkers capable of characterizing each degree is therefore really essential. In this review, genomic and gene expression alterations of HNSCC are summarized and associated with HPV status, clinicopathological conditions, and patient history from the perspective of potential biomarker utilization. The emphasis is placed on non-invasive markers detectable from saliva and blood and clinically relevant studies are mentioned in particular. These include analyses of tumorous tissues, saliva, and blood from patients with histologically defined tumors; cell culture-and other in vitro-based studies with no clinical correlations are rather excluded.
ER  -

POLANSKÁ, Hana; Martina RAUDENSKÁ; Jaromír GUMULEC; Markéta SZTALMACHOVÁ; Vojtěch ADAM; René KIZEK a Michal MASAŘÍK. Clinical significance of head and neck squamous cell cancer biomarkers. \textit{Oral oncology}. Amsterdam: Elsevier Science, 2014, roč.~50, č.~3, s.~168-177. ISSN~1368-8375. Dostupné z: https://doi.org/10.1016/j.oraloncology.2013.12.008.

Přehled o publikaci