DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES
CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM

a 2013

DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM

HAVRÁNKOVÁ, Eva a Pavel PAZDERA

Základní údaje

Originální název

DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM

Autoři

HAVRÁNKOVÁ, Eva (203 Česká republika, domácí) a Pavel PAZDERA (203 Česká republika, garant, domácí)

Vydání

15th Blue Danube Symposium on Heterocyclic Chemistry, 2013

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10401 Organic chemistry

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/13:00074528

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-80-263-0502-6

Klíčová slova česky

Dihydropyrimidinones; 1 5-Benzodiazepines; Metal catalysis; Polymer supported Ce(III); Solid support catalysis.

Klíčová slova anglicky

Dihydropyrimidinones; 1 5-Benzodiazepines; Metal catalysis; Polymer supported Ce(III); Solid support catalysis.

Změněno: 27. 6. 2014 14:44, doc. RNDr. Pavel Pazdera, CSc.

Anotace

V originále

One of the possibilities to sophisticate compound syntheses is catalysis using supported catalyst which combines the advantages of both homogeneous and heterogeneous catalyst. An application of Ce(III) inorganic salts, first of all CeCl3.7H2O doped by sodium iodide, not until has been described from start of 21st Century. Twenty communications has been present during this time only. Catalysis by Ce(III) salts has been used for an activation of carbonyl compounds and their derivatives in syntheses. Easily available, cheap and mechanically and thermally stable industrial cation-exchangers may be used as carriers1. These in connection with complex of cerium in oxidation state of 3+ provide an effective, easily separable and recyclable catalytic system. This system has been studied with a view to its possible synthetic applications on model domino syntheses, i.e. three-component four-step domino synthesis of substituted 1,5- benzodiazepines2, and three-component four-step domino synthesis of substituted 3,4- dihydropyrimidin-2(1H)-ones3, respectively. It has been discovered that cation Ce(III) supported on a weak acid macroporous cation-exchanger has shown in the studied reactions at least the same or better catalytic activity as salt CeCl3.7H2O, eventually doped by NaI.

Návaznosti

2A-1TP1/090, projekt VaV

Název: Nové katalyzátory a činidla pro udržitelné zelené syntézy a kombinatoriální syntézy.

Investor: Ministerstvo průmyslu a obchodu ČR, Nové katalyzátory a činidla pro udržitelné zelené syntézy a kombinatoriální syntézy

Citovat

HAVRÁNKOVÁ, Eva a Pavel PAZDERA. DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM. In 15th Blue Danube Symposium on Heterocyclic Chemistry. 2013. ISBN 978-80-263-0502-6.

@proceedings{1187364,
   author = {Havránková, Eva and Pazdera, Pavel},
   booktitle = {15th Blue Danube Symposium on Heterocyclic Chemistry},
   keywords = {Dihydropyrimidinones; 1 5-Benzodiazepines; Metal catalysis; Polymer supported Ce(III); Solid support catalysis.},
   language = {eng},
   isbn = {978-80-263-0502-6},
   title = {DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM},
   year = {2013}
}

TY  - CONF
ID  - 1187364
AU  - Havránková, Eva - Pazdera, Pavel
PY  - 2013
TI  - DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM
SN  - 9788026305026
KW  - Dihydropyrimidinones
KW  - 1 5-Benzodiazepines
KW  - Metal catalysis
KW  - Polymer supported Ce(III)
KW  - Solid support catalysis.
N2  - One of the possibilities to sophisticate compound syntheses is catalysis using supported catalyst which combines the advantages of both homogeneous and heterogeneous catalyst. An application of Ce(III) inorganic salts, first of all CeCl3.7H2O doped by sodium iodide, not until has been described from start of 21st Century. Twenty communications has been present during this time only. Catalysis by Ce(III) salts has been used for an activation of carbonyl compounds and their derivatives in syntheses. Easily available, cheap and mechanically and thermally stable industrial cation-exchangers may be used as carriers1. These in connection with complex of cerium in oxidation state of 3+ provide an effective, easily separable and recyclable catalytic system. This system has been studied with a view to its possible synthetic applications on model domino syntheses, i.e. three-component four-step domino synthesis of substituted 1,5- benzodiazepines2, and three-component four-step domino synthesis of substituted 3,4- dihydropyrimidin-2(1H)-ones3, respectively. It has been discovered that cation Ce(III) supported on a weak acid macroporous cation-exchanger has shown in the studied reactions at least the same or better catalytic activity as salt CeCl3.7H2O, eventually doped by NaI.
ER  -

HAVRÁNKOVÁ, Eva a Pavel PAZDERA. DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM. In \textit{15th Blue Danube Symposium on Heterocyclic Chemistry}. 2013. ISBN~978-80-263-0502-6.

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