The effects of biologically active substances in medicinal
plants on the metabolic activity of neutrophils

J 2014

The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils

LOJEK, Antonin; Petko DENEV; Milan CIZ; Ondřej VAŠÍČEK; Maria KRATCHANOVA et al.

Základní údaje

Originální název

The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils

Autoři

LOJEK, Antonin; Petko DENEV; Milan CIZ; Ondřej VAŠÍČEK a Maria KRATCHANOVA

Vydání

Phytochemistry Reviews, Dordrecht, Springer, 2014, 1568-7767

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.407

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00082081

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Phagocytes; Polyphenols; Polysaccharides; Reactive oxygen species; Terpenes

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 8. 2015 13:02, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Neutrophils are the typical effector cells of the innate immune response because they are the first leukocytes to be recruited to an inflammatory site where they engulf invading microorganisms and destroy them by multiple oxidative and non-oxidative mechanisms. The destructive potential of neutrophils requires the tight control of their recruitment into tissue compartments and the production of inflammatory mediators such as reactive oxygen species. These oxidants can be highly toxic not only for infectious agents but also for neighbouring host tissues resulting in various autoimmune and inflammatory diseases. Thus, a significant attention in medicine is paid to approaches designed to modulate the metabolic activity of neutrophils. Synthetic steroid and non-steroid compounds with adverse side effects are commonly used for this purpose. The effects of natural substances which can modulate the metabolic activity of neutrophils and which simultaneously would not exert any significant unfavourable side effects have recently been investigated. Suitable candidates for this purpose might be compounds contained in herbs. These include especially polysaccharides and polyphenols, but also terpenes. The aim of the present paper is to summarize contemporary knowledge on the effects of compounds from herbs on the metabolic activity of mammalian neutrophils.

Citovat

LOJEK, Antonin; Petko DENEV; Milan CIZ; Ondřej VAŠÍČEK a Maria KRATCHANOVA. The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils. Phytochemistry Reviews. Dordrecht: Springer, 2014, roč. 13, č. 2, s. 499-510. ISSN 1568-7767. Dostupné z: https://doi.org/10.1007/s11101-014-9340-x.

@article{1193853,
   author = {Lojek, Antonin and Denev, Petko and Ciz, Milan and Vašíček, Ondřej and Kratchanova, Maria},
   article_location = {Dordrecht},
   article_number = {2},
   doi = {https://doi.org/10.1007/s11101-014-9340-x},
   keywords = {Phagocytes; Polyphenols; Polysaccharides; Reactive oxygen species; Terpenes},
   language = {eng},
   issn = {1568-7767},
   journal = {Phytochemistry Reviews},
   title = {The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils},
   volume = {13},
   year = {2014}
}

TY  - JOUR
ID  - 1193853
AU  - Lojek, Antonin - Denev, Petko - Ciz, Milan - Vašíček, Ondřej - Kratchanova, Maria
PY  - 2014
TI  - The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils
JF  - Phytochemistry Reviews
VL  - 13
IS  - 2
SP  - 499-510
EP  - 499-510
PB  - Springer
SN  - 15687767
KW  - Phagocytes
KW  - Polyphenols
KW  - Polysaccharides
KW  - Reactive oxygen species
KW  - Terpenes
N2  - Neutrophils are the typical effector cells of the innate immune response because they are the first leukocytes to be recruited to an inflammatory site where they engulf invading microorganisms and destroy them by multiple oxidative and non-oxidative mechanisms. The destructive potential of neutrophils requires the tight control of their recruitment into tissue compartments and the production of inflammatory mediators such as reactive oxygen species. These oxidants can be highly toxic not only for infectious agents but also for neighbouring host tissues resulting in various autoimmune and inflammatory diseases. Thus, a significant attention in medicine is paid to approaches designed to modulate the metabolic activity of neutrophils. Synthetic steroid and non-steroid compounds with adverse side effects are commonly used for this purpose. The effects of natural substances which can modulate the metabolic activity of neutrophils and which simultaneously would not exert any significant unfavourable side effects have recently been investigated. Suitable candidates for this purpose might be compounds contained in herbs. These include especially polysaccharides and polyphenols, but also terpenes. The aim of the present paper is to summarize contemporary knowledge on the effects of compounds from herbs on the metabolic activity of mammalian neutrophils.
ER  -

LOJEK, Antonin; Petko DENEV; Milan CIZ; Ondřej VAŠÍČEK a Maria KRATCHANOVA. The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils. \textit{Phytochemistry Reviews}. Dordrecht: Springer, 2014, roč.~13, č.~2, s.~499-510. ISSN~1568-7767. Dostupné z: https://doi.org/10.1007/s11101-014-9340-x.

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