ŠIMBERA, Jan, Richard ŠEVČÍK a Pavel PAZDERA. New one-pot methods for preparation of cyclohexanecarbonitrile – Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses. Green and Sustainable Chemistry. Delaware, USA: Scientific Research Publishing, 2014, roč. 2014, č. 4, s. 70-79. ISSN 2160-6951. Dostupné z: https://dx.doi.org/10.4236/gsc.2014.42011. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1188694, author = {Šimbera, Jan and Ševčík, Richard and Pazdera, Pavel}, article_location = {Delaware, USA}, article_number = {4}, doi = {http://dx.doi.org/10.4236/gsc.2014.42011}, keywords = {Cyclohexanecarbonitrile; One-Pot Synthesis; EcoScale; EATOS; SIS; Synthesis of Organic Molecules; Catalysis; Green and Sustainable Chemistry; Waste Management AT SOURCE.}, language = {eng}, issn = {2160-6951}, journal = {Green and Sustainable Chemistry}, title = {New one-pot methods for preparation of cyclohexanecarbonitrile – Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses}, url = {http://dx.doi.org/10.4236/gsc.2014.42011}, volume = {2014}, year = {2014} }
TY - JOUR ID - 1188694 AU - Šimbera, Jan - Ševčík, Richard - Pazdera, Pavel PY - 2014 TI - New one-pot methods for preparation of cyclohexanecarbonitrile – Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses JF - Green and Sustainable Chemistry VL - 2014 IS - 4 SP - 70-79 EP - 70-79 PB - Scientific Research Publishing SN - 21606951 KW - Cyclohexanecarbonitrile KW - One-Pot Synthesis KW - EcoScale KW - EATOS KW - SIS KW - Synthesis of Organic Molecules KW - Catalysis KW - Green and Sustainable Chemistry KW - Waste Management AT SOURCE. UR - http://dx.doi.org/10.4236/gsc.2014.42011 L2 - http://dx.doi.org/10.4236/gsc.2014.42011 N2 - Three new multi-step one-pot processes for high-yielding cyclohexanecarbonitrile synthesis starting from cyclohexanone were developed for industrial application. In contrast to the current synthetic process all of the processes described were designed to proceed completely in methanol as a uniform solvent and the key oxidation step can be realized either as stoichiometric or catalytic. Atom efficiency of processes is rel-atively advanced with high regioselectivity, reaction by-products are either from environmental pool – carbon dioxide and nitrogen or they can be reused – sodium chloride. Solvent – methanol and other aux-iliaries – cyclohexane, copper catalyst can be reused after recycling as well. EcoScale for all three designed processes was evaluated and compared with current synthesis described in the past. Green chemistry metrics, including newly introduced evaluative tool – Sustainability Index of the Synthesis (SIS), were applied to evaluate design of described one-pot syntheses. ER -
ŠIMBERA, Jan, Richard ŠEVČÍK a Pavel PAZDERA. New one-pot methods for preparation of cyclohexanecarbonitrile – Green Chemistry metrics evaluation for one-pot and similar multi-step syntheses. \textit{Green and Sustainable Chemistry}. Delaware, USA: Scientific Research Publishing, 2014, roč.~2014, č.~4, s.~70-79. ISSN~2160-6951. Dostupné z: https://dx.doi.org/10.4236/gsc.2014.42011.
|