TaqI polymorphism in the vitamin D receptor (VDR) and its
relation to aggressive and chronic periodontitis in Czech
population

k 2014

TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population

MAGURA, Matej, Petra BOŘILOVÁ LINHARTOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Základní údaje

Originální název

TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population

Autoři

MAGURA, Matej, Petra BOŘILOVÁ LINHARTOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

IADS & YDW MidYear Meeting 2014, Tunisia, 2014

Další údaje

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

Klíčová slova anglicky

periodontitis, TaqI, VDR, Czech population

Změněno: 30. 6. 2014 07:36, doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA

Anotace

V originále

Objective: Periodontitis is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to analyze a single nucleotide polymorphism (SNP) in the VDR gene, which may affect the functional activity of the VDR protein, in Czech patients with aggressive (AgP) and chronic periodontitis (CP). Methods: In this case-control study 448 unrelated subjects were included. Genomic DNA of 67 patients with AgP, 305 patients with CP and 76 healthy/non-periodontitis controls were genotyped. For TaqI VDR (rs731236) gene polymorphism the method based on polymerase chain reaction (PCR) followed by restriction digest was used. Results: There was no evidence for a significant association between TaqI VDR polymorphism and CP, while allele frequencies of TaqI VDR polymorphism was significantly different between patients with AgP and non-periodontitis controls (P = 0.015). And although no difference was found in genotype frequencies in patients with AgP, statistically significant results were obtained after comparing the genotypes TT vs CT + CC (P = 0.034), in the subgroup of women (N = 40, P = 0.017). Conclusions: We can conclude relationship between the occurrence of the mutated allele (C) of TaqI VDR polymorphism and the development of aggressive forms of periodontitis, especially in women, but a correlation between mutation and chronic form of periodontitis was not found.

Návaznosti

NT11405, projekt VaV

Název: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministerstvo zdravotnictví ČR, Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Citovat

MAGURA, Matej, Petra BOŘILOVÁ LINHARTOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population. In IADS & YDW MidYear Meeting 2014, Tunisia. 2014.

@proceedings{1187916,
   author = {Magura, Matej and Bořilová Linhartová, Petra and Izakovičová Hollá, Lydie},
   booktitle = {IADS & YDW MidYear Meeting 2014, Tunisia},
   keywords = {periodontitis, TaqI, VDR, Czech population},
   title = {TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population},
   year = {2014}
}

TY  - CONF
ID  - 1187916
AU  - Magura, Matej - Bořilová Linhartová, Petra - Izakovičová Hollá, Lydie
PY  - 2014
TI  - TaqI polymorphism in the vitamin D receptor (VDR) and its relation to aggressive and chronic periodontitis in Czech population
KW  - periodontitis, TaqI, VDR, Czech population
N2  - Objective: Periodontitis is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to analyze a single nucleotide polymorphism (SNP) in the VDR gene, which may affect the functional activity of the VDR protein, in Czech patients with aggressive (AgP) and chronic periodontitis (CP). Methods: In this case-control study 448 unrelated subjects were included. Genomic DNA of 67 patients with AgP, 305 patients with CP and 76 healthy/non-periodontitis controls were genotyped. For TaqI VDR (rs731236) gene polymorphism the method based on polymerase chain reaction (PCR) followed by restriction digest was used. Results: There was no evidence for a significant association between TaqI VDR polymorphism and CP, while allele frequencies of TaqI VDR polymorphism was significantly different between patients with AgP and non-periodontitis controls (P = 0.015). And although no difference was found in genotype frequencies in patients with AgP, statistically significant results were obtained after comparing the genotypes TT vs CT + CC (P = 0.034), in the subgroup of women (N = 40, P = 0.017). Conclusions: We can conclude relationship between the occurrence of the mutated allele (C) of TaqI VDR polymorphism and the development of aggressive forms of periodontitis, especially in women, but a correlation between mutation and chronic form of periodontitis was not found.
ER  -

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