Pathophysiological characterization of drug hypersensitivity to
tribenoside

J 2014

Pathophysiological characterization of drug hypersensitivity to tribenoside

ZGAŽAROVÁ, Simona; Hana JEDLIČKOVÁ; Zita CHOVANCOVÁ a Vojtěch THON

Základní údaje

Originální název

Pathophysiological characterization of drug hypersensitivity to tribenoside

Autoři

ZGAŽAROVÁ, Simona; Hana JEDLIČKOVÁ; Zita CHOVANCOVÁ a Vojtěch THON

Vydání

Central European Journal of Medicine, Warsaw (Poland), Versita, 2014, 1895-1058

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.153

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00075892

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Basophil activation test; Benzoic acid; Drug hypersensitivity; Lymphocyte transformation test; Patch test; Tribenoside

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 7. 2014 17:04, Soňa Böhmová

Anotace

V originále

Tribenoside is a semisynthetic sugar derivative that is mainly indicated for treatment of chronic venous insufficiency. Up to 10% of patients treated by tribenoside can suffer from skin side effects. The adverse effects usually present as angioedema, urticaria, or maculopapular exanthema. The pathophysiology of the reaction has not as yet been elucidated. In this study, we examined 22 patients with drug eruptions caused by tribenoside. Patch tests were performed to investigate in vivo cellular reactions. Laboratory investigations were carried out by lymphocyte transformation tests and basophil activation tests. We found a positive patch test reaction to tribenoside in one patient. The lymphocyte transformation test elicited a borderline positive reaction in one patient, and the basophil activation test gave a clearly positive reaction in another patient. The diagnosis of drug hypersensitivity reactions is a challenge. Both delayed and immediate immunologic response may play a role in the etiology of tribenoside-induced exanthemas. Our investigation and results indicate that benzoic acid could be the antigenic determinant in drug hypersensitivity to tribenoside.

Citovat

ZGAŽAROVÁ, Simona; Hana JEDLIČKOVÁ; Zita CHOVANCOVÁ a Vojtěch THON. Pathophysiological characterization of drug hypersensitivity to tribenoside. Central European Journal of Medicine. Warsaw (Poland): Versita, 2014, roč. 9, č. 1, s. 159-168. ISSN 1895-1058. Dostupné z: https://doi.org/10.2478/s11536-013-0248-4.

@article{1188100,
   author = {Zgažarová, Simona and Jedličková, Hana and Chovancová, Zita and Thon, Vojtěch},
   article_location = {Warsaw (Poland)},
   article_number = {1},
   doi = {https://doi.org/10.2478/s11536-013-0248-4},
   keywords = {Basophil activation test; Benzoic acid; Drug hypersensitivity; Lymphocyte transformation test; Patch test; Tribenoside},
   language = {eng},
   issn = {1895-1058},
   journal = {Central European Journal of Medicine},
   title = {Pathophysiological characterization of drug hypersensitivity to tribenoside},
   volume = {9},
   year = {2014}
}

TY  - JOUR
ID  - 1188100
AU  - Zgažarová, Simona - Jedličková, Hana - Chovancová, Zita - Thon, Vojtěch
PY  - 2014
TI  - Pathophysiological characterization of drug hypersensitivity to tribenoside
JF  - Central European Journal of Medicine
VL  - 9
IS  - 1
SP  - 159-168
EP  - 159-168
PB  - Versita
SN  - 18951058
KW  - Basophil activation test
KW  - Benzoic acid
KW  - Drug hypersensitivity
KW  - Lymphocyte transformation test
KW  - Patch test
KW  - Tribenoside
N2  - Tribenoside is a semisynthetic sugar derivative that is mainly indicated for treatment of chronic venous insufficiency. Up to 10% of patients treated by tribenoside can suffer from skin side effects. The adverse effects usually present as angioedema, urticaria, or maculopapular exanthema. The pathophysiology of the reaction has not as yet been elucidated. In this study, we examined 22 patients with drug eruptions caused by tribenoside. Patch tests were performed to investigate in vivo cellular reactions. Laboratory investigations were carried out by lymphocyte transformation tests and basophil activation tests. We found a positive patch test reaction to tribenoside in one patient. The lymphocyte transformation test elicited a borderline positive reaction in one patient, and the basophil activation test gave a clearly positive reaction in another patient. The diagnosis of drug hypersensitivity reactions is a challenge. Both delayed and immediate immunologic response may play a role in the etiology of tribenoside-induced exanthemas. Our investigation and results indicate that benzoic acid could be the antigenic determinant in drug hypersensitivity to tribenoside.
ER  -

ZGAŽAROVÁ, Simona; Hana JEDLIČKOVÁ; Zita CHOVANCOVÁ a Vojtěch THON. Pathophysiological characterization of drug hypersensitivity to tribenoside. \textit{Central European Journal of Medicine}. Warsaw (Poland): Versita, 2014, roč.~9, č.~1, s.~159-168. ISSN~1895-1058. Dostupné z: https://doi.org/10.2478/s11536-013-0248-4.

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